(17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on
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- CAS-Nr.
- 54048-10-1
- Bezeichnung:
- (17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on
- Englisch Name:
- Etonogestrel
- Synonyma:
- Nexplanon;Implanon;desogestrel impurity D;org3236;CS-1364;Etonoestrel;ETONOGESTREL;3-oxodesogestrel;Etonogestrel CRS;3-KETO DESOGESTREL
- CBNumber:
- CB8146610
- Summenformel:
- C22H28O2
- Molgewicht:
- 324.46
- MOL-Datei:
- 54048-10-1.mol
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(17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on Eigenschaften
- Schmelzpunkt:
- 182-184°C
- Siedepunkt:
- 473.1±45.0 °C(Predicted)
- alpha
- D +87.6°
- Dichte
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: >5mg/mL
- pka
- 13.04±0.40(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Rotation
- [α]/D +80 to +95°, c = 1 (CHCl3)
- InChI
- InChI=1/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/s3
- InChIKey
- GCKFUYQCUCGESZ-BPIQYHPVSA-N
- SMILES
- C([C@]12CC(=C)[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,5,7,17,19,23,r|
- CAS Datenbank
- 54048-10-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| R-S?tze: |
60-40 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
JF8290000 |
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| HS Code |
2937230000 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Carc. 2
Repr. 1B |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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(17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.
Chemische Eigenschaften
White Solid
Verwenden
A biologically active metabolite of Desogestrel.
Definition
ChEBI: Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug.
Allgemeine Beschreibung
Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing).
Mode of action
Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
(17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 231)Lieferanten
54048-10-1((17α)-13-Ethyl-17-hydroxy-11-methylen-18,19-dinorpregn-4-en-20-yn-3-on)Verwandte Suche:
- Desogestrel Related CoMpound C
- 13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one
- 3-KETO DESOGESTREL
- ETONOGESTREL
- (17alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
- 3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon
- (17R)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
- Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel)
- Etonoestrel
- (17α)-13-Ethyl-17-hydroxy-11-Methylene-18,19-dinorpregn-4-en-20-yn-3-one
- (17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
- (17-alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-on
- 13-ethyl-11-methylene-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
- 17-ethinyl-17-beta-hydroxy-18-methyl-11-methylene-4-estren-3-one
- 19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-1(17-alpha
- 3-oxodesogestrel
- org3236
- Deoxypregnancy impurity D
- Etonogestrel-d6（Desogestrel EP Impurity D-d6）
- Desogestrel EP Impurity D-d6
- IMPLANON;NEXPLANON;3-OXODESOGESTREL;3-KETO-DESOGESTREL
- CS-1364
- Desogestrel Impurity 4(Desogestrel EP Impurity D)
- 3-Ketodesogestrel (Etonogestrel)
- Etonogestrel Solution
- Deoxyprene impurity D
- 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-
- Etonogestrel USP/EP/BP
- ETONOGESTREL 54048-10-1
- EtonogestrelQ: What is
Etonogestrel Q: What is the CAS Number of
Etonogestrel Q: What is the storage condition of
Etonogestrel Q: What are the applications of
Etonogestrel
- Etonogestrel D6Q: What is
Etonogestrel D6 Q: What is the CAS Number of
Etonogestrel D6 Q: What is the storage condition of
Etonogestrel D6
- Etonogestrel D7Q: What is
Etonogestrel D7 Q: What is the CAS Number of
Etonogestrel D7 Q: What is the storage condition of
Etonogestrel D7
- Desogestrel Related Compound C (3-Ketodesogestrel) (1173268)
- Etonogestrel (1268783)
- 11-Dihydrocarbamazepine
- Implanon
- Desogestrel USP Related Compound C
- Desogestrel Related Compound C (3-Ketodesogestrel)
- Etonogestrel (Desogestrel EP Impurity D, Desogestrel USP Related Compound C, 3-Ketodesogestrel)
- Desogestrel Related Compound C (25 mg) (13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol-3-one)
- 13-Ethyl-17-hydroxy-11-methylidene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one (3-Ketodesogestrel)
- Etonogestrel, 10 mM in DMSO
- Etonogestrel CRS
- 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-
- desogestrel impurity D
- Nexplanon
- 54048-10-1
- 54058-10-1
- C22H28O2
- Various Metabolites and Impurities
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Steroids
- API
- Inhibitors
- Hormone Drugs
