LDC1267
- CAS No.
- 1361030-48-9
- Chemical Name:
- LDC1267
- Synonyms
- CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC1267, 10 mM in DMSO;TAM Receptor Kinase Inhibitor, LDC1267;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
- CBNumber:
- CB02734808
- Molecular Formula:
- C30H26F2N4O5
- Molecular Weight:
- 560.55
- MDL Number:
- MFCD28385861
- MOL File:
- 1361030-48-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| LDC-1267 ≥98% | 29459 | 1mg | $28 |
| LDC-1267 ≥98% | 29459 | 5mg | $76 |
| LDC-1267 ≥98% | 29459 | 10mg | $138 |
| LDC-1267 ≥98% | 29459 | 25mg | $275 |
| LDC-1267 | 29459 | 1mg | $36 |
| More product size | |||
| Boiling point | 628.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO |
| form | solid |
| pka | 9.36±0.70(Predicted) |
| color | White to off-white |
| InChIKey | ISPBCAXOSOLFME-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=C(F)C=C2C)C=C(OCC)C(C(NC2=CC=C(OC3C4C(N=CC=3)=CC(OC)=C(OC)C=4)C(F)=C2)=O)=N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
LDC1267 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29459 | LDC-1267 ≥98% | 1361030-48-9 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 29459 | LDC-1267 ≥98% | 1361030-48-9 | 5mg | $76 | 2026-04-30 | Buy |
| Cayman Chemical | 29459 | LDC-1267 ≥98% | 1361030-48-9 | 10mg | $138 | 2026-04-30 | Buy |
| Cayman Chemical | 29459 | LDC-1267 ≥98% | 1361030-48-9 | 25mg | $275 | 2026-04-30 | Buy |
| Cayman Chemical | 29459 | LDC-1267 | 1361030-48-9 | 1mg | $36 | 2024-03-01 | Buy |
LDC1267 Chemical Properties,Uses,Production
Uses
LDC1267 is a highly selective TAM (Tyro3, Axl and Mer) kinase inhibitor with IC50s of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively[1].
Biological Activity
LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
in vitro
LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.
in vivo
In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
target
| Target | Value |
| Mer (Cell-free assay) | <5 nM |
| Tyro3 (Cell-free assay) | 8 nM |
| Axl (Cell-free assay) | 29 nM |
IC 50
Axl; Tyro3; Mer
References
[1] Paolino M, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12. DOI:10.1038/nature12998
LDC1267 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24597 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +86-18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
