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Goralatide

Goralatide Struktur
127103-11-1
CAS-Nr.
127103-11-1
Englisch Name:
Goralatide
Synonyma:
AC-SDKP;SERASPENIDE;Thymosin β4 (1-4);Acetyl-SDKP;AC-SER-ASP-LYS-PRO;AC-SER-ASP-LYS-PRO-OH;GORALATIDE;AC-SDKP-DELTA;Thymosin beta4 (1-4);AC-SER-ASP-LYS-PRO-O
CBNumber:
CB8704926
Summenformel:
C20H33N5O9
Molgewicht:
487.5
MOL-Datei:
127103-11-1.mol

Goralatide Eigenschaften

Siedepunkt:
992.0±65.0 °C(predicted)
Dichte
1.382±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp. 
−20°C
L?slichkeit
Soluble in DMSO
pka
3.39±0.20(predicted)
Aggregatzustand
Solid
Farbe
White to off-white
Wasserl?slichkeit
Soluble in water at 2mg/ml
Sequenz
H-Gln-Lys-Leu-Val-Phe-Phe-Ala-OH

Sicherheit

WGK Germany  3

Goralatide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

N-Acetyl-Ser-Asp-Lys-Pro inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.

Synthese

Fmoc-Pro-OH was coupled to a 2-chlorotriphenylmethyl chloride resin, followed by sequential addition of Lys, Asp, and Ser units via cyclic deprotection (using piperidine/DMF) and coupling (using activating reagents such as TBTU/HOBt). After peptide chain elongation, the N-terminus was acetylated with acetic anhydride. Finally, the peptide was cleaved from the resin using a trifluoroacetic acid (TFA) cleavage reagent, simultaneously removing the side-chain protecting groups. High-purity Goralatide was obtained by ether precipitation and HPLC purification.

Goralatide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Goralatide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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127103-11-1()Verwandte Suche:


  • ACETYL-SER-ASP-LYS-PRO
  • AC-SDKP-DELTA
  • AcSDKP Ac-Ser-Asp-Lys-Pro
  • REF DUPL: Ac-Ser-Asp-Lys-Pro-OH
  • AcSDKP, SteM Cell Proliferation Inhibitor, Goralatide, ThyMosin b4 (1-4)
  • Ac-L-Ser-L-Asp-L-Lys-L-Pro-OH
  • N-Acetyl-Ser-Asp-Lys-Pro-OH
  • N-Ac-Ser-Asp-Lys-Pro-OH
  • Acetyl-serinyl-aspartyl-lysinyl-proline
  • GORALATIDE
  • L-Proline, N-acetyl-L-seryl-D-α-aspartyl-L-lysyl-
  • AC-SER-ASP-LYS-PRO-OH USP/EP/BP
  • 1-[2-[[2-[(2-acetamido-3-hydroxypropanoyl)amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid
  • Ac-Ser-Asp-Lys-Pro-OH (H-1156.0005)
  • Ac-SDKP,NAcetylSerAspLysPro,Inhibitor,inhibit,N Acetyl Ser Asp Lys Pro,Angiotensin-converting Enzyme (ACE)
  • Thymosin beta4 (1-4)
  • AC-SER-ASP-LYS-PRO-O
  • N-Acetyl-L-seryl-D-α-aspartyl-L-lysyl-L-proline
  • AC-SER-ASP-LYS-PRO-OH
  • AC-SER-ASP-LYS-PRO
  • Acetyl-SDKP
  • AC-SDKP
  • SERASPENIDE
  • Thymosin β4 (1-4)
  • 127103-11-1
  • C20H33N5O9
  • Peptides
  • BioChemical
  • Angiotensins
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Peptide
  • Angiotensins
  • Peptides for Cell Biology
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