Desogestrel
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- CAS-Nr.
- 54024-22-5
- Bezeichnung:
- Desogestrel
- Englisch Name:
- Desogestrel
- Synonyma:
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL
- CBNumber:
- CB2359630
- Summenformel:
- C22H30O
- Molgewicht:
- 310.47
- MOL-Datei:
- 54024-22-5.mol
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Desogestrel Eigenschaften
- Schmelzpunkt:
- 109-110°C
- alpha
- D20 +55° (chloroform)
- Siedepunkt:
- 390.62°C (rough estimate)
- Dichte
- 1.0169 (rough estimate)
- Brechungsindex
- 1.5100 (estimate)
- storage temp.
- -20°C Freezer
- L?slichkeit
- Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
- Aggregatzustand
- Solid
- pka
- 13.07±0.40(Predicted)
- Farbe
- White to Almost white
- Merck
- 14,2926
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3
- InChIKey
- RPLCPCMSCLEKRS-UHFFFAOYSA-N
- SMILES
- C1C2C(CCC3C2C(=C)CC2(CC)C3CCC2(C#C)O)=CCC1
Desogestrel Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity,
ex vivo in human lymphocytes and CD8
+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
Chemische Eigenschaften
White Solid
Verwenden
A progestogen with low androgenic potency
Allgemeine Beschreibung
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
Clinical Use
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
Desogestrel Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Desogestrel Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 354)Lieferanten
54024-22-5(Desogestrel)Verwandte Suche:
- (17α)-13-Ethyl-11-methylene-18，19-dinorpregn-4-en-20-yn-17-ol
- (8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- (17R)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
- (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- Desogestrel (50 mg)
- DESTODENE
- Desogestrel for system suitability, European Pharmacopoeia (EP) Reference Standard
- Desogestrel, >=99%
- (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-Methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
- 13-ethyl-11-methylene-19-dinorpregn-4-en-20-yn-17-o(17-alpha)-1
- org2969
- 13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
- DESOGESTREL
- (17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
- Cerazette
- Cyclosa
- Dicromil
- Marvelon 150/320
- 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17.alpha.)-
- (17β)-13-Ethyl-11-methylene-19-nor-pregn-4-en-20-yn-17-ol
- DESOGESTRAL
- 13-Ethyl-11-methylene-18,19-dinor-17α-4-pregnen-20-yn-17-ol
- Desogestrel, 99%, a third-generation 19-nortestosterone derivative progestogen
- Desogestrel Solution
- Desogestrel>
- Desogestrelum
- 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17α)-
- Desogestrel USP/EP/BP
- DesogestrelQ: What is
Desogestrel Q: What is the CAS Number of
Desogestrel Q: What is the storage condition of
Desogestrel Q: What are the applications of
Desogestrel
- Desogestrel (1173235)
- Desogestrel for system suitability CRS
- Desogestrel CRS
- Desogen
- Desogestrol
- Desogestrel Solution in Methanol
- Desogestre!
- Desogestrel, 10 mM in DMSO
- 13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
- 54024-22-5
- C22H30O
- Hormone Drugs
- Steroid and Hormone
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- API
