一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

DMOG

DMOG Struktur
89464-63-1
CAS-Nr.
89464-63-1
Englisch Name:
DMOG
Synonyma:
DIMETHYLOXALYLGLYCINE;OMOG;Dimethyloxaloylglycine;DIMETHYLOXALLYL GLYCINE;OMO;DMOG;DMOG, >=98%;DMOG USP/EP/BP;Dimethyloxalylglycine (Dmog);DMOG (dimethyloxaloylglycine)
CBNumber:
CB8223849
Summenformel:
C6H9NO5
Molgewicht:
175.14
MOL-Datei:
89464-63-1.mol

DMOG Eigenschaften

Schmelzpunkt:
46-48°C
Siedepunkt:
179-182 °C(Press: 12 Torr)
Dichte
1.246±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
H2O: >30mg/mL
pka
10.55±0.46(Predicted)
Aggregatzustand
Solid
Farbe
white to off-white
Wasserl?slichkeit
Soluble in water at 30mg/ml.
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions are not stable. Solutions must be made fresh and used within 1 working day.
InChI
InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
InChIKey
BNJOZDZCRHCODO-UHFFFAOYSA-N
SMILES
C(OC)(=O)CNC(C(OC)=O)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 22
WGK Germany  3
HS Code  2924.19.8000
HazardClass  IRRITANT
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

DMOG Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.

Chemische Eigenschaften

Off-White to Pale Pink Solid

Verwenden

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models (1nM). DMOG also inhibits FIH (factor inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/Kg).

Enzyminhibitor

This iron-binding a-ketoglutarate (2-oxoglutarate) analogue (FW = 147.09 g/mol; also named N-oxaloglycine) competitively inhibits prolyl-4- hydroxylase (Reaction: Procollagen (L-proline) + a-ketoglutarate + O2 → Procollagen ( (2S,4R) -4-hydroxyproline) + succinate + CO2). During catalysis, prolyl-4-hydroxylase forms Fe (III), and the latter most likely makes an extremely stable metal ion complex with N-oxaloglycine. Substitution on the glycine moiety alters inhibitor activity stereoselectively and that, if the w-carboxylate is homologated or replaced, either by acylsulfonamides or anilide, activity is likewise sharply reduced. Prolyl- 4-Hydroxylase Catalysis: Each catalytic round of this posttranslational modifying enzyme reaction occurs in two stages. O2 is bound end-on in an axial position, producing a dioxygen unit. Nucleophilic attack at C-2 generates a tetrahedral intermediate, with loss of the double bond in dioxygen and bonds to iron and the a-carbon of a-ketoglutarate. Elimination of CO2 coincides with formation of the Fe (IV) =O species. The second stage involves the abstraction of the pro-R hydrogen atom from C-4 of proline, followed by radical combination, yielding hydroxyproline. In the presence of a-ketoglutarate, enzyme-bound Fe2+ is rapidly converted to Fe3+, resulting in inactivation of the enzyme Ascorbate is utilized as a cofactor to reduce Fe (III) back to Fe (II). Cell-Permeable Analogue: Dimethyloxalylglycine (FW = 175.14 g/mol; CAS 89464-63-1; Symbol: DMOG, also named N- (methoxyoxoacetyl) -glycine methyl ester) is metabolicaly demethylated to form N-oxaloglycine upon entry to many cells.

DMOG Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DMOG Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 209)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5745 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32467 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 28509 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896
cbc@coresyn.com China 9984 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11680 58

89464-63-1()Verwandte Suche:


  • N-(METHOXYOXOACETYL)-GLYCINE METHYL ESTER
  • N-[(Methoxycarbonyl)Methyl]oxaMic Acid Methyl Ester
  • DiMethyloxaloylglycine (DMOG)
  • METHYL 2-(2-METHOXY-2-OXOETHYLAMINO)-2-OXOACETATE
  • N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
  • DMOG Dimethyloxalylglycine N-[(Methoxycarbonyl)methyl]oxamic acid methyl ester
  • DMOG, >=98%
  • HIF-Hydroxylase Inhibitor, DMOG
  • Glycine,N-(2-methoxy-2-oxoacetyl)-, methyl ester
  • DMOG
  • DMOG (dimethyloxaloylglycine)
  • DMOG USP/EP/BP
  • methyl 2-(2-methoxy-2-oxoacetamido)acetate
  • Dimethyloxalylglycine (Dmog)
  • methyl n-[methoxy(oxo)acetyl]glycinate
  • DMOG; DIMETHYLOXALLYL GLYCINE; DIMETHYLOXALYLGLYCINE; 89464-63-1; METHYL N-[METHOXY(OXO)ACETYL]GLYCINATE
  • HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem
  • Dimethyloxaloylglycine
  • OMOG
  • Dimethyloxalylglycine|||Dimethyloxallyl Glycine|||Dimethyloxaloylglycine
  • OMO
  • Dimethyloxaloylglycine, Prolyl hydroxylase (PHD) inhibitor
  • DIMETHYLOXALLYL GLYCINE
  • DIMETHYLOXALYLGLYCINE
  • 89464-63-1
  • Other
  • Bio-material
  • NONE
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives
  • Inhibitors
Copyright 2019 ? ChemicalBook. All rights reserved
锦州市| 郧西县| 瓦房店市| 武功县| 湘乡市| 柞水县| 宜川县| 天全县| 崇义县| 蒙城县| 铜梁县| 鄂托克旗| 宜良县| 亳州市| 孟津县| 南宁市| 禄丰县| 顺平县| 南宫市| 庄河市| 兰坪| 寿阳县| 绥德县| 新津县| 新蔡县| 松江区| 安国市| 万盛区| 瑞丽市| 天门市| 林口县| 仲巴县| 桂阳县| 昌图县| 拉萨市| 翼城县| 新蔡县| 云龙县| 山东| 江都市| 黄梅县|