Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
- CAS No.
- 4099-85-8
- Chemical Name:
- Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
- Synonyms
- Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside;((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol;NSC 85191;EINECS 223-865-8;Capecitabine Impurity 32;Capecitabine Impurity 55;2,3-O-Isopropylidene-B-D-ribofuranoside;METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE;(3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-te;2,3-O-isopropylidine-1-O-methylribofuranose
- CBNumber:
- CB1140967
- Molecular Formula:
- C9H16O5
- Molecular Weight:
- 204.22
- MDL Number:
- MFCD00270040
- MOL File:
- 4099-85-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 % | M3528 | 1G | $22 |
| Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 % | M3528 | 5G | $74 |
| Methyl 2,3-O-Isopropylidene-Beta-D-ribofuranoside | TRC-M314600-5G | 5g | $72 |
| Methyl 2,3-O-isopropylidene-β-D-ribofuranoside | MM03771 | 25g | $240.75 |
| Methyl 2,3-O-isopropylidene-β-D-ribofuranoside | MM03771 | 50g | $405 |
| More product size | |||
| Boiling point | 75°C/0.3mm |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in chloroform, dichloromethane, ethanol, ethyl acetate, and methanol |
| form | Oil |
| pka | 14.14±0.10(Predicted) |
| color | Clear Yellow |
| InChI | InChI=1/C9H16O5/c1-9(2)13-6-5(4-10)12-8(11-3)7(6)14-9/h5-8,10H,4H2,1-3H3/t5-,6-,7-,8-/s3 |
| InChIKey | DXBHDBLZPXQALN-OVDRDRJSNA-N |
| SMILES | C([C@H]1O[C@@H](OC)[C@]2([H])OC(C)(C)O[C@]12[H])O |&1:1,3,6,13,r| |
| CAS DataBase Reference | 4099-85-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2940006000 |
Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3528 | Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 % | 4099-85-8 | 1G | $22 | 2026-04-30 | Buy |
| TCI Chemical | M3528 | Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside min. 98.0 % | 4099-85-8 | 5G | $74 | 2026-04-30 | Buy |
| TRC | TRC-M314600-5G | Methyl 2,3-O-Isopropylidene-Beta-D-ribofuranoside | 4099-85-8 | 5g | $72 | 2026-06-03 | Buy |
| Biosynth | MM03771 | Methyl 2,3-O-isopropylidene-β-D-ribofuranoside | 4099-85-8 | 25g | $240.75 | 2026-06-04 | Buy |
| Biosynth | MM03771 | Methyl 2,3-O-isopropylidene-β-D-ribofuranoside | 4099-85-8 | 50g | $405 | 2026-06-04 | Buy |
Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Chemical Properties,Uses,Production
Chemical Properties
Colourless Liquid
Uses
Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside is used for the manufacture of fine chemicals, and Industrial use resulting in manufacture of intermediates.
Synthesis
67-56-1
532-20-7
67-64-1
4099-85-8
D-ribose (1; 20.0 g, 133.2 mmol) was suspended in a solvent mixture of acetone (100 mL) and methanol (100 mL) at room temperature. Concentrated sulfuric acid (10 mL) was slowly added and the reaction mixture was stirred for 48 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, solid sodium bicarbonate (NaHCO3) was added to neutralize the reaction solution. The insoluble solids were removed by filtration and the filtrate was subsequently concentrated. The concentrated mixture was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent was evaporated to remove the organic solvent. The crude product was purified by silica gel fast column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target compound ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxin-4-yl)methanol as a light yellow oil in 24.4 g (90% yield). The Rf value of the product was 0.2 (eluent: hexane/EtOAc = 5:1, v/v). The specific optical rotation [α]D25 was -80.00 (c 1.00, CHCl3), which is in accordance with the literature value [α]D20 -75.00 (c 1.00, CHCl3).1H NMR (CDCl3, 400 MHz) data were as follows: δ= 4.97 (s, 1H), 4.83 (d, J = 5.7Hz, 1H), 4.58 (d, J = 6.0 Hz, 1H), 4.42 (t, J = 2.7 Hz, 1H), 3.56-3.72 (m, 2H), 3.43 (s, 3H), 3.32 (dd, J = 10.0,3.0 Hz, 1H), 1.49 (s, 3H), 1.32 (s, 3H).
References
[1] Synthesis (Germany), 2017, vol. 49, # 18, p. 4299 - 4302
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 7972 - 7990
[3] Journal of the American Chemical Society, 2015, vol. 137, # 10, p. 3558 - 3564
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 4, p. 761 - 776
[5] Journal of Fluorine Chemistry, 1993, vol. 60, # 2.3, p. 239 - 250
Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Affinity（Wuhan）Ltd. | +86-+undefined-0411-39805809 +86-+undefined-15841022315 | sales@affinitytech.cn | China | 126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2021-08-12 | Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | Methyl-2,3-O–isopropylidene-β-D- ribofuranoside
4099-85-8
|
$90.00-100.00 | 1KG | 99% | 10kg/month or Customized | Career Henan Chemical Co |
-
- Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
4099-85-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Methyl-2,3-O–isopropylidene-β-D- ribofuranoside
4099-85-8
- $90.00-100.00
- 99%
- Career Henan Chemical Co
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