4-Methoxy-3-nitropyridine
- CAS No.
- 31872-62-5
- Chemical Name:
- 4-Methoxy-3-nitropyridine
- Synonyms
- CBI-BB ZERO/004611;4-Metho×y-3-nitropyridine;3-Nitro-4-Methoxypyridine;4-METHOXY-3-NITROPYRIDINE;Pyridine,4-methoxy-3-nitro-;4-Methoxy-3-nitropyridine>4-Methoxy-3-nitropyridine ,98%;Methyl 3-nitro-4-pyridinyl ether;4-Methoxy-3-nitropyridine ISO 9001：2015 REACH
- CBNumber:
- CB1700338
- Molecular Formula:
- C6H6N2O3
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD00209661
- MOL File:
- 31872-62-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Methoxy-3-nitropyridine 97% | 734209 | 1g | $64.2 |
| 4-Methoxy-3-nitropyridine 97% | 734209 | 5g | $237 |
| 4-Methoxy-3-nitropyridine >98.0%(GC) | M2283 | 1g | $84 |
| 4-Methoxy-3-nitropyridine >98.0%(GC) | M2283 | 5g | $244 |
| 4-Methoxy-3-nitropyridine | M3256-35 | 1g | $312 |
| More product size | |||
| Melting point | 74.0 to 78.0 °C |
|---|---|
| Boiling point | 127°C/1mmHg(lit.) |
| Density | 1.300±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 2.51±0.18(Predicted) |
| color | Pale Yellow |
| InChI | 1S/C6H6N2O3/c1-11-6-2-3-7-4-5(6)8(9)10/h2-4H,1H3 |
| InChIKey | BZPVREXVOZITPF-UHFFFAOYSA-N |
| SMILES | COc1ccncc1[N+]([O-])=O |
| CAS DataBase Reference | 31872-62-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36-37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Methoxy-3-nitropyridine price More Price(91)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 734209 | 4-Methoxy-3-nitropyridine 97% | 31872-62-5 | 1g | $64.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 734209 | 4-Methoxy-3-nitropyridine 97% | 31872-62-5 | 5g | $237 | 2022-05-15 | Buy |
| TCI Chemical | M2283 | 4-Methoxy-3-nitropyridine >98.0%(GC) | 31872-62-5 | 1g | $84 | 2025-07-31 | Buy |
| TCI Chemical | M2283 | 4-Methoxy-3-nitropyridine >98.0%(GC) | 31872-62-5 | 5g | $244 | 2025-07-31 | Buy |
| Usbiological | M3256-35 | 4-Methoxy-3-nitropyridine | 31872-62-5 | 1g | $312 | 2026-06-03 | Buy |
4-Methoxy-3-nitropyridine Chemical Properties,Uses,Production
Chemical Properties
Solid
Uses
4-Methoxy-3-nitropyridine is a useful synthetic intermediate.
Synthesis
620-08-6
31872-62-5
The general procedure for the synthesis of 4-methoxy-3-nitropyridine from 4-methoxypyridine was as follows: 4-methoxypyridine (0.5 mL, 4.9 mmol) was slowly added dropwise to concentrated sulfuric acid (5 mL) cooled in an ice bath, and the dropwise time was controlled to be within 20 seconds. Subsequently, fuming nitric acid (5 mL) was added to the reaction mixture and the mixture was heated and reacted at 70 °C for 2.5 days. After completion of the reaction, the mixture was cooled to room temperature and then carefully poured into ice water. The pH of the mixture was adjusted to alkaline with solid potassium carbonate (K2CO3). The mixture was partitioned between water (H2O) and ethyl acetate (EtOAc) to separate the organic and aqueous layers. The aqueous layer was extracted once more with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, and then dried over anhydrous magnesium sulfate (MgSO4). The dried organic phase was filtered and concentrated in vacuum to give a yellow powdery product 4-methoxy-3-nitropyridine 0.7 g in 92% yield. The structure of the product was confirmed by 1H NMR (CDCl3, 300 MHz) and LC-MS: 1H NMR δ 9.02 (s, 1H), 8.65 (d, J = 5.8 Hz, 1H), 7.04 (d, J = 5.9 Hz, 1H), 4.05 (s, 3H); LC-MS m/z 155 (M + 1, 100%), retention time ( Rt) 0.5 min.
References
[1] Patent: WO2011/78984, 2011, A1. Location in patent: Page/Page column 62
4-Methoxy-3-nitropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Nantong Haigine Pharma Technology Co., Ltd | 0086-513-86266699 | CHINA | 156 | 58 |
View Lastest Price from 4-Methoxy-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 4-Methoxy-3-nitropyridine
31872-62-5
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | Methyl 3-nitro-4-pyridinyl ether
31872-62-5
|
$1.00 | 1kg | 95%-99% | Career Henan Chemical Co |
-
- 4-Methoxy-3-nitropyridine
31872-62-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 3-nitro-4-pyridinyl ether
31872-62-5
- $1.00
- 95%-99%
- Career Henan Chemical Co
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