4,4'-Difluorobenzhydrylpiperazine
- CAS No.
- 27469-60-9
- Chemical Name:
- 4,4'-Difluorobenzhydrylpiperazine
- Synonyms
- Flunarizine Impurity A;1-BIS(4-FLUOROPHENYL)METHYL PIPERAZINE;1-Bis(4-fL;1-(4,4'TIMTEC-BB SBB002996;Flunarizine EP Impurity A;1-[Bis(4-Fluorophenyl)methyl]p;4,4-DIFLUOROBENZHYDRYLPIPERAZINE;4,4-Difluorobenzhydrolpiperazine;4,4'-Difluorobenzhydrylpiperazine
- CBNumber:
- CB2161725
- Molecular Formula:
- C17H18F2N2
- Molecular Weight:
- 288.33
- MDL Number:
- MFCD00038660
- MOL File:
- 27469-60-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Bis(4-fluorophenyl)methyl piperazine 97% | 552402 | 5g | $138 |
| 1-Bis(4-fluorophenyl)methyl piperazine >97.0%(GC) | B2764 | 5g | $46 |
| 1-Bis(4-fluorophenyl)methyl piperazine >97.0%(GC) | B2764 | 25g | $154 |
| 1-(4,4'-Difluorobenzhydry)piperazine Asreported | 274294 | 10g | $349 |
| 1-(4,4'-Difluorobenzhydry)piperazine Asreported | 274294 | 25g | $542 |
| More product size | |||
| Melting point | 88-92 °C(lit.) |
|---|---|
| Boiling point | 130 °C |
| Density | 1.1462 (estimate) |
| vapor pressure | 0.001-0.003Pa at 20-25℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol,Toluene |
| pka | 9.00±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to yellow |
| Water Solubility | 0.34 g/L (20 ºC) |
| BRN | 620754 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C17H18F2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2 |
| InChIKey | TTXIFFYPVGWLSE-UHFFFAOYSA-N |
| SMILES | N1(C(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CCNCC1 |
| LogP | 3.3-3.5 at pH7-11 |
| CAS DataBase Reference | 27469-60-9(CAS DataBase Reference) |
| FDA UNII | JT57UD83SY |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 2 Eye Dam. 1 Skin Sens. 1A |
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| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4,4'-Difluorobenzhydrylpiperazine price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 552402 | 1-Bis(4-fluorophenyl)methyl piperazine 97% | 27469-60-9 | 5g | $138 | 2023-06-20 | Buy |
| TCI Chemical | B2764 | 1-Bis(4-fluorophenyl)methyl piperazine >97.0%(GC) | 27469-60-9 | 5g | $46 | 2026-04-30 | Buy |
| TCI Chemical | B2764 | 1-Bis(4-fluorophenyl)methyl piperazine >97.0%(GC) | 27469-60-9 | 25g | $154 | 2026-04-30 | Buy |
| Usbiological | 274294 | 1-(4,4'-Difluorobenzhydry)piperazine Asreported | 27469-60-9 | 10g | $349 | 2026-06-03 | Buy |
| Usbiological | 274294 | 1-(4,4'-Difluorobenzhydry)piperazine Asreported | 27469-60-9 | 25g | $542 | 2026-06-03 | Buy |
4,4'-Difluorobenzhydrylpiperazine Chemical Properties,Uses,Production
Chemical Properties
white to yellow crystalline powder
Uses
1-Bis(4-fluorophenyl)methyl piperazine may be used to synthesize 1-[bis(4-fluorophenyl)methyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine and (R, S) 3-[4-(bis(4-fluorophenyl)methyl)piperazin-1-yl]dihydrofuran-2(3H)-one.
General Description
1-Bis(4-fluorophenyl)methyl piperazine is formed during the synthesis of flunarizine. Its crystals exhibits monoclinic crystal system and space group P21/c.
Synthesis
110-85-0
27064-94-4
27469-60-9
GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of benzophenone (1.0 mol) in methanol (2 vol) for 45 min at room temperature. The reaction mixture was stirred at ambient temperature for 2-3 h (the progress of the reaction was monitored by TLC), followed by dilution with water (750 mL) and adjusting the pH with acetic acid to 4. Extraction was carried out with dichloromethane (2 x 400 mL), the organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to afford the pure benzophenol derivative as a white to off-white solid The yield was 93-97%. To a solution of diphenylmethanol derivative (1.0 mol) in toluene (370 mL) at room temperature, concentrated HCl (35% aqueous solution, 370 mL) and tetrabutylammonium bromide (0.01 mol) were added while stirring. The mixture was stirred continuously at 40-45 °C for 6-7 hours. After completion of the reaction (confirmed by TLC), it was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give the crude diphenylmethyl chloride derivative as a light brown liquid in 95-97% yield. To a solution of diphenylmethyl chloride derivative (0.96 mol) in toluene (380 mL) at 60-70°C, anhydrous piperazine (5.0 mol) was slowly added over 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction, the mixture was cooled, water (380 mL) was added and the organic layer was separated. The organic layer was washed with a mixture of concentrated HCl and water (1:1, 2 x 350 mL) and neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2 × 300 mL), and the organic layer was dried with anhydrous sodium sulfate and concentrated in vacuum to give pure 1-(bis(p-fluorophenyl)methyl)piperazine as a white to off-white solid in 88% yield.
References
[1] Journal of Medicinal Chemistry, 1997, vol. 40, # 13, p. 2047 - 2052
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1822 - 1826
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, vol. 29, # 2, p. 205 - 214
[5] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609
4,4'-Difluorobenzhydrylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Moxin Chemicals | +86-17320513646 +86-17320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8618017249410 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
View Lastest Price from 4,4'-Difluorobenzhydrylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-16 | Flunarizine EP Impurity A
27469-60-9
|
10mg | 95%+ | 100000 | Moxin Chemicals | ||
 |
2025-06-20 | 4,4'-Difluorobenzhydrylpiperazine
27469-60-9
|
1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | ||
 |
2020-01-03 | 4,4'-Difluorobenzhydrylpiperazine
27469-60-9
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- Flunarizine EP Impurity A
27469-60-9
- 95%+
- Moxin Chemicals
-
- 4,4'-Difluorobenzhydrylpiperazine
27469-60-9
- $0.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 4,4'-Difluorobenzhydrylpiperazine
27469-60-9
- $1.00
- 99%
- Career Henan Chemical Co
