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Tocainid

TOCAINIDE Struktur
41708-72-9
CAS-Nr.
41708-72-9
Bezeichnung:
Tocainid
Englisch Name:
TOCAINIDE
Synonyma:
W-36095;TOCAINIDE;Astra W-36095;TOCAINIDE USP/EP/BP;alanyl-2,6-xylidide;Tocainide, 10 mM in DMSO;Naphthoic Acid Impurity 26;6'-propionoxylidide, 2-amino-2;2-amino-2',6'-propionoxylidide;N-(2-Aminopropionyl)-2,6-xylidine
CBNumber:
CB8210193
Summenformel:
C11H16N2O
Molgewicht:
192.26
MOL-Datei:
41708-72-9.mol

Tocainid Eigenschaften

Schmelzpunkt:
246-266 °C
Siedepunkt:
328.25°C (rough estimate)
Dichte
1.0529 (rough estimate)
Brechungsindex
1.5750 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
DMSO: Soluble: =10 mg/ml
Ethanol: Slightly Soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
Aggregatzustand
Solid
pka
pKa 7.75(H2O t = 25.0±0.2 I = 0.01 (NaCl)) (Uncertain)
Farbe
White to off-white
CAS Datenbank
41708-72-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Tocainid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

Verwenden

Tocainide is used for suppressing symptoms of ventricular arrhythmia and tachycardia, and for premature cardiac contractions.

Definition

ChEBI: A monocarboxylic acid amide in which 2,6-dimethylphenylaniline and isobutyric acid have combined to form the amide bond; used as a local anaesthetic.

Weltgesundheitsorganisation (WHO)

Tocainide, an antidysrhythmic agent, was introduced in 1981 for the treatment of ventricular dysrhythmias. By 1984 its use was associated with cases of agranulocytosis, aplastic anaemia and thrombocytopenia, some of which were fatal. This led some regulatory authorities to restrict the indications for its use. The major manufacturer has subsequently restricted its use on a worldwide basis to the treatment of symptomatic ventricular dysrhythmias not responding to other therapy, or when other therapy is contraindicated.

Pharmakokinetik

The α-methyl group is believed to slow the rate of metabolism and, thereby, to contribute to oral activity. The plasma half-life of tocainide is approximately 12 hours, and nearly 50% of the drug may be excreted unchanged in the urine. Adverse effects associated with tocainide are like those observed with lidocaine—specifically, gastrointestinal disturbances and central nervous system effects.

Clinical Use

Tocainide (Tonocard) is an orally effective antiarrhythmic agent with close structural similarities to lidocaine. Tocainide is indicated for the treatment of symptomatic ventricular arrhythmias refractory to more conventional therapy. Serious noncardiac adverse effects limit its use to patients with life-threatening arrhythmias.

Nebenwirkungen

Light-headedness, dizziness, or nausea occurs in approximately 15% of patients, paresthesias and numbness in 9%, and tremor in 8%.These adverse effects are generally mild in intensity, transient, and dose related. Overall, however, approximately 20% of patients prescribed tocainide discontinue therapy because of such effects. Serious immune-based side effects, such as pulmonary fibrosis, have been reported, and blood dyscrasias, such as agranulocytosis and thrombocytopenia, may occur in up to 0.2% of patients.

Arzneimittelwechselwirkung

When used with other class IB antiarrhythmic drugs, tocainide toxicity may be increased without significant gain in antiarrhythmic efficacy.

Vorsichtsma?nahmen

Patients who are hypersensitive to tocainide or to local anesthetics of the amide type should not be exposed to tocainide.The presence of second- or third-degree heart block in the absence of an artificial pacemaker also contraindicates the use of tocainide.

Tocainid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tocainid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 66)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32467 58
Wuxi Rejoys chemical Technology Co., Ltd.
0510-86103381
sales@rejoyschem.com CHINA 976 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9996 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39040 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8615965530500
nickzhang@hangyubiotech.com China 9946 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+86-18621343501; +undefined18621343501
product@acmec-e.com China 33324 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55

41708-72-9(Tocainid)Verwandte Suche:


  • TOCAINIDE
  • 2-amino-2',6'-propionoxylidide
  • 2-amino-n-(2,6-dimethylphenyl)-propanamid
  • 6'-propionoxylidide, 2-amino-2
  • alanyl-2,6-xylidide
  • Astra W-36095
  • W-36095
  • 2-Amino-N-(2,6-dimethylphenyl)propanamide
  • N-(2-Aminopropionyl)-2,6-xylidine
  • N1-(2,6-dimethylphenyl)alaninamide
  • TOCAINIDE USP/EP/BP
  • Sodium Channel,Na+ channels,Tocainide,tinnitus,lidocaine,Na channels,Inhibitor,inhibit
  • Naphthoic Acid Impurity 26
  • Tocainide, 10 mM in DMSO
  • 41708-72-9
  • Cell Signaling and Neuroscience
  • Sodium Channel Modulators
  • Voltage-gated Ion Channels
  • Other Sodium Channel Modulators
  • Ion Channels
  • Monovalent Ion Channels
  • BioChemical
  • Cell Biology
  • Active Pharmaceutical Ingredients
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