ARG-GLY-ASP-SER
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- CAS-Nr.
- 91037-65-9
- Englisch Name:
- ARG-GLY-ASP-SER
- Synonyma:
- RGDS;RGDS - 5 mg;RGDS peptide;ARG-GLY-ASP-SER;RGDS 1/2ACOH 2H2O;L-ARG-GLY-ASP-SER;Arg-Gly-Asp-Ser-OH;H-ARG-GLY-ASP-SER-OH;RGDS/ARG-GLY-ASP-SER;FIBRONECTIN INHIBITOR
- CBNumber:
- CB9117206
- Summenformel:
- C15H27N7O8
- Molgewicht:
- 433.42
- MOL-Datei:
- 91037-65-9.mol
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ARG-GLY-ASP-SER Eigenschaften
- Schmelzpunkt:
- 183-187℃
- Dichte
- 1.65±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- ≥21.65 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
- pka
- 2.84±0.10(Predicted)
- Aggregatzustand
- White to off-white powder
- Farbe
- White to off-white
- Biologische Quelle
- synthetic
- Wasserl?slichkeit
- Soluble in water at 1mg/ml
- Sequenz
- H-Arg-Gly-Asp-Ser-OH
- InChIKey
- NNRFRJQMBSBXGO-CIUDSAMLSA-N
- SMILES
- N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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ARG-GLY-ASP-SER Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Arg-Gly-Asp-Ser has been used:
- to study its effects on cell attachment in rats
- to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
- to pretreat the cells, to assess the role of integrin in the cell attachment process
- to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)
Allgemeine Beschreibung
The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on
E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.
RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor 1 (TGF1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of
Mycobacterium tuberculosis to murine alveolar macrophages
ARG-GLY-ASP-SER Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ARG-GLY-ASP-SER Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 190)Lieferanten
- Fibronectin tetrapeptide
- L-Arginylglycyl-L-alpha-aspartyl-L-serine
- L-Serine, L-arginylglycyl-L-alpha-aspartyl-
- L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-
- arginyl-glycyl-aspartyl-serine
- RGDS 1/2ACOH 2H2O
- L-Serine,N-[N-(N-L-arginylglycyl)-L-a-aspartyl]-
- L-Serine,L-arginylglycyl-L-a-aspartyl-
- Arg-Gly-Asp-Ser, >=98%
- RGDS PEPTIDE;FIBRONECTIN INHIBITOR
- L-ARG-GLY-ASP-SER
- H-ARG-GLY-ASP-SER-OH
- FIBRONECTIN ATTACHMENT PEPTIDE
- ARG-GLY-ASP-SER
- ARG-GLY-ASP-SER 1/2ACOH 2H2O
- RGDS/ARG-GLY-ASP-SER
- Arg-Gly-Asp-Ser-OH
- L-Arg-Gly-L-Asp-L-Ser-OH
- RGDS peptide
- FIBRONECTIN INHIBITOR
- H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem
- Arg-Gly-Asp-Ser, ≥95%(HPLC)
- L-Serine, L-arginylglycyl-L-α-aspartyl-
- RGDS - 5 mg
- The integrin-blocking peptide
- RGDS peptide (Arg-Gly-Asp-Ser)
- RGDS
- 91037-65-9
- C15H27N7O8
- Extracellular Matrix Peptides and Proteins
- Extracellular Matrix
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Cytoskeleton and Extracellular Matrix
- Peptide
- Cell Signaling Enzymes
- ECM ProteinsCytoskeleton and Extracellular Matrix
- Extracellular Matrix
- Extracellular Matrix Peptides (ECM)
- Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology
- Fibronectin Fragments and Analogs
- Matrix Metalloproteinases Products
- Various Peptides
- RGD
