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(S)-(+)-1,2-Propanediol

(S)-(+)-1,2-Propanediol Struktur
4254-15-3
CAS-Nr.
4254-15-3
Englisch Name:
(S)-(+)-1,2-Propanediol
Synonyma:
(S)-Propane-1,2-diol;(S)-1,2-PROPANEDIOL;(2S)-1,2-Propanediol;S-1,2-Propancdiol;L-1,2-Propanediol;(S)-(+)-PROPANEDIOL;(+)-1,2-Propanediol;(2S)-propane-1,2-diol;1,2-Propanediol, (S)-;PROPYELENE GLYCOL pure
CBNumber:
CB9145670
Summenformel:
C3H8O2
Molgewicht:
76.09
MOL-Datei:
4254-15-3.mol

(S)-(+)-1,2-Propanediol Eigenschaften

Schmelzpunkt:
-59 °C
alpha 
16 º (c=neat)
Siedepunkt:
186-188 °C765 mm Hg(lit.)
Dichte
1.036 g/mL at 20 °C(lit.)
Brechungsindex
n20/D 1.432(lit.)
Flammpunkt:
225 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
pka
14.49±0.20(Predicted)
Aggregatzustand
Liquid
Farbe
Clear colorless
Wichte
1.04
Explosionsgrenze
2.6-12.6%(V)
Optische Rotation
[α]20/D +16.5°, neat
Wasserl?slichkeit
soluble
Sensitive 
Hygroscopic
Merck 
14,7855
BRN 
1718871
Stabilit?t:
Volatile
InChI
1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
InChIKey
DNIAPMSPPWPWGF-VKHMYHEASA-N
SMILES
C[C@H](O)CO
CAS Datenbank
4254-15-3(CAS DataBase Reference)
NIST chemische Informationen
(S)-(+)-1,2-Propanediol(4254-15-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 36/37/38-22
S-S?tze: 24/25-36/37/39-26
WGK Germany  1
HS Code  29053200
Speicherklasse 10 - Combustible liquids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(S)-(+)-1,2-Propanediol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Colorless to light yellow liqui

Verwenden

(S)-(+)-1,2-Propanediol acts as an organic solvent and diluent used in pharmaceutical preparations. It is also used as a chiral synthetic intermediate and substrate for enzyme studies.

Vorbereitung Methode

Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.

Pharmazeutische Anwendungen

(S)-(+)-1,2-Propanediol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.

Lager

At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.

Inkompatibilit?ten

Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

(S)-(+)-1,2-Propanediol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S)-(+)-1,2-Propanediol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 370)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nantong Provichem Biotech Co., Ltd.
+8617505220108
sales@provichem.cn China 34 58
Nantong Chem-land Co.,Ltd.
+undefined13862903883
sales@chem-land.com China 62 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055
Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-86-13131129325 +8613131129325
sales1@chuanghaibio.com China 5225 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-2158073036
info@dakenam.com China 14014 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21586 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58

4254-15-3()Verwandte Suche:


  • (S)-(+)-1,2-Dihydroxypropane (S)-(+)-Propylene Glycol
  • (S)-(+)-1,2-Propanediol,97%
  • (S)-(+)-1,2-Propanediol,99%
  • 1,2-Propanediol, (S)-
  • (2S)-propane-1,2-diol
  • S-1,2-Propancdiol
  • PROPYELENE GLYCOL pure
  • PROPYLENE GLYCOL extrapure AR
  • (S)-(+)-1,2-Propanediol,96%
  • (S)-(+)-1,2-Propanediol, 96% 5GR
  • (S)-(+)-1,2-Propanediol 96%
  • (S)-(+)-propylene glycero
  • (S)-(+)-1,2-PROPANEDIOL FOR SYNTHESIS
  • (S)-(+)-Propane-1,2-diol
  • L-(+)-PROPYLENE GLYCOL
  • (S)-(+)-PROPANEDIOL
  • (S)-(+)-PROPYLENE GLYCEROL
  • (S)-(+)-PROPYLENE GLYCOL
  • (S)-(+)-1,2-DIHYDROXYPROPANE
  • (S)-(+)-1,2-PROPANEDIOL
  • 1,2-PROPANEDIOL, 1000MG, NEAT
  • ALUMINUM NITRATE NONAHYDRATE 98+% &
  • L-1,2-Propanediol
  • Синонимы: Монопропиленгликоль, 1,2-пропиленгликоль, 1,2-пропандиол, 1,2-диоксипропан метилгликоль, 1,2- дигидроксипропан, пропандиол-1,2, Propylene Glycol, Propane-1,2-diol, Monopropylene Glycol, MPG
  • (S)-(+)-1,2-Propanediol>
  • 1,2-Propanediol, (2S)-
  • (2S)-1,2-Propanediol
  • S-(+)-1.2-propylene glycol
  • 1,2-Propanediol, (S)-(9CI)
  • (+)-1,2-Propanediol
  • (S)-(+)-1,2-Propanediol
  • (S)-(+)-1,2-Propanediol, 98%
  • (S)-1,2-PROPANEDIOL
  • (S)-Propane-1,2-diol
  • 4254-15-3
  • 4253-15-3
  • C3H8O2
  • Organic Building Blocks
  • Polyols
  • Simple Alcohols (Chiral)
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • organic alcohol
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Compound
  • chiral
  • Chiral Compounds
  • Diols
  • bc0001
  • 4254-15-3
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