Streptonigrin
- CAS No.
- 3930-19-6
- Chemical Name:
- Streptonigrin
- Synonyms
- NIGRIN;5278r.p.;nsc45383;NSC 83950;NSC 56748;valacidin;phaeomycin;BRUNEOMYCIN;AO 50165L302;streptonigran
- CBNumber:
- CB1333569
- Molecular Formula:
- C25H22N4O8
- Molecular Weight:
- 506.46
- MDL Number:
- MFCD00063401
- MOL File:
- 3930-19-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Streptonigrin from Streptomyces flocculus ≥98% | S1014 | 1mg | $130 |
| Streptonigrin from Streptomyces flocculus ≥98% | S1014 | 5mg | $476 |
| Streptonigrin ≥95% | 27952 | 1mg | $130 |
| Streptonigrin ≥95% | 27952 | 5mg | $582 |
| Streptonigrin | 27952 | 1mg | $118 |
| More product size | |||
| Melting point | 301-303℃ |
|---|---|
| Boiling point | 595.12°C (rough estimate) |
| Density | 1.4130 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform:Methanol (1:1): 2 mg/ml |
| form | A solid |
| pka | 6.2-6.4 (1:1 aq dioxane) |
| color | Light brown to brown |
| Merck | 13,8907 |
| BRN | 599390 |
| InChI | 1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34) |
| InChIKey | PVYJZLYGTZKPJE-UHFFFAOYSA-N |
| SMILES | COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O |
| FDA UNII | 261Q3JB310 |
| NCI Drug Dictionary | streptonigrin |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 53-28-36/37/39-45 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TJ7350000 | |||||||||
| F | 10-18 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 1 Oral | |||||||||
| Toxicity | LD50 oral in mouse: 2330ug/kg | |||||||||
| NFPA 704 |
|
Streptonigrin price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 3930-19-6 | 1mg | $130 | 2026-04-30 | Buy |
| Sigma-Aldrich | S1014 | Streptonigrin from Streptomyces flocculus ≥98% | 3930-19-6 | 5mg | $476 | 2026-04-30 | Buy |
| Cayman Chemical | 27952 | Streptonigrin ≥95% | 3930-19-6 | 1mg | $130 | 2026-04-30 | Buy |
| Cayman Chemical | 27952 | Streptonigrin ≥95% | 3930-19-6 | 5mg | $582 | 2026-04-30 | Buy |
| Cayman Chemical | 27952 | Streptonigrin | 3930-19-6 | 1mg | $118 | 2024-03-01 | Buy |
Streptonigrin Chemical Properties,Uses,Production
Description
Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities. Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner. It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine and orthophenanthroline. Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed. Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner. In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.
Chemical Properties
Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions.
Uses
Streptonigrin is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Streptonigrin from Streptomyces flocculus
Uses
Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).
Definition
ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
brand name
Nigrin (Pfizer).
Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.
Purification Methods
Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961].
References
[1] Y YAMASHITA. Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin.[J]. Cancer research, 1990, 50 18: 5841-5844.
[2] MYRON LEVINE Marcene B. The action of streptonigrin on bacterial DNA metabolism and on induction of phage production in lysogenic bacteria[J]. Virology, 1963, 21 4: Pages 568-574. DOI: 10.1016/0042-6822(63)90228-9
[3] HEATHER Y. YEOWELL J R W. Iron Requirement in the Bactericidal Mechanism of Streptonigrin[J]. Antimicrobial Agents and Chemotherapy, 1983, 23 1: 512-512. DOI: 10.1128/aac.23.3.512
[4] HOWARD D. BEALL . Role of NAD(P)H:Quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin[J]. Biochemical pharmacology, 1996, 51 5: Pages 645-652. DOI: 10.1016/s0006-2952(95)00223-5
[5] M M COHEN A P C M W SHAW. The effects of streptonigrin on cultured human leukocytes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1963, 50: 16-24. DOI: 10.1073/pnas.50.1.16
[6] T J MCBRIDE D W J J Oleson. The activity of streptonigrin against the Rauscher murine leukemia virus in vivo.[J]. Cancer research, 1966, 26 4: 727-732.
Streptonigrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3957 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-13119157289 | 18791163155@163.com | China | 3397 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from Streptonigrin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-15 | Streptonigrin
3930-19-6
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-05-03 | Streptonigrin
3930-19-6
|
1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | BRUNEOMYCIN
3930-19-6
|
$1.00 | 1kg | 99% | 100KG | Career Henan Chemical Co |
-
- Streptonigrin
3930-19-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Streptonigrin
3930-19-6
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- BRUNEOMYCIN
3930-19-6
- $1.00
- 99%
- Career Henan Chemical Co
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