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ChemicalBook >> CAS DataBase List >>Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

CAS No.
106939-34-8
Chemical Name:
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
Synonyms
LEVOFLOXACIN ESTER;7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid;(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester;Ethyl (S)-9;Levofloxacin-13;Ofloxacin Ethyl Ester;3-dihydro-7H-pyrido[1;LEVOFLOXACINCYCLIZEDESTER;Levofloxacin cyclic ester;4-benzoxazine-6-carboxylate
CBNumber:
CB1949760
Molecular Formula:
C15H13F2NO4
Molecular Weight:
309.26
MDL Number:
MFCD09030626
MOL File:
106939-34-8.mol
MSDS File:
SDS
Last updated:2026-05-27 23:54:11
Product description Number Pack Size Price
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester TRC-D445748-5G 5g $491
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester TRC-D445748-500MG 500mg $157
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester TRC-D445748-1G 1g $212
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester FD21854 1kg $900
(S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester FD21854 0.5kg $900
More product size

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Properties

Melting point 258-260°C
Boiling point 442.2±45.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Acetic Acid (Slightly), Chloroform (Slightly), Methanol (Slightly, Heated)
form Solid
pka -3.62±0.60(Predicted)
color Off-White to Light Yellow
InChI InChI=1S/C15H13F2NO4/c1-3-21-15(20)9-5-18-7(2)6-22-14-11(17)10(16)4-8(12(14)18)13(9)19/h4-5,7H,3,6H2,1-2H3/t7-/m0/s1
InChIKey TZSXJUSNOOBBOP-ZETCQYMHSA-N
SMILES O1C2=C(F)C(F)=CC3C(=O)C(C(OCC)=O)=CN(C2=3)[C@@H](C)C1
CAS DataBase Reference 106939-34-8

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
REACH Registrations Active

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D445748-5G (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester 106939-34-8 5g $491 2026-06-03 Buy
TRC TRC-D445748-500MG (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester 106939-34-8 500mg $157 2026-06-03 Buy
TRC TRC-D445748-1G (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester 106939-34-8 1g $212 2026-06-03 Buy
Biosynth FD21854 (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester 106939-34-8 1kg $900 2026-06-04 Buy
Biosynth FD21854 (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester 106939-34-8 0.5kg $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-D445748-5G 5g $491 Buy
TRC-D445748-500MG 500mg $157 Buy
TRC-D445748-1G 1g $212 Buy
FD21854 1kg $900 Buy
FD21854 0.5kg $900 Buy

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Chemical Properties,Uses,Production

Chemical Properties

Off-White Pale Yellow Solid

Uses

Levofloxacin intermediate.

Synthesis

L-Alaninol

2749-11-3

Ethyl acetate

141-78-6

2,3,4,5-Tetrafluorobenzoyl chloride

94695-48-4

Ethyl formate

109-94-4

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate

106939-34-8

Step 1: 2.6 g of sodium hydride (60% dispersed in mineral oil), 50 mL of anhydrous toluene and 8.8 g of ethyl acetate were added sequentially to a dry reaction flask. It was stirred under nitrogen protection until an off-white suspension was formed. Subsequently, 8.8 g of ethyl formate was added slowly and the reaction was stirred at room temperature until complete. Upon completion of the reaction, the mixture was filtered under reduced pressure, the filter cake was collected and washed with anhydrous ether, followed by vacuum drying to give a white solid formyl ethyl acetate sodium salt. Step 2: In another dry reaction flask, 50 mL of anhydrous toluene, 5.5 g of sodium salt of methylacetate and 1.5 g of ZIF-67 ZnCoZIF catalyst were added and mixed well with stirring at room temperature. 7.7 g of 2,3,4,5-tetrafluorobenzoyl chloride was added dropwise slowly, and after the reaction was complete, 3.2 g of S-(+)-2-aminopropanol was added slowly and the reaction was heated to reflux temperature. After the reaction was completed, it was cooled to room temperature, an aqueous layer was added, the aqueous phase was extracted with toluene three times, the organic layers were combined, and the toluene was removed by distillation under reduced pressure to obtain the preliminary product. Step 3: The preliminary product obtained in step 2 was slowly added dropwise to 30 mL of anhydrous DMF solution containing 5.8 g of potassium fluoride, stirred and heated to reflux temperature for azeotropic dehydration. After completion of the reaction, DMF was removed by evaporation under reduced pressure and the residue was washed with water to neutrality to give a brown-yellow viscous solid. After vacuum drying, the intermediate (S)-(-)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid ethyl ester was obtained.

References

[1] Patent: CN108440562, 2018, A. Location in patent: Paragraph 0008; 0010-0015; 0016-0018; 0029

Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Preparation Products And Raw materials

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View Lastest Price from Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate pictures 2026-03-20 Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
106939-34-8
 $10.00 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
LEVOFLOXACIN ACID ESTER pictures 2025-06-20 LEVOFLOXACIN ACID ESTER
106939-34-8
 1kg 99.00% 20tons Hebei Yanxi Chemical Co., Ltd.
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate pictures 2021-11-15 Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate
106939-34-8
 $100.00 100g 99% 500ton/Month Qiuxian Baitai New Material Co., LTD
Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido Levofloxacin cyclization ester (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carbox ethyl (S)-9,10-difluoro-3-methyl-7- oxo-2,3-dihydro-7H- [1,4]oxazino[2,3,4-ij]quinoline-6- carboxylate 7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-, Ethyl Ester, (3s)- Levofloxacin carboxylic acid, ethyl ester LEVOFLOXACINCYCLIZEDESTER (3S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacidethylester ETHYL (S)-9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLATE 7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLIC ACID, 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-, ETHYL ESTER 9,10-Difluoro-3-(S)-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate (S)-Ethyl 9,10-difluoro-3-Methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate (S)-Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxyla Ofloxacin Ethyl Ester ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij]quinoline-6- ethyl carboxylate 10-difluoro-3-methyl-7-oxo-2 3-dihydro-7H-pyrido[1 4-benzoxazine-6-carboxylate Ethyl (S)-9 Levofloxacin-13 Ethyl (S)-9,10-Difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxy LEVOFLOXACIN ACID ESTER USP/EP/BP (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester 7h-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Ethyl Ester Ethyl (3S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate or [levofloxacin acid ester Ethyl (3S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido1,2,3-debenzob1,4oxazine-6-carboxylate Ethyl 8,9-Difluoro-3(S)-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylate ethyl (3S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate (S)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid E Ethyl(S)-9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Levofloxacin cyclic ester LEVOFLOXACIN ESTER Levofloxacin cyclocondensation ester 106939-34-8 C15H13F2NO4 Various Intermediates Intermediates Intermediates & Fine Chemicals Pharmaceuticals LEVOFLOXACIN INTERMIDATE
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