4-METHOXYBENZENESULFONYL HYDRAZIDE
- CAS No.
- 1950-68-1
- Chemical Name:
- 4-METHOXYBENZENESULFONYL HYDRAZIDE
- Synonyms
- 4-methoxybenzenesulfonohydrazide;p-Anisolesulphonyl hydrazide;p-Methoxybenzenesulfonohydrazide;4-Methoxybenzenesulphonohydrazide;4-METHOXYBENZENESULFONYL HYDRAZIDE;p-methoxybenzenesulphonyl hydrazide;4-METHOXYBENZENESULPHONYL HYDRAZIDE;4-methoxybenzene-1-sulfonohydrazide;4-Methoxybenzenesulfonyl hydrazide, 98+%;4-METHOXYBENZENESULFONYL HYDRAZIDE, 97+%
- CBNumber:
- CB0712318
- Molecular Formula:
- C7H10N2O3S
- Molecular Weight:
- 202.23
- MDL Number:
- MFCD00014751
- MOL File:
- 1950-68-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-METHOXYBENZENESULFONOHYDRAZIDE AldrichCPR | S172073 | 50MG | $28.6 |
| 4-Methoxybenzenesulfonohydrazide | M3845 | 1G | $46 |
| 4-Methoxybenzenesulfonohydrazide | M3845 | 5G | $137 |
| 4-Methoxybenzenesulfonyl hydrazide 97% | AS216307 | 1g | $28 |
| 4-Methoxybenzenesulfonyl hydrazide 97% | AS216307 | 5g | $48 |
| Melting point | 111-114 °C(lit.) |
|---|---|
| Boiling point | 369.4±44.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.27±0.10(Predicted) |
| form | powder |
| color | White |
| BRN | 2694939 |
| CAS DataBase Reference | 1950-68-1(CAS DataBase Reference) |
| FDA UNII | JLC84M74XM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | 3226 |
| WGK Germany | 3 |
| HazardClass | 4.1 |
| HazardClass | IRRITANT |
| HS Code | 29280000 |
4-METHOXYBENZENESULFONYL HYDRAZIDE price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S172073 | 4-METHOXYBENZENESULFONOHYDRAZIDE AldrichCPR | 1950-68-1 | 50MG | $28.6 | 2022-05-15 | Buy |
| TCI Chemical | M3845 | 4-Methoxybenzenesulfonohydrazide | 1950-68-1 | 1G | $46 | 2026-04-30 | Buy |
| TCI Chemical | M3845 | 4-Methoxybenzenesulfonohydrazide | 1950-68-1 | 5G | $137 | 2026-04-30 | Buy |
| Activate Scientific | AS216307 | 4-Methoxybenzenesulfonyl hydrazide 97% | 1950-68-1 | 1g | $28 | 2026-06-04 | Buy |
| Activate Scientific | AS216307 | 4-Methoxybenzenesulfonyl hydrazide 97% | 1950-68-1 | 5g | $48 | 2026-06-04 | Buy |
4-METHOXYBENZENESULFONYL HYDRAZIDE Chemical Properties,Uses,Production
Definition
ChEBI: 4-Methoxybenzenesulfonohydrazide is a sulfonamide.
Synthesis
98-68-0
1950-68-1
The general procedure for the synthesis of 4-methoxybenzenesulfonyl hydrazide from p-methoxybenzenesulfonyl chloride is as follows: Hydrazine hydrate (2.5 eq.) was added slowly and dropwise to a solution of tetrahydrofuran (THF, 0.2 M) of p-methoxybenzenesulfonyl chloride (1.0 eq.) at 0 °C. The reaction mixture was stirred continuously at 0 °C until thin layer chromatography (TLC) analysis showed complete reaction. Subsequently, the reaction mixture was diluted with ethyl acetate (EtOAc), washed sequentially with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent to give the crude p-methoxybenzenesulfonyl hydrazide. The p-methoxybenzenesulfonyl hydrazide (1.0 eq.) was dissolved in methanol (MeOH, 0.5 M) and the corresponding ketone (1.0 eq.) was added. The reaction mixture was stirred at room temperature until TLC monitoring showed that the reaction was complete. The solvent was removed under reduced pressure to give p-methoxybenzenesulfonylhydrazone. The p-methoxybenzenesulfonylhydrazone (0.5 mmol, 1.0 eq.), boric acid (0.75 mmol, 1.5 eq.), and cesium carbonate (0.75 mmol, 1.5 eq.) were placed in a reaction tube that had been pre-dried in an oven and evacuated, and kept for 30 minutes. Subsequently, the reaction tube was filled with argon for protection and dry and degassed 1,4-dioxane (2 mL, 0.25 M) was added. The reaction tube was sealed and the reaction was heated at 110°C for 18 hours. Upon completion of the reaction, the reaction was cooled to room temperature, quenched with saturated aqueous sodium bicarbonate (NaHCO3) (2 mL) and extracted with dichloromethane (CH2Cl2, 3 x 5 mL). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the crude product. Finally, the target product 4-methoxybenzenesulfonyl hydrazide was purified by fast column chromatography (eluent: 10% to 30% ethyl acetate/hexane gradient elution).
References
[1] Marine Drugs, 2016, vol. 14, # 5,
[2] RSC Advances, 2016, vol. 6, # 96, p. 93476 - 93485
[3] Tetrahedron, 2017, vol. 73, # 49, p. 6871 - 6879
[4] Journal of Organic Chemistry, 2014, vol. 79, # 1, p. 328 - 338
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4629 - 4636
4-METHOXYBENZENESULFONYL HYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-METHOXYBENZENESULFONYL HYDRAZIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| JIAXING REGEN CHEMICAL CO.,LTD | +8613385739570 | regen_chemical1@163.com | China | 226 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
View Lastest Price from 4-METHOXYBENZENESULFONYL HYDRAZIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-08-12 | 4-METHOXYBENZENESULFONYL HYDRAZIDE
1950-68-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-METHOXYBENZENESULFONYL HYDRAZIDE
1950-68-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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