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MC-Val-Cit-PAB

MC-Val-Cit-PAB structure

CAS No.: 159857-80-4

Chemical Name:: MC-Val-Cit-PAB

Synonyms: 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide;MC-Val-Cit-PAB-OH;N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;MC-Val-it-PAB;N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide;EOS-60616;MC-V-Cit-PAB;ML-Val-Cit-PAB;MC-Val-Cit-PAB;MC-Val-Cit-PAB/MC-VC-PAB-OH

CBNumber:: CB02554361

Molecular Formula:: C28H40N6O7

Molecular Weight:: 572.65

MDL Number:: MFCD26142966

MOL File:: 159857-80-4.mol

MSDS File:: SDS

Last updated:2026-07-16 07:06:08

Product description	Number	Pack Size	Price
MC-Val-Cit-PAB-OH	M3224	100MG	$150
MC-Val-Cit-PAB-OH	M3224	500MG	$525
Mc-Val-Cit-PAB ≥98%	28285	1mg	$38
Mc-Val-Cit-PAB ≥98%	28285	5mg	$110
Mc-Val-Cit-PAB ≥98%	28285	10mg	$202
More product size

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MC-Val-Cit-PAB Properties

Boiling point	931.6±65.0 °C(Predicted)
Density	1.276
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO: soluble
form	powder to crystal
pka	13.41±0.70(Predicted)
color	White to Almost white
InChIKey	UMDCMQHPXQLHGR-OFVILXPXSA-N
SMILES	C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
CAS DataBase Reference	159857-80-4
UNSPSC Code	12352209
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

WGK 3

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

MC-Val-Cit-PAB price More Price(92)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3224	MC-Val-Cit-PAB-OH	159857-80-4	100MG	$150	2026-04-30	Buy
TCI Chemical	M3224	MC-Val-Cit-PAB-OH	159857-80-4	500MG	$525	2026-04-30	Buy
Cayman Chemical	28285	Mc-Val-Cit-PAB ≥98%	159857-80-4	1mg	$38	2026-04-30	Buy
Cayman Chemical	28285	Mc-Val-Cit-PAB ≥98%	159857-80-4	5mg	$110	2026-04-30	Buy
Cayman Chemical	28285	Mc-Val-Cit-PAB ≥98%	159857-80-4	10mg	$202	2026-04-30	Buy

Product number	Packaging	Price	Buy
M3224	100MG	$150	Buy
M3224	500MG	$525	Buy
28285	1mg	$38	Buy
28285	5mg	$110	Buy
28285	10mg	$202	Buy

MC-Val-Cit-PAB Chemical Properties,Uses,Production

Description

MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety

Uses

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.

Application

MC-Val-Cit-PAB is a peptide linker that can be used to prepare antibody-drug conjugates (ADCs) for cancer therapy research. For example, CBP-1018, a dual-ligand PDC, is conjugated to MMAE via a cleavable linker (MC-Val-Cit-PABC) that can be cleaved by proteinase B^[1]. MC-Val-Cit-PAB can also be used to prepare cetuximab-vc-DOX-NPs conjugates, which have good tumor targeting ability and low systemic toxicity, and are a promising drug delivery targeting system^[2^].

References

[1] LC-MS/MS method for dual-ligand peptide-drug CBP-1018 and its deconjugated payload MMAE including sample stabilization strategy for its MC-Val-Cit-PABC linker[J]. Talanta, 2024. DOI:10.1016/j.talanta.2024.126596.
[2] ZIXUAN YE. EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy.[J]. International Journal of Nanomedicine, 2021. DOI:10.2147/IJN.S289228.

MC-Val-Cit-PAB synthesis

Synthesis of MC-Val-Cit-PAB from N-Succinimidyl 6-maleimidohexanoate and Val-cit-PAB-OH

MC-Val-Cit-PAB Preparation Products And Raw materials

Raw materials

N-Succinimidyl 6-maleimidohexanoate 4-Aminobenzyl alcohol Val-cit-PAB-OH 6-Maleimidocaproic acid-PFP ester H-Cit-PABA

6-Maleimidocaproic acid FMOC-L-Valine L-Citrulline Fmoc-Val-Cit-OH FMOC-VAL-OSU

FMoc-Val-Cit-PAB 6-Aminocaproic acid

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Preparation Products

Mc-Val-Cit-PABC-PNP

MC-Val-Cit-PAB Suppliers

Global( 229)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	790	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21193	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5746	58

Supplier	Advantage
ChemExpress	58
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
BOC Sciences	58
Jurong Coupling Biotechnology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from MC-Val-Cit-PAB manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	MC-Val-Cit-PAB 159857-80-4	$29.00-30.00		98.24%	10g	TargetMol Chemicals Inc.
2025-06-07	MC-Val-Cit-PAB-OH 159857-80-4		1g	>98.00%	1g	Xian confluore Biological Technology Co., Ltd.
2020-01-09	N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 159857-80-4	$6.68	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

MC-Val-Cit-PAB
159857-80-4
$29.00-30.00
98.24%
TargetMol Chemicals Inc.

MC-Val-Cit-PAB-OH
159857-80-4
$0.00
>98.00%
Xian confluore Biological Technology Co., Ltd.

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
159857-80-4
$6.68
97%-99%
Career Henan Chemical Co

MC-Val-Cit-PAB Spectrum

MC-Val-Cit-PAB(159857-80-4)¹HNMR

159857-80-4(MC-Val-Cit-PAB)Related Search:

FMoc-Val-Cit-PAB-PNP Val-cit-PAB-OH pyrene-2,7-diyldiboronic acid Fmoc-Val-Cit-OH FMoc-Val-Cit-PAB

Mal-amide-PEG8-Val-Cit-PAB-OH

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L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]- ML-Val-Cit-PAB MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- MC-Val-Cit-PAB EOS-60616 N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N⁵-carbamoyl-N²-[4-(hydroxymethyl)phenyl]-L-ornithinamide Benzenemethanol,2-chloro-8-nitro- MC-Val-Cit-PAB (ADC peptide linker) 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide MC-Val-Cit-PAB/MC-VC-PAB-OH N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide Peptide Linkers（ADC Linkers）：MC-Val-Cit-PAB-OH N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 98+ MC-V-Cit-PAB 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide MC-Val-Cit-PAB-OH MC-Val-it-PAB N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide 159857-80-4 59857-80-4 C28H40N6O7 ADCs ADC Linker ADC-Linker ADC-Linkers

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