Amfonelic acid
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- CAS-Nr.
- 15180-02-6
- Englisch Name:
- Amfonelic acid
- Synonyma:
- NCA;Amfonelic;7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;CEAL;WIN-25978;NSC-100638;Amphonic acid;AMFONELIC ACID;AMFONELIC ACID INCREASES DOPAMINE RE;Amfonelic Acid/ CAS NO.15180-02-6/99%
- CBNumber:
- CB8315692
- Summenformel:
- C18H16N2O3
- Molgewicht:
- 308.33
- MOL-Datei:
- 15180-02-6.mol
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Amfonelic acid Eigenschaften
- Schmelzpunkt:
- >1000 °C
- Siedepunkt:
- 499℃
- Dichte
- 1.297
- Flammpunkt:
- 256℃
- L?slichkeit
- 0.1 M NaOH: soluble
- Aggregatzustand
- powder
- pka
- 3.50±0.20(Predicted)
- Farbe
- yellow
- InChI
- InChI=1S/C18H16N2O3/c1-2-20-11-15(18(22)23)16(21)14-9-8-13(19-17(14)20)10-12-6-4-3-5-7-12/h3-9,11H,2,10H2,1H3,(H,22,23)
- InChIKey
- WHHHJDGNBVQNAU-UHFFFAOYSA-N
- SMILES
- N1(CC)C2C(=CC=C(CC3=CC=CC=C3)N=2)C(=O)C(C(O)=O)=C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
40-43 |
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| S-S?tze: |
36/37 |
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| WGK Germany |
3 |
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| HS Code |
2933.99.8290 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Amfonelic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Amfonelic acid, a derivative of nalidixic acid, was originally developed as a central nervous system stimulant. It is a highly potent nonamphetamine stimulant whose actions are inhibited by reserpine but not by the tyrosine hydroxylase inhibitor, a-methyltyrosine. Additionally, it enhances the impacts of antipsychotic medicines such as haloperidol, trifluoperazine, and spiperone.
Verwenden
Amfonelic acid (AFA) is a dopamine reuptake inhibitor, that has marked effects on brain dopamine metabolism but not noradrenaline metabolism. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically. Rats are shown to self-administer amfonelic acid in a dose-dependent manner.
Einzelnachweise
The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward DOI:
10.1016/0091-3057(89)90069-5
Pharmacologic properties and mechanism of action of amfonelic acid DOI:
10.1016/0014-2999(70)90206-2
Einzelnachweise
[1] P C Waldmeier. “The effects of amfonelic acid on 5-HT metabolism in rat brain.” Journal of Neural Transmission 57 3 (1983): 149–65.
Amfonelic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amfonelic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 93)Lieferanten
15180-02-6()Verwandte Suche:
- AMFONELIC ACID
- 1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-4-oxo-7-(phenylMethyl)-
- 1-Ethyl-1,4-dihydro-4-oxo-7-(phenylmethyl)-1,8-naphthyridine-3-carboxylic acid
- AMFONELIC ACID INCREASES DOPAMINE RE
- amfonelic acid (7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid)
- 7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
- NSC-100638
- WIN-25978
- 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
- Hot Selling Amfonelic Acid Powder?15180-02-6?with Best Price From Wujiaren Lab
- 7-benzyl-1-ethyl-4-oxo-1,8-naphthyridine-3-carboxylicaci
- Amfonelic Acid/ CAS NO.15180-02-6/99%
- Amphonic acid
- CEAL
- 7-Benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- Amfonelic
- NCA
- 15180-02-6
