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Argipressine

Argipressine Struktur
113-79-1
CAS-Nr.
113-79-1
Englisch Name:
Argipressine
Synonyma:
ARGININE VASOPRESSIN;argipressin;AVP;ANTIDIURETIC HORMONE;[ARG8]-VASOPRESSIN (AVP);IFRC;IFNBR;argipressine;Argipression;β-Hypophamine
CBNumber:
CB9205622
Summenformel:
C46H65N15O12S2
Molgewicht:
1084.24
MOL-Datei:
113-79-1.mol

Argipressine Eigenschaften

Dichte
1.59±0.1 g/cm3(Predicted)
Flammpunkt:
113℃
storage temp. 
2-8°C
pka
9.90±0.15(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
PH
~3.5
Biologische Quelle
synthetic (organic)
Optische Rotation
-23.822 (1 mol dm-3 acetic acid)
Wasserl?slichkeit
Water : ≥ 360 mg/mL (332.03 mM)
Sequenz
H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2,(Disulfide bond)
InChIKey
KBZOIRJILGZLEJ-KIIOGHSHNA-N
SMILES
NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20
S-S?tze: 36
WGK Germany  3
HS Code  2937190000
Speicherklasse 10 - Combustible liquids
Toxizit?t TDLo ivn-pig: 40 ng/kg JPETAB 293,852,2000
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
Sicherheit
P261 Einatmen von Staub vermeiden.

Argipressine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20:Gesundheitssch?dlich beim Einatmen.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Hormone (antidiuretic).

Definition

ChEBI: The predominant form of mammalian vasopressin (antidiuretic hormone). It is a nonapeptide containing an arginine at residue 8 and two disulfide-linked cysteines at residues of 1 and 6.

Indications

ADH (vasopressin) is released primarily in response to increases in plasma osmolarity or decreases in blood volume. It produces its antidiuretic activity in the kidney, causing the cortical and medullary parts of the collecting duct to become more permeable to water, thereby increasing water reabsorption, reducing serum osmolarity, and increasing its volume. It produces this effect by binding to a subset of vasopressin receptors called V2 that have relatively high affinity for the hormone. ADH also has actions at sites other than the kidney. V2 receptors also mediate an increase in circulating levels of two proteins involved in blood coagulation: factor VIII and von Willebrand’s factor.At higher concentrations, ADH interacts with V1 receptors to cause a general constriction of most blood vessels. It also interacts with V3 (or V1b) receptors to increase ACTH release, although the major control of ACTH release occurs through corticotropin-releasing hormone.

Allgemeine Beschreibung

Vasopressin tannate (PitressinTannate) is a water-insoluble tannate of vasopressin administeredintramuscularly (1.5–5.0 pressor units daily)for its prolonged duration of action by the slow release ofvasopressin. It is particularly useful for patients who havediabetes insipidus, but it should never be used intravenously.

Hazard

A poison.

Mechanism of action

ADH itself is available for injections (Pitressin) but has a half-life of about 15 minutes. Desmopressin (DDAVP) is an analogue without an amino group at the first amino acid and with D-arginine instead of Larginine. This analogue is more stable and has very little pressor activity. Desmopressin can be given subcutaneously or nasally, and the effects last for 12 hours.

Clinical Use

Because it is stable, desmopressin is preferred for treatments especially if pressor effects are not desired. The primary indication for therapy is central diabetes insipidus, a disorder that results when ADH secretion is reduced and that is characterized by polydipsia, polyuria, and dehydration. Desmopressin is also used to reduce primary nocturnal enuresis, or bedwetting, in children. It is useful in people with mild hemophilia A or with some types of von Willebrand’s disease, in which von Willebrand’s factor is present at low levels. In these cases, desmopressin is given when excessive bleeding occurs or before surgery to help reduce bleeding indirectly by increasing the amounts of coagulation factors. A possible adverse effect of desmopressin is water intoxication if too much is taken.
ADH antagonists, including nonpeptide analogues that may be taken orally, have been developed with specificity for each of the receptor types. In the future, those that block V1 receptors may be useful in treating hypertension, and those that block V2 receptors may be useful in any condition of excessive water retention or hyponatremia, for which so far there is no satisfactory therapeutic treatment.

