Lynestrenol
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- CAS-Nr.
- 52-76-6
- Bezeichnung:
- Lynestrenol
- Englisch Name:
- Lynestrenol
- Synonyma:
- 17-alpha-ethinyl-17-beta-hydroxyoestr-4-ene;exluten;exluton;lynenol;LYNDIOL;exlution;exlutona;Exlutena;nsc-37725;org485-50
- CBNumber:
- CB2441014
- Summenformel:
- C20H28O
- Molgewicht:
- 284.44
- MOL-Datei:
- 52-76-6.mol
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Lynestrenol Eigenschaften
- Schmelzpunkt:
- 158°C
- alpha
- D -13° (chloroform)
- Siedepunkt:
- 366.92°C (rough estimate)
- Dichte
- 1.0083 (rough estimate)
- Brechungsindex
- 1.4500 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Practically insoluble in water, soluble in acetone and in ethanol (96 per cent).
- pka
- 13.12±0.40(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Crystals from MeOH
- Merck
- 14,5629
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C20H28O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h1,6,15-18,21H,4-5,7-13H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1
- InChIKey
- YNVGQYHLRCDXFQ-XGXHKTLJSA-N
- SMILES
- O[C@@]1([C@@]2([C@H]([C@H]3[C@@H]([C@H]4CCCC=C4CC3)CC2)CC1)C)C#C
- CAS Datenbank
- 52-76-6
- EPA chemische Informationen
- Lynestrenol (52-76-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Lynestrenol Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.
Weltgesundheitsorganisation (WHO)
Lynestrenol, a synthetic progestogen, was introduced in the early
1960s as a component in oral contraceptive preparations. In 1967, as a result of
new regulations required by the United States Food and Drug Administration,
lynestrenol was submitted to long-term toxicity studies and by the early 1970s it
was shown to be associated with an increased incidence of mammary tumours in
beagle bitches which led to its withdrawal by at least one regulatory authority.
Subsequently the validity of the beagle bitch model as a predictor of
carcinogenicity of steroid contraceptives has been contested by many national
regulatory authorities and lynestrenol remains available in some countries for
contraceptive and other purposes.
(Reference: (WHODI) WHO Drug Information, 1-3, 5-7, 1984)
Sicherheitsprofil
An experimental teratogen.Experimental reproductive effects. Human reproductiveeffects by ingestion and implant routes: menstrual cyclechanges or disorders, female fertility index, other fertilitychanges and effects on females. Questionable carcinoge
Lynestrenol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lynestrenol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 233)Lieferanten
52-76-6(Lynestrenol)Verwandte Suche:
- 4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL
- 4-ESTREN-17A-ETHINYL-17BETA-OL
- 19-nor-17-alpha-pregn-4-en-20-yn-17-l
- ETHINYLESTRENOL
- LYNOESTRENOL
- LYNESTRENOL
- (17-alpha)-19-norpregn-4-en-20-yn-17-ol
- 17-alpha-ethinyl-17-beta-hydroxyestr-4-ene
- 17-alpha-ethynil-delta-4-estrene-17-beta-ol
- 17-alpha-ethynylestr-4-en-17-beta-ol
- 17-alpha-ethynylestrenol
- 17-alpha-ethynyloestr-4-en-17-beta-ol
- 17-alpha-ethynyloestrenol
- 19-nor-17-alpha-pregn-4-en-20-yn-17-ol
- 3-desoxynorlutin
- delta(sup4)-17-alpha-ethinylestren-17-beta-ol
- delta(sup4)-17-alpha-ethinyloestren-17-beta-ol
- ethinyloestranol
- ethinyloestrenol
- ethynloestrenol
- ethynylestrenol
- exluten
- exlution
- exluton
- exlutona
- linestrenol
- lynenol
- nsc-37725
- org485-50
- orgametil
- orgametril
- 19-nor-17-alpha-pregn-4-en-20-yn-17-beta-ol
- LYSINE HCL FEED GRADE
- LYNESTRENOL(SH)
- LYNDIOL
- Exlutena
- LYNESTRENOL(RG)
- Lynestrenol (20 mg)
- 19-Nor-4-pregnen-20-yn-17beta-ol
- (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-Methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
- (17α)-19-Norpregn-4-en-20-yn-17-ol
- Lynestrenol for peak identification CRS
- Lynestrenol CRS
- 19-Norpregn-4-en-20-yn-17-ol, (17α)-
- LYNESTRENO
- Lynestrenol (1370906)
- (8R,9S,10R,13S,14S,17S)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
- Reagent raw materials
- 4-ESTREN-17α-ETHYNYL-17β-OL
- Lynestrenol (20 mg) ((17alpha) -19-Norpregn-4-en-20-yn-17-ol)
- Lynestrenol
CAS
- Linestone
- lynestrenol impurity
- 17-alpha-ethinyl-17-beta-hydroxyoestr-4-ene
- 52-76-6
- Steroids
- Hormone
- Intracellular receptor
