MC-Val-Cit-PAB-OH
MC-Val-Cit-PAB-OH 物理性質(zhì)
- 沸點 :
- 931.6±65.0 °C(Predicted)
- 比重(密度) :
- 1.276
- 貯蔵溫度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 溶解性:
- DMSO: soluble
- 外見 :
- powder to crystal
- 酸解離定數(shù)(Pka):
- 13.41±0.70(Predicted)
- 色:
- White to Almost white
- InChIKey:
- UMDCMQHPXQLHGR-OFVILXPXSA-N
- SMILES:
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1
- CAS データベース:
- 159857-80-4
安全性情報
- リスクと安全性に関する聲明
- 危険有害性情報のコード(GHS)
| WGK Germany |
WGK 3 |
|
|
| ストレージクラス |
11 - Combustible Solids |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標(biāo)的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P305+P351+P338 |
眼に入った場合：水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
MC-Val-Cit-PAB-OH 価格
もっと(2)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時間 |
購入 |
|
東京化成工業(yè)
|
M3224 |
>98.0%(HPLC)(N)
MC-Val-Cit-PAB-OH >98.0%(HPLC)(N) |
159857-80-4 |
100MG |
￥21000 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
M3224 |
>98.0%(HPLC)(N)
MC-Val-Cit-PAB-OH >98.0%(HPLC)(N) |
159857-80-4 |
500MG |
￥73500 |
2024-03-01 |
購入 |
MC-Val-Cit-PAB-OH 化學(xué)特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結(jié)晶
使用
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.
主な応用
MC-Val-Cit-PAB is a peptide linker that can be used to prepare antibody-drug conjugates (ADCs) for cancer therapy research. For example, CBP-1018, a dual-ligand PDC, is conjugated to MMAE via a cleavable linker (MC-Val-Cit-PABC) that can be cleaved by proteinase B
[1].
MC-Val-Cit-PAB can also be used to prepare cetuximab-vc-DOX-NPs conjugates, which have good tumor targeting ability and low systemic toxicity, and are a promising drug delivery targeting system
[2].
MC-Val-Cit-PAB-OH 上流と下流の製品情報
原材料
準(zhǔn)備製品
MC-Val-Cit-PAB-OH 生産企業(yè)
Global( 229)Suppliers
MC-Val-Cit-PAB-OH スペクトルデータ(1HNMR)
159857-80-4(MC-Val-Cit-PAB-OH)キーワード:
- 159857-80-4
- L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-
- ML-Val-Cit-PAB
- MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
- MC-Val-Cit-PAB
- EOS-60616
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth
- N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureidopentan-2-yl]amino]-3-methyl-1-ox
- 6-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)-N-[(S)-1-[[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-5-ureido-2-pentyl]amino]-3-methyl-1-oxo-2-butyl]hexanamide
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- Benzenemethanol,2-chloro-8-nitro-
- MC-Val-Cit-PAB (ADC peptide linker)
- 6-(2,5-dioxopyrrol-1-yl)-N-[(1S)-1-[[(1S)-1-[[4-(hydroxymethyl)phenyl]carbamoyl]-4-ureido-butyl]carbamoyl]-2-methyl-propyl]hexanamide
- MC-Val-Cit-PAB/MC-VC-PAB-OH
- N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N2-[4-(hydroxymethyl)phenyl]-L-ornithinamide
- Peptide Linkers（ADC Linkers）：MC-Val-Cit-PAB-OH
- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide 98+
- MC-V-Cit-PAB
- 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
- MC-Val-Cit-PAB-OH
- MC-Val-it-PAB
- N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
- MC-Val-Cit-PAB-OH