Sicherheitsprofil

A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Argipressine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Argipressine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 370)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490
info@gihichemicals.com China 49962 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599
info@molchanges.com China 5218 58
Hebei Chuanghai Biotechnology Co., Ltd
+8615350571055
Sibel@chuanghaibio.com China 8738 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971
deasea125996@gmail.com China 2472 58
qingdao future trading Co., Ltd
+86-13335044410
cui56813@163.com China 110 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580
da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd
+8619956560829
justine@zhongda-biotech.com China 286 58
Anhui Zhongda Biotechnology Co., Ltd
+8615689548120
linda@zhongda-biotech.com China 193 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58

113-79-1()Verwandte Suche:


  • [ARG8]-VASOPRESSIN (HUMAN, BOVINE, OVINE, RAT, MOUSE)
  • [ARG8]-VASOPRESSIN
  • BETA-HYPOPHAMINE
  • β-Hypophamine
  • (ARG8)-VASOPRESSIN GRADE VI SOLUTION*APP ROX. 100 I.
  • 8-Argininevasopressin
  • Vasopressin-8-arginine
  • vasopressin tannate
  • [Arg8]-Vasopressin solution
  • β-Hypophamine, Antidiuretic hormone, Arginine vasopressin, AVP
  • [Arg8]Vasopressin (human, mouse, ovine, rat)
  • M.W. 1084.25 C46H65N15O12S2
  • Arg-Vasopressin
  • CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 (DISULFIDE BRIDGE:CYS1-CYS6)
  • 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide, 19-amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hyd
  • 3-(Phenylalanine)-8-arginineoxytocin
  • 8-L-Arginine-vasopressin
  • (ARG-8) Vasapressin
  • VASOPRESSIN, 8-L-ARGININE-
  • Vasopressin (1.71 mg) (8-L-arginine vasopressin) (COLD SHIPMENT REQUIRED)
  • 19-AMino-13-benzyl-7-(carbaMoylMethyl)-4-[2-[[1-[(carbaMoylMethyl)carbaMoyl]-4-guanidinobutyl]carbaMoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionaMide
  • AVP, Argipressin, LeiorMone, Pitressin, (Phe3,Arg8)-Oxytocin, Arginine Antidiuretic HorMone
  • Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bond 1-6)
  • CYFQNCPRG-NH2 (DISULFIDE BRIDGE: 1-6)
  • CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
  • H-CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
  • H-CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2, CYS1,6, CYCLIC
  • H-CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2 (DISULFIDE BRIDGE: 1-6)
  • argipressine
  • VASOPRESSIN (ARG8)
  • Argipressin,Vasopressin,AVP,Arg8-vasopressin, >99%
  • Argipressin, (Arg8)-Vasopressin
  • Argipressin,Vasopressin,AVP,Arg8-vasopressin
  • Acetate Bremelanotide
  • Argipressine USP/EP/BP
  • Argipression
  • (Arg8)-Vasopressin (net)
  • Vasopressin (8-L-arginine vasopressin)
  • Vasopressin (8-L-arginine vasopressin) (COLD SHIPMENT REQUIRED) (1711100)
  • Argpressin Acetate,Argipressine
  • Argipressin acetate (113 79 1(free base)),Argipressin acetate (113791(free base))
  • Argipressin acetate (113-79-1(free base))
  • (Arg8)-Vasopressin (AVP), Vasopressin receptor agonist
  • [Arg8]-Vasopressin solution
  • [Arg8]-Vasopressin (AVP) Peptide
  • [Arg8]-Vasopressin (Human, Bovine, Ovine, Rat, Mouse) (0.5 mg vial)
  • β-Hypophamine
  • IFNBR
  • IFRC
  • Argipressin (Vasopressin)
  • AVP
  • [ARG8]-VASOPRESSIN (AVP)
  • ARGININE VASOPRESSIN
  • argipressin
  • ANTIDIURETIC HORMONE
  • 113-79-1
  • C46H65N15O12S2
  • Cytokines, Growth Factors and Hormones
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