Bivalirudin trifluoroacetate salt Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anticoagulant; antithrombotic.

Definition

ChEBI: Bivalirudin is a synthetic peptide of 20 amino acids, comprising D-Phe, Pro, Arg, Pro, Gly, Gly, Gly, Gly, Asn, Gly, Asp, Phe, Glu, Glu, Ile, Pro, Glu, Glu, Tyr, and Leu in sequence. A congener of hirudin (a naturally occurring drug found in the saliva of the medicinal leech), it a specific and reversible inhibitor of thrombin, and is used as an anticoagulant. It has a role as an anticoagulant and an EC 3.4.21.5 (thrombin) inhibitor.

Mechanism of action

Bivalirudin is a rapid-onset, short-acting DTI that binds to both the active site and the exosite-1 of thrombin. Unlike lepirudin, bivalirudin is a reversible inhibitor of both free thrombin and thrombin bound to fibrin. This reversibility is possible because the bound bivalirudin undergoes cleavage at the second N-terminal proline to release the portion of the drug bound to the active site. The carboxyl-terminal portion of bivalirudin dissociates from thrombin to regenerate thrombin. Bivalirudin does not bind to plasma protein.

Pharmakokinetik

Bivalirudin is administered via intravenous bolus injection, followed by continuous infusion (Table 31.4). The drug exhibits a rapid onset and a short duration of action. Bivalirudin is eliminated by renal excretion. It has been suggested that dosage adjustments be made in patients with severe renal impairment and in patients undergoing dialysis. Approximately 30% is eliminated unchanged along with proteolytic cleavage products. Because of the reversible nature of bivalirudin the drug exhibits less risk of bleeding than other antithrombotics, and there have been no reported cases of antibody formation to bivalirudin.

Clinical Use

Bivalirudin, a 20-amino-acid peptide, has been approved for use in patients with unstable angina undergoing percutaneous coronary intervention.

Bivalirudin trifluoroacetate salt Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Bivalirudin trifluoroacetate salt Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
AFINE CHEMICALS LIMITED	+86-571-85134551	info@afinechem.com	China	15080	58
Apextide Co Ltd	+8615300650552	info@apextide.com	China	91	58
Forest chemical technology	+86-13854236000; +8613854236000	grant@forestchem.freeqiye.com	China	296	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	264	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	615	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58

128270-60-0()Verwandte Suche:

---

• Bivalirudin, TFA
• BITTERMELONP.E
• Human Bivalirudin
• DPHE-PRO-ARG-PRO-GLY-GLY-GLY-GLY-ASN-GLY-ASP-PHE-GLU-GLU-LLE-PRO-GLU-GLU-TYR-LEU
• Bivalirudin BG 8967, Hirulog, Hirulog I
• BG 8967, Hirulog, Hirulog I
• H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
• Bivalirudin trifluoroacetate salt
• D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-aspariginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine trifluoroacetate
• Hirulog trifluoroacetate salt
• Bivalirudin Trifluoacetate
• Bivalirudinum
• Bivalirudin Trifluoroacetate, >99%
• Bivalirudin(Bivalirudin Trifluoroacetate)
• BG-8967
• Hirulog-1
• L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-
• Trifluoroacetate Elcatonin
• Bivalirudin USP/EP/BP
• Bivalirudin Thrombin Inhibitor
• [3-20] bivalirudinQ: What is [3-20] bivalirudin Q: What is the CAS Number of [3-20] bivalirudin
• BivalirudinQ: What is Bivalirudin Q: What is the CAS Number of Bivalirudin Q: What is the storage condition of Bivalirudin Q: What are the applications of Bivalirudin
• Bivalirudin API
• 4'-Trihydroxyisoflavone
• Than cutting Lu Ding
• Bivalirudin TFA Salt
• H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH trifluoroacetate salt
• Bivarudine
• (S)-4-((S)-2-((S)-2-(2-((S)-2-(2-(2-(2-(2-((S)-1-(D-Phenylalanyl-L-prolyl-L-arginyl)pyrrolidine-2-carboxamido)acetamido)acetamido)acetamido)acetamido)-4-amino-4-oxobutanamido)acetamido)-3-carboxypropanamido)-3-phenylpropanamido)-5-(((S)-4-carboxy-1-(((2S,3S)-1-((S)-2-(((S)-4-carboxy-1-(((S)-4-carboxy-1-(((S)-1-(((S)-1-carboxy-3-methylbutyl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxopentan-2-yl)amino)-1-oxobut
• Bivalirudin (5 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
• BIVALIRUDIN TRIFLUOROACETATE
• BIVALIRUDIN
• Bivalirudin Acetate
• 128270-60-0
• C98H138N24O33
• API
• proteins
• Peptide
• 128270-60-0