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3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat

GUANABENZ ACETATE Struktur
23256-50-0
CAS-Nr.
23256-50-0
Bezeichnung:
3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat
Englisch Name:
GUANABENZ ACETATE
Synonyma:
guanabenz acetate salt;br750;Wytens;WY-8678;FLA-137;Tenelid;Wytensin;Wy 8678 acetate;GUANABENZ ACETATE;GuanabenzAcetate>
CBNumber:
CB9491023
Summenformel:
C10H12Cl2N4O2
Molgewicht:
291.13
MOL-Datei:
23256-50-0.mol

3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat Eigenschaften

Schmelzpunkt:
227-229℃ (decomposition)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
H2O: 11 mg/mL
Aggregatzustand
solid
Farbe
white
Wasserl?slichkeit
water: 5mg/mL
Merck 
14,4558
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C8H8Cl2N4.C2H4O2/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChIKey
MCSPBPXATWBACD-GAYQJXMFSA-N
SMILES
C1(=C(Cl)C=CC=C1Cl)/C=N/NC(=N)N.C(=O)(O)C
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 22-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. MF0382000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2928002500
Speicherklasse 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Giftige Stoffe Daten 23256-50-0(Hazardous Substances Data)
Bildanzeige (GHS) Skull and Crossbones (GHS06)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Verwenden

antihypertensive

Allgemeine Beschreibung

Guanabenz acetate, [(2,6-dichlorobenzylidene)amino]guanidine monoacetate (Wytensin), is acentral 2-adrenergic agonist that reduces the release of norepinephrinefrom the neuron when stimulated. The effect ofthe drug results in decreased sympathetic tone in the heart,kidneys, and peripheral blood vessels. The drug does not produceorthostatic hypotension.

Biologische Aktivit?t

α 2 -adrenergic agonist and IGRS (imidazoline I 2 binding site) selective ligand.

Pharmakokinetik

The oral bioavailability of guanabenz is 70 to 80%. Following an oral dose, the hypotensive effect of guanabenz begins within 1 hour, peaks within 2 to 7 hours, and is diminished within 6 to 8 hours. It has an elimination half-life averaging 4 to 14 hours. The blood pressure response can persist for at least 12 hours. Following IV dosing, guanabenz is distributed into the CNS, with brain concentrations 3 to 70 times higher than concurrent plasma concentrations. Guanabenz is approximately 90% bound to plasma proteins. In patients with hepatic or renal impairment, its elimination half-life may be prolonged.
Guanabenz is metabolized principally by hydroxylation to its inactive metabolite, 4-hydroxyguanabenz, which is eliminated in the urine as its glucuronide (major) and sulfate conjugates. Guanabenz and its inactive metabolites are excreted principally in urine, with approximately 70 to 80% of its oral dose excreted in urine within 24 hours and approximately 10–30% in feces via enterohepatic cycling. Approximately 40% of an oral dose of guanabenz is excreted in urine as 4-hydroxyguanabenz and its glucuronide, and less than 5% is excreted unchanged. The remainder is excreted as unidentified metabolites and their conjugates.

Clinical Use

Overall, the therapeutic applications for guanabenz are similar to those of clonidine and other α2-adrenergic agonists. One advantage for guanabenz is its once-a-day dosing schedule. Guanabenz has been used in diabetic patients with hypertension without adverse effect on the control of or therapy for diabetes, and it has been effective in hypertensive patients with chronic obstructive pulmonary disease, including asthma, chronic bronchitis, or emphysema. Guanabenz has been used alone or in combination with naltrexone in the management of opiate withdrawal in patients physically dependent on opiates and undergoing detoxification. Guanabenz also has been used as an analgesic in a limited number of patients with chronic pain

Nebenwirkungen

Overall, the frequency of adverse effects produced by guanabenz is similar to that produced by clonidine and the other α2-adrenergic agonists, but the incidence is lower. As with the other centrally active sympatholytics (e.g., clonidine), abrupt withdrawal of guanabenz may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe.

3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 176)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Daken Advanced Materials Co.,Ltd
+86-2158073036
info@dakenam.com China 14014 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29792 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Unipharm pharmaceutical industry Co., Ltd
536-8266195 +8613953676784
lee@unipharm-sd.com China 1202 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9996 58
AFINE CHEMICALS LIMITED
+86-571-85134551
info@afinechem.com China 15083 58
Baoji Guokang Healthchem Co., Ltd.
+86-0917-3909592 +86-13892490616
gksales1@gk-bio.com China 9067 58
Dayang Chem (Hangzhou) Co.,Ltd.
+86-0571-88938639 +8617705817739
info@dycnchem.com China 52704 58

23256-50-0(3-[(2,6-Dichlorphenyl)methylen]carbazamidinmonoacetat)Verwandte Suche:


  • ((2,6-dichlorobenzylidene)amino)-guanidinmonoacetate
  • 2-((2,6-dichlorophenyl)methylene)-hydrazinecarboximidamidmonoacetate
  • br750
  • WY-8678
  • [2,6-DICHLOROBENZYLIDENE)-AMINO]GUANIDINE
  • [(2,6-DICHLOROBENZYLIDENE)AMINO]GUANIDINE ACETATE
  • GUANABENZ ACETATE
  • 3-[(2,6-dichlorophenyl)methylene]carbazamidine monoacetate
  • 1-(2,6-dichlorobenzylideneamino)guanidine acetate salt
  • GUANABENZACETATE,USP
  • 1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678
  • FLA-137
  • Wytensin
  • [(2,6-dichlorobenzylidene)amino]-Guanidine monoacetate
  • Guanabenz acetate salt,1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678
  • Guanabenz Acetate (200 mg)
  • HydrazinecarboxiMidaMide, 2-[(2,6-dichlorophenyl)Methylene]-, acetate
  • Tenelid
  • Wy 8678 acetate
  • Wytens
  • Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, acetate (1:1)
  • Guanabenz Acetate, ≥98%
  • Guanabenz Acetate - CAS 23256-50-0 - Calbiochem
  • (E)-2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide acetate
  • GuanabenzAcetate>
  • GUANABENZ ACETATE USP/EP/BP
  • Guanabenz Acetate (BR-750
  • Guanabenz Acetate (1301404)
  • 2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide acetate
  • 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide acetate
  • Guanabenz Acetate, 10 mM in DMSO
  • 1-[(E)-[(2,6-dichlorophenyl)methylidene]amino]guanidine
  • guanabenz acetate salt
  • 23256-50-0
  • C8H8Cl2N4CH3CO2H
  • C8H8Cl2N4C2H4O2
  • Inhibitors
  • WYTENSIN
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