Lofepramin
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- CAS-Nr.
- 23047-25-8
- Bezeichnung:
- Lofepramin
- Englisch Name:
- LOFEPRAMINE
- Synonyma:
- Amplit;Gamanil;Leo 640;Lopramine;LOFEPRAMINE;Lofepramine - Bio-X ?;Lofepramine in methanol;Lofepramine, 10 mM in DMSO;Inhibitor,inhibit,Lofepramine;4'-Chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl-methylamino]acetophenone
- CBNumber:
- CB7799244
- Summenformel:
- C26H27ClN2O
- Molgewicht:
- 418.96
- MOL-Datei:
- 23047-25-8.mol
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Lofepramin Eigenschaften
- Schmelzpunkt:
- 103-105°C
- Dampfdruck
- 0Pa at 25℃
- storage temp.
- Store at +4°C
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Light Yellow to Light Beige
- Wasserl?slichkeit
- 2.04mg/L at 25℃
- Stabilit?t:
- Unstable in Solution
Lofepramin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine. It potently inhibits serotonin and norepinephrine transporters (K
ds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.
Chemische Eigenschaften
Light Yellow Solid
Biologische Aktivit?t
Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo .
Mechanism of action
Lofepramine differs from imipramine by the attachment of a p-chlorophenacyl moiety to the N-aminopropyl
side chain. This change confers enhanced lipophilicity and the potential of more rapid
distribution into the CNS with greater in vitro affinity and selectivity for NET. Its mechanism of antidepressant
action is attributed to its rapid metabolism to the secondary amine metabolite, desipramine, which selectively
inhibits the neuronal uptake of NE.
Lofepramin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lofepramin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 61)Lieferanten
23047-25-8(Lofepramin)Verwandte Suche:
3-Dibenz(b,e)oxepin-11(6H)-yliden-N,N-dimethyl-1-propanamin-hydrochlorid
Clomipramin
5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid
10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin
10,11-Dihydro-N-methyl-5H-dibenz-(b,f)azepin-5-propanamin-mono-hydrochlorid
Lofepramin
1-(4-Chlorphenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethan-1-onmonohydrochlorid
- LOFEPRAMINE
- Gamanil
- 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethanone
- 4'-Chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl-methylamino]acetophenone
- Amplit
- Leo 640
- Lopramine
- 1-(4-Chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz(Z)[b,f]azepin-5-yl)propyl]methylamino]ethanone
- Ethanone, 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-
- 1-(4-Chlorophenyl)-2-((3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)(methyl)amino)ethan-1-one
- Inhibitor,inhibit,Lofepramine
- 2-[(3-{2-azatricyclo[9.4.0.03,?]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}propyl)(methyl)amino]-1-(4-chlorophenyl)ethan-1-one
- Lofepramine in methanol
- Lofepramine, 10 mM in DMSO
- Lofepramine - Bio-X ?
- 23047-25-8
- C26H27ClN2O
- C26H27N2OCl
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
