3-Amino-1,2,3,4-tetrahydrocarbazol
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- CAS-Nr.
- 61894-99-3
- Englisch Name:
- 3-Amino-1,2,3,4-tetrahydrocarbazol
- Synonyma:
- 273-Amino-tetrahydrocarbazole;3-amino-1,2,3,4-tetrahydrocarbazol;3-aMino-1,2,3,4-tetrahydrocarbazole;2,3,4,9-Tetrahydro-1H-carbazol-3-amine;1H-Carbazol-3-amine, 2,3,4,9-tetrahydro-;TIANFU-CHEM - 3-Amino-1,2,3,4-tetrahydrocarbazol
- CBNumber:
- CB81138348
- Summenformel:
- C12H14N2
- Molgewicht:
- 186.25
- MOL-Datei:
- 61894-99-3.mol
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3-Amino-1,2,3,4-tetrahydrocarbazol Eigenschaften
- Schmelzpunkt:
- 170-172 °C(Solv: ethanol (64-17-5))
- Siedepunkt:
- 362.5±42.0 °C(Predicted)
- Dichte
- 1.191±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 17.54±0.40(Predicted)
- Aussehen
- Off-white to light brown Solid
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
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P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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3-Amino-1,2,3,4-tetrahydrocarbazol Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 22, p. 191, 1985
DOI: 10.1002/jhet.5570220146
Synthese
3-Amino-1,2,3,4-tetrahydrocarbazol is prepared by the reaction of 1,4-dioxaspiro[4.5]decan-8-amine and phenylhydrazine. The specific synthesis steps are as follows:
General procedure: Aqueous sulfuric acid solution (10 % w/v, 30 mL) was taken in a round bottom flask, added (1,4-dioxa-spiro[4.5]dec-8-yl)dimethylamine (12a, 1.5 g, 8.1 mmol) followed by phenylhydrazine (1.52 g, 14.08 mmol) at room temperature. The reaction mass was heated to reflux temperature (95-100 °C) and maintained reflux for 2-3 h. The progress of the reaction was monitored by TLC. After completion of reaction, the reaction mass was cooled to 10-15 °C. Then the mass was basified with aqueous sodium hydroxide solution (20 % w/v) and the aqueous layer was extracted with ethyl acetate. Organic layer was washed with brine solution, dried over anhydrous sodium sulfate and organic volatiles were removed by distillation under vacuum. The crude compound was purified by flash chromatography (ethyl acetate: triethylamine 9:0.2) to obtain 0.8 g of 3-Amino-1,2,3,4-tetrahydrocarbazol (13a), the yield being 50 %.
3-Amino-1,2,3,4-tetrahydrocarbazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Amino-1,2,3,4-tetrahydrocarbazol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 67)Lieferanten
61894-99-3()Verwandte Suche:
- 3-amino-1,2,3,4-tetrahydrocarbazol
- 2,3,4,9-Tetrahydro-1H-carbazol-3-amine
- 3-aMino-1,2,3,4-tetrahydrocarbazole
- 1H-Carbazol-3-amine, 2,3,4,9-tetrahydro-
- TIANFU-CHEM - 3-Amino-1,2,3,4-tetrahydrocarbazol
- 273-Amino-tetrahydrocarbazole
- 61894-99-3
