(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- CAS No.
- 127910-31-0
- Chemical Name:
- (E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- Synonyms
- CGP 37849;CGP 37849;CGP-37849;CGP37849;CGP 37849, competitive NMDA antagonist;dl-2-amino-4-methyl-5-phosphono-3-*pentenoic acid;(E)-2-Amino-4-methyl-5-phosphonopent-3-enoic acid;(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid;(E)-(±)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-;(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
- CBNumber:
- CB0334453
- Molecular Formula:
- C6H12NO5P
- Molecular Weight:
- 209.14
- MDL Number:
- MFCD00153906
- MOL File:
- 127910-31-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CGP 37849 ≥98% (HPLC) | SML0050 | 5mg | $79.7 |
| CGP 37849 ≥98% (HPLC) | SML0050 | 25mg | $468 |
| CGP 37849 | 5.04842 | 10 mg | $121 |
| CGP 37849 ≥95% | 43660 | 5mg | $82 |
| CGP 37849 ≥95% | 43660 | 10mg | $156 |
| Boiling point | 523.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.506±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | H2O: ≥2mg/mL (warmed) |
| form | powder |
| pka | 1.83±0.10(Predicted) |
| color | white to beige |
| Water Solubility | H2O: 100mM |
| InChI | 1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+ |
| InChIKey | BDYHNCZIGYIOGJ-DUXPYHPUSA-N |
| SMILES | C\C(CP(O)(O)=O)=C/C(N)C(O)=O |
| FDA UNII | 76IND1BS43 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0050 | CGP 37849 ≥98% (HPLC) | 127910-31-0 | 5mg | $79.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0050 | CGP 37849 ≥98% (HPLC) | 127910-31-0 | 25mg | $468 | 2026-04-30 | Buy |
| Sigma-Aldrich | 5.04842 | CGP 37849 | 127910-31-0 | 10 mg | $121 | 2026-04-30 | Buy |
| Cayman Chemical | 43660 | CGP 37849 ≥95% | 127910-31-0 | 5mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 43660 | CGP 37849 ≥95% | 127910-31-0 | 10mg | $156 | 2026-04-30 | Buy |
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID Chemical Properties,Uses,Production
Uses
CGP 37849 is a potent antagonist at NMDA receptors which results in anticonvulsant activity (1). In addition, it may antagonize NMDA-antagonistic induced antianxiety effects (2).
Biological Activity
Potent, selective and competitive NMDA receptor antagonist (K i = 35 nM). Anticonvulsive following oral administration in vivo .
in vivo
CGP 37849 potently (Ki of 220 nM) and competitively inhibits NMDA-sensitive l-[3H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [3H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a Ki of 35 nM[1].
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate[1].
Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg[1].
IC 50
NMDA Receptor
storage
Desiccate at +4°C
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9947 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +8618913958656 | inquiries@moldeep.com | China | 19983 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
