Rubitecan Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC₅₀s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC₅₀s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.

Chemische Eigenschaften

Yellow Amorphous Powder

Definition

ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

Rubitecan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Rubitecan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3618	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +86-18080483897	sales@biopurify.com	China	4616	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	286	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23506	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58

91421-42-0()Verwandte Suche:

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• 9-Nitrocamptothecin (Rubitecan)
• 9-Nitrocamptothecin
• RFS 2000
• 9-NITRO-CPT
• (4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
• RUBETICAN
• RUBITECAN
• orathecin
• CAMPTOTHECIN, 9-NITRO-20(S)-
• Rubitecane
• (4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3,14(4H,-12H)-dione
• 9-NC
• Oratheci
• Rubitecan (RFS 2000)
• 9-Nitrocamptothecin>
• 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
• Rubitecan USP/EP/BP
• Camptothecin Impurity 13
• CAMPTOTHECIN, 9-NITRO-20
• (S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Rubitecan, 10 mM in DMSO
• CAMPTOTHECIN, 9-NITRO-20(S)-(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 9-Nitrocellulose camptothecine
• 9-NITRO-20(S)-CAMPTOTHECIN
• 91421-42-0
• C20H15N3O6
• Anti-cancer & immunity
• API
• Intermediates & Fine Chemicals
• Pharmaceuticals