DBeQ
- CAS No.
- 177355-84-9
- Chemical Name:
- DBeQ
- Synonyms
- JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;DBEQ, 10 mM in DMSO;JRF 12; JRF12; JRF-12;DBeQ, p97 ATPase inhibitor;N,N'-Dibenzylquinazoline-2,4-diamine
- CBNumber:
- CB02569682
- Molecular Formula:
- C22H20N4
- Molecular Weight:
- 340.42
- MDL Number:
- MFCD03691820
- MOL File:
- 177355-84-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DBeQ ≥98% (HPLC) | SML0031 | 5mg | $122 |
| DBeQ ≥98% (HPLC) | SML0031 | 25mg | $497 |
| DBeQ >98.0%(HPLC) | D5476 | 25mg | $75 |
| DBeQ >98.0%(HPLC) | D5476 | 100mg | $222 |
| DBeQ ≥98% | 15318 | 5mg | $95 |
| More product size | |||
| Melting point | 149 °C |
|---|---|
| Boiling point | 573.1±52.0 °C(Predicted) |
| Density | 1.259±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 7.78±0.30(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChI | 1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26) |
| InChIKey | QAIMUUJJAJBPCL-UHFFFAOYSA-N |
| SMILES | C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4 |
| CAS DataBase Reference | 177355-84-9 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
DBeQ price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0031 | DBeQ ≥98% (HPLC) | 177355-84-9 | 5mg | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0031 | DBeQ ≥98% (HPLC) | 177355-84-9 | 25mg | $497 | 2026-04-30 | Buy |
| TCI Chemical | D5476 | DBeQ >98.0%(HPLC) | 177355-84-9 | 25mg | $75 | 2026-04-30 | Buy |
| TCI Chemical | D5476 | DBeQ >98.0%(HPLC) | 177355-84-9 | 100mg | $222 | 2026-04-30 | Buy |
| Cayman Chemical | 15318 | DBeQ ≥98% | 177355-84-9 | 5mg | $95 | 2026-04-30 | Buy |
DBeQ Chemical Properties,Uses,Production
Description
DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
Uses
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
Uses
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
storage
Store at +4°C
References
[1] TSUI-FEN CHOU. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011: 4834-4839. DOI:10.1073/pnas.1015312108
DBeQ Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5746 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-86-15536356810 +8617392712697 | 1022@dideu.com | China | 29095 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10457 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
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