UNC-0642
- CAS No.
- 1481677-78-4
- Chemical Name:
- UNC-0642
- Synonyms
- UNC 0642;CS-1714;UNC0642;UNC-0642;UNC0642 ，S7230;UNC0642, 10 mM in DMSO;UNC-0642;UNC0642;UNC 0642;UNC0642,inhibit,Inhibitor,Histone Methyltransferase;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine
- CBNumber:
- CB12668368
- Molecular Formula:
- C29H44F2N6O2
- Molecular Weight:
- 546.7
- MDL Number:
- MFCD28044322
- MOL File:
- 1481677-78-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| UNC0642 ≥98% (HPLC) | SML1037 | 5mg | $238 |
| UNC0642 ≥98% (HPLC) | SML1037 | 25mg | $953 |
| UNC0642 ≥95% | 14604 | 1mg | $69 |
| UNC0642 ≥95% | 14604 | 5mg | $198 |
| UNC0642 ≥95% | 14604 | 10mg | $297 |
| More product size | |||
| Boiling point | 679.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| pka | 10.06±0.20(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | RNAMYOYQYRYFQY-UHFFFAOYSA-N |
| SMILES | FC(CC1)(F)CCN1C2=NC(NC3CCN(C(C)C)CC3)=C4C(C=C(OCCCN5CCCC5)C(OC)=C4)=N2 |
| FDA UNII | 3DG5AHY932 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
UNC-0642 price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1037 | UNC0642 ≥98% (HPLC) | 1481677-78-4 | 5mg | $238 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1037 | UNC0642 ≥98% (HPLC) | 1481677-78-4 | 25mg | $953 | 2026-04-30 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 1481677-78-4 | 1mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 1481677-78-4 | 5mg | $198 | 2026-04-30 | Buy |
| Cayman Chemical | 14604 | UNC0642 ≥95% | 1481677-78-4 | 10mg | $297 | 2026-04-30 | Buy |
UNC-0642 Chemical Properties,Uses,Production
Uses
UNC 0642 is an in vivo chemical probe of the lysine methyltransferases G9a and GLP which maintains high in vitro and cellular potency, low cell toxicity, and selectivity.
Biochem/physiol Actions
UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
in vivo
A single intraperitoneal (IP) injection (5 mg/kg) of UNC0642 results in a plasma Cmax (maximum concentration) of 947 ng/mL and an AUC (area under the curve) of 1265 hr*ng/mL[1].
IC 50
EHMT2/G9a/KMT1C; EHMT1/GLP/KMT1D
storage
Store at -20°C
UNC-0642 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +86-519-85525359 +86-15995072465 | sales@xuanmingchem.com | China | 912 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24597 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
