tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
- CAS No.
- 1207175-73-2
- Chemical Name:
- tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
- Synonyms
- 2-(Boc-amino)-5-bromo-3-hydroxypyridine;tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate;tert-butyl N-(5-bromo-3-hydroxy-2-pyridyl)carbamate;ert-butylN-(5-bromo-3-hydroxypyridin-2-yl)carbamate;Tert butyl 5-bromo-3-hydroxypyridin-2-ylaminoformate;tert-butyl N-(5-bromo-3-hydroxypyridin-2-yl)carbamate;Carbamic acid, N-(5-bromo-3-hydroxy-2-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB22470379
- Molecular Formula:
- C10H13BrN2O3
- Molecular Weight:
- 289.13
- MDL Number:
- MFCD12756114
- MOL File:
- 1207175-73-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | B52894 | 100mg | $130 |
| tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | B52894 | 250mg | $144 |
| tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | B52894 | 1g | $147 |
| tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | B52894 | 5g | $150 |
| tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | B52894 | 10g | $250 |
| Boiling point | 363.8±42.0 °C(Predicted) |
|---|---|
| Density | 1.552 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 8.02±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| InChI | InChI=1S/C10H13BrN2O3/c1-10(2,3)16-9(15)13-8-7(14)4-6(11)5-12-8/h4-5,14H,1-3H3,(H,12,13,15) |
| InChIKey | FKSQRZXAISFJAG-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=NC=C(Br)C=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B52894 | tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | 1207175-73-2 | 100mg | $130 | 2026-05-06 | Buy |
| Synthonix | B52894 | tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | 1207175-73-2 | 250mg | $144 | 2026-05-06 | Buy |
| Synthonix | B52894 | tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | 1207175-73-2 | 1g | $147 | 2026-05-06 | Buy |
| Synthonix | B52894 | tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | 1207175-73-2 | 5g | $150 | 2026-05-06 | Buy |
| Synthonix | B52894 | tert-Butyl (5-bromo-3-hydroxypyridin-2-yl)carbamate 97% | 1207175-73-2 | 10g | $250 | 2026-05-06 | Buy |
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Chemical Properties,Uses,Production
Synthesis
24424-99-5
39903-01-0
1207175-73-2
Example 1 Synthesis of 5-bromo-3-hydroxy-2-tert-butoxycarbonylaminopyridine (0038): 2-amino-3-hydroxy-5-bromopyridine (10.0 g, 53.0 mmol) and triethylamine (10 mL, 71.8 mmol) were added to dichloromethane (100 mL) followed by di-tert-butyl dicarbonate (12.7 g, 58.4 mmol). The reaction mixture was stirred at room temperature for 18 hours. Water (150 mL) was added and stirring was continued for 30 minutes. The reaction mixture was filtered through diatomaceous earth to separate the organic layer. The aqueous layer was extracted with dichloromethane (150 mL). The combined organic layers were washed with saturated aqueous sodium chloride (2 x 100 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with hexane (100 mL), filtered and dried in vacuum to give 5-bromo-3-hydroxy-2-tert-butoxycarbonylaminopyridine (15.0 g, 98.0% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 2.0 Hz, 1H), 7.58 (d, J = 2.0 Hz, 1H), 4.67 (br s, 2H), 1.56 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 150.4, 150.1, 145.3, 133.5, 131.3 133.5, 131.5, 106.5, 85.0, 27.6.
References
[1] Patent: US2015/307476, 2015, A1. Location in patent: Paragraph 0038-0039
[2] Tetrahedron Letters, 2014, vol. 55, # 9, p. 1528 - 1531
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25356 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43333 | 58 |
| Qingdao Dexin Chemical Co., Ltd | +86-15553333686 | 15553333686@qq.com | China | 3113 | 58 |
| ANHUI BYERSEN BIOTECH CO. LTD | +86-15385096007 +86-17755058861 | amy@byersenchemical.com | China | 10000 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18934348241 | sales4.gd@hwrkchemical.com | China | 14063 | 55 |
View Lastest Price from tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
1207175-73-2
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
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- tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
1207175-73-2
- $9.80
- ≥99%
- Career Henan Chemical Co
