Levocetirizine dihydrochloride
|
|
|
- CAS-Nr.
- 130018-87-0
- Englisch Name:
- Levocetirizine dihydrochloride
- Synonyma:
- LEVOCETIRIZINE 2HCL;LEVOCETIRIZINE HCL;LEVOCETRIZINE DIHYDROCHLORIDE;(R)-Cetirizine diHCl (Levocetirizine diHCl);[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;DDDB;LevocetrizineHCl;Levocetirizine HCI;Levocitirizine 2HCL;LEVOCETIRIZINE DIHCL
- CBNumber:
- CB9135031
- Summenformel:
- C21H27Cl3N2O3
- Molgewicht:
- 461.81
- MOL-Datei:
- 130018-87-0.mol
|
Levocetirizine dihydrochloride Eigenschaften
- Schmelzpunkt:
- 215-220°C
- alpha
- D25 -12.79° (c = 1 in water)
- storage temp.
- room temp
- L?slichkeit
- H2O: ≥23mg/mL
- Aggregatzustand
- powder
- Farbe
- White to Almost white
- Wasserl?slichkeit
- H2O: ≥23mg/mL
- Merck
- 14,2022
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/s3
- InChIKey
- PGLIUCLTXOYQMV-MGIYCFTINA-N
- SMILES
- C(O)(=O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C2=CC=CC=C2)CC1.[H]Cl.[H]Cl |&1:11,r|
- CAS Datenbank
- 130018-87-0(CAS DataBase Reference)
Levocetirizine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.
Allgemeine Beschreibung
Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H
1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine .
Biochem/physiol Actions
Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.
Levocetirizine dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Levocetirizine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 569)Lieferanten
130018-87-0()Verwandte Suche:
- LEVOCETIRIZINE DIHCL
- LEVOCETIRIZINE DIHYDROCHLORIDE
- LevocetrizineHCl
- LEVOCITIRIZINE DIHYDROCHLORIDE
- (R) -2-[2-[4-[(4-Chlorophenyl) phenylmethyl] piperazin-1-yl]ethoxy]acetic acid dihydrochloride
- (2-(4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl)ethoxy)acetic acid dihydrochloride
- Levocitirizine 2HCL
- Levocetirizine dihydrochloride [2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
- 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
- DDDB
- Cetirizine hydrochloride sinistral
- (R)-Form dihydrochloride
- [2-[4-[(R)-(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINYL]ETHOXY]-ACETIC ACID 2HCL
- (R)-Cetirizine (hydrochloride)
- LEVOCETIRIZINE;(R)-CETIRIZINE (HYDROCHLORIDE)
- LevocetirizineDihydrochloride>
- Levocetirizine Dihydrochlorid
- Levocetirizine dihydrochloride USP/EP/BP
- Levocetirizine Hydrochloride Impurities
- Levocetirizine Dihydrochloride Powder
- Levocetirizine D4 DihydrochlorideQ: What is
Levocetirizine D4 Dihydrochloride Q: What is the CAS Number of
Levocetirizine D4 Dihydrochloride Q: What is the storage condition of
Levocetirizine D4 Dihydrochloride
- Levocetirizine DihydrochlorideQ: What is
Levocetirizine Dihydrochloride Q: What is the CAS Number of
Levocetirizine Dihydrochloride Q: What is the storage condition of
Levocetirizine Dihydrochloride
- Levocetirizine Dihydrochloride (1359969)
- (-)-Cetirizine Dihydrochloride
- Xyzal Dihydrochloride
- (R)-Cetirizine DiHCl
- Levocetirizine HCI
- LEVOCETIRIZINE HYDROCHLORIDE IP
- Levocetirizine Dihydrochloride, ≥ 98.0%
- Levocetirizine Dihydrochloride -IHS/IPS
- Levocetirizine dihydrochloride IMpurity
- Levocetirizine Dihydrochloride, 10 mM in DMSO
- (R)-Cetirizine diHCl (Levocetirizine diHCl)
- [2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride
- LEVOCETIRIZINE 2HCL
- LEVOCETIRIZINE HCL
- LEVOCETRIZINE DIHYDROCHLORIDE
- 130018-87-0
- 3008-87-0
- C21H25ClN2O32ClH
- Antibiotics
- Levocitirizine 2HCl
- API
- Histamine receptor
- API's
- Levocetirizine
