Bufexamac
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- CAS-Nr.
- 2438-72-4
- Bezeichnung:
- Bufexamac
- Englisch Name:
- Bufexamac
- Synonyma:
- j3;cp1044;feximac;mofenar;parfenac;droxaryl;droxarol;cp1044j3;flogicid;norfemac
- CBNumber:
- CB7768637
- Summenformel:
- C12H17NO3
- Molgewicht:
- 223.27
- MOL-Datei:
- 2438-72-4.mol
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Bufexamac Eigenschaften
- Schmelzpunkt:
- 153-155°
- Siedepunkt:
- 364.56°C (rough estimate)
- Dichte
- 1.1223 (rough estimate)
- Brechungsindex
- 1.5300 (estimate)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethyl acetate and in methanol.
- Aggregatzustand
- Solid
- pka
- 9.24±0.20(Predicted)
- Farbe
- White to Off-White
- Merck
- 14,1474
- CAS Datenbank
- 2438-72-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| RTECS-Nr. |
AK8280000 |
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| HS Code |
2928.00.2500 |
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| Toxizit?t |
LD50 orally in mice, rats: >8, >4 g/kg (Lambelin) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Bufexamac Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White Solid
Verwenden
Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing
Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids.
Definition
ChEBI: A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.
Weltgesundheitsorganisation (WHO)
Bufexamac, an analgesic and anti-inflammatory agent, was
introduced in 1974 for the topical treatment of a wide range of dermatoses. The
drug is widely marketed and the World Health Organization is not aware of
restrictive action having been taken elsewhere.
Kontakt-Allergie
Bufexamac is an arylacetic nonsteroidal anti-inflammatory
drug. It induces allergic contact dermatitis,
eczematous or erythema multiforme like type, and
even generalized eruptions like acute generalized
exanthematous pustulosis.
Bufexamac Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Bufexamac Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 280)Lieferanten
2438-72-4(Bufexamac)Verwandte Suche:
- 2-(p-butoxyphenyl)-acetohydroxamicaci
- 4-butoxy-n-hydroxy-benzeneacetamid
- 4-butoxy-n-hydroxybenzeneacetamide
- 4-butoxyphenylacetohydroxamicacid
- acidep-butoxyphenylacethydroxamique
- bufexamicacid
- cp1044
- cp1044j3
- droxarol
- droxaryl
- parfenac
- p-butoxyphenylacetohydroxamicacid
- AURORA KA-853
- BUFEXAMAC
- 2-(4-BUTOXYPHENYL)-N-HYDROXYACETAMIDE
- LABOTEST-BB LT00134645
- 2-(p-butoxyphenyl)acetohydroxamic acid
- 2-(4-butoxyphenyl)acetohydroxamic acid
- 4-Butoxyphenylacethydroxamic acid
- p-Butoxyphenylacethydroxamic acid
- 2-(p-Butoxyphenyl)acetohydoroximic acid
- 2-(4-butoxyphenyl)ethanehydroxamic acid
- 2-(4-butoxyphenyl)-N-hydroxy-ethanamide
- Bufexamac, >=98%
- feximac
- flogicid
- flogocidnplastigel
- j3
- malipuran
- mofenar
- norfemac
- Bufexamac, 98%, a COX inhibitor
- tantalum(2+)
- Bufexamac CRS
- Bufexamac >
- Benzeneacetamide, 4-butoxy-N-hydroxy-
- Bufexamac USP/EP/BP
- Bufexamac (Bufexamic acid)
- Bufexamac, ≥ 98.0%
- Bufexamac, 10 mM in DMSO
- Bufexamac 1.0 mg/ml in Acetonitrile
- Bufexamac (Standard)
- 2438-72-4
- C12H17NO3
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
- BI - BZ
- API
- NORFEMAC
- Chemistry
- Miscellaneous
- Lipid signaling
