3,5,7-Trihydroxy-2-phenyl-4-benzopyron
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- CAS-Nr.
- 548-83-4
- Bezeichnung:
- 3,5,7-Trihydroxy-2-phenyl-4-benzopyron
- Englisch Name:
- Galangin
- Synonyma:
- 3,5,7-TRIHYDROXYFLAVONE;Galengin;GALANGIN;Galangin-RM;NORIZALPININ;Galangin 99%;GALANGIN hplc;Galangin (6CI);Galangin, >=98%;Galangin[282200]
- CBNumber:
- CB8413460
- Summenformel:
- C15H10O5
- Molgewicht:
- 270.24
- MOL-Datei:
- 548-83-4.mol
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3,5,7-Trihydroxy-2-phenyl-4-benzopyron Eigenschaften
- Schmelzpunkt:
- 214-215 °C(lit.)
- Siedepunkt:
- 333.35°C (rough estimate)
- Dichte
- 1.2319 (rough estimate)
- Brechungsindex
- 1.6000 (estimate)
- storage temp.
- room temp
- L?slichkeit
- Acetone (Slightly), Ethyl Acetate (Slightly)
- Aggregatzustand
- Solid
- pka
- 6.32±0.40(Predicted)
- Farbe
- Light Yellow to Yellow
- Merck
- 14,4339
- BRN
- 272179
- Major Application
- food and beverages
- Kosmetik-Inhaltsstoffe Funktionen
- SKIN PROTECTING
- InChI
- InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
- InChIKey
- VCCRNZQBSJXYJD-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)OC2=CC(O)=CC(O)=C2C(=O)C=1O
- LogP
- 3.322 (est)
- CAS Datenbank
- 548-83-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-37/39 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
LK9275500 |
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| F |
10 |
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| HS Code |
29329990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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3,5,7-Trihydroxy-2-phenyl-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties. It also has anti-inflammatory actions related to suppression of signaling through NF-κB in mice. Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells. It also inhibits cytochrome P450 isoform 1A1 with an IC
50 value of less than 1 μM.
Chemische Eigenschaften
Yellow powder
Definition
ChEBI: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively.
Allgemeine Beschreibung
Galangin is a flavonoid isolated from members of the
Zingiberaceae family, which are mainly used for herbal medicines.
Anticancer Research
Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).
3,5,7-Trihydroxy-2-phenyl-4-benzopyron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3,5,7-Trihydroxy-2-phenyl-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 412)Lieferanten
548-83-4(3,5,7-Trihydroxy-2-phenyl-4-benzopyron)Verwandte Suche:
7-Hydroxy-2-phenyl-4-benzopyron
Flavon
5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-on
Phenylvalerat
Isoflavone
ISOFLAVONES
3,3',4',5-Tetrahydroxy-7-methoxyflavon
Quercitrin
3-[(6-Desoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-benzopyran-4-on
3,3',4,4',5',7-Hexahydro-2-phenyl-4H-chromen-4-on
2',3,4',5,7-Pentahydroxyflavon
3,5,7-Trihydroxy-2-(2-hydroxyphenyl)-4-benzopyron
3-[[6-O-(6-Desoxy-α-L-mannopyranosyl)-β-D-galaktopyranosyl]oxy]-7-[(6-desoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-on
Phenylessigsure
Rutosid
3,4',5,7-Tetrahydroxyflavon
3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyron
Quercetin
- 4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-phenyl
- Galengin
- 3,5,7-Trihydroxy-2-phenyl-4h-benzopyran-4-one
- 3,5,7-Trihydroxy-2-phenyl-4H-chroMen-4-one
- Galangin, froM Alpinia officinaruM
- Galangin, >=98%
- GALANGIN, AUTOPHAGY INDUCING FLAVONO
- 3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
- 3,5,7-trihydroxy-flavon
- NORIZALPININ
- GALANGIN
- 3,5,7-trihydroxy-2-phenyl-chromen-4-one
- 3,5,7-Trihydroxyflavone (Galangin)
- 3,5,7-Trihydroxyflavone,97%
- GALANGIN hplc
- GALANGIN WITH HPLC
- 2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
- 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
- 3,5,7-trihydroxy-2-phenyl-4-benzopyrone
- Galangin Standard
- Galangin, 98%, from Alpinia officinarum
- 7-Trihydroxyflavone
- 3,5,7-trihydroxy-2-phenyl-1-benzopyran-4-one
- Galangin (6CI)
- Galangin-RM
- Galangin, 10 mM in DMSO
- Galangin 99%
- Galangin[282200]
- Alpinia officinarum Hance extract
- 3,5,7-TRIHYDROXYFLAVONE
- 548-83-4
- Antineoplastic
- Flavanols
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
