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ChemicalBook >> CAS DataBase List >>2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

CAS No.
60832-72-6
Chemical Name:
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
Synonyms
oxazolo[4,5-b]pyridin-2(3H)-one;(1,3 )oxazolo( 4,5-b) pyridin-2(3H)-one;Oxazolophridinon;2,3-Dihydropyrido[2;Oxazolo[4,5-b]pyridin-2-ol;Crizotinib Intermediates 3;3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE;[1,3]Oxazolo[4,5-b]pyridin-2-ol;Oxazolo[4,5-b]pyridine-2(3H)one;oxazolo[4,5-6]pyridine-2(3h)-one
CBNumber:
CB0114606
Molecular Formula:
C6H4N2O2
Molecular Weight:
136.11
MDL Number:
MFCD00204215
MOL File:
60832-72-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:05:17
Product description Number Pack Size Price
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one AldrichCPR CDS005683 100MG $68.1
Oxazolo[4,5-b]pyridin-2(3H)-one O0408 5G $63
Oxazolo[4,5-b]pyridin-2(3H)-one O0408 25G $191
3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 97% 37400 5G $17
3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 97% 37400 25G $23
More product size

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Properties

Melting point 214 °C
Boiling point 253.8±23.0 °C(Predicted)
Density 1.59±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka 2.76±0.20(Predicted)
form Solid
color Tan
InChI InChI=1S/C6H4N2O2/c9-6-8-5-4(10-6)2-1-3-7-5/h1-3H,(H,7,8,9)
InChIKey OVLXOTUWFLHWQT-UHFFFAOYSA-N
SMILES C12NC(=O)OC1=CC=CN=2
CAS DataBase Reference 60832-72-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-36-22
Safety Statements  22-26-36/37/39
Hazard Note  Harmful
HS Code  2934999090
REACH Registrations Active

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS005683 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one AldrichCPR 60832-72-6 100MG $68.1 2023-01-07 Buy
TCI Chemical O0408 Oxazolo[4,5-b]pyridin-2(3H)-one 60832-72-6 5G $63 2026-04-30 Buy
TCI Chemical O0408 Oxazolo[4,5-b]pyridin-2(3H)-one 60832-72-6 25G $191 2026-04-30 Buy
AstaTech 37400 3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 97% 60832-72-6 5G $17 2026-04-30 Buy
AstaTech 37400 3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 97% 60832-72-6 25G $23 2026-04-30 Buy
Product number Packaging Price Buy
CDS005683 100MG $68.1 Buy
O0408 5G $63 Buy
O0408 25G $191 Buy
37400 5G $17 Buy
37400 25G $23 Buy

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one is a benzoxazolone analogue that may be used to inhibit the nitric oxide synthases (NOS).

Definition

ChEBI: Oxazolo[4,5-b]pyridin-2(3H)-one is a lactone. It derives from a hydride of an oxazolo[4,5-b]pyridine.

Synthesis

2-Amino-3-hydroxypyridine

16867-03-1

1,1'-Carbonyldiimidazole

530-62-1

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one

60832-72-6

N,N'-Carbonyldiimidazole (57.4 g, 354.2 mmol) was slowly added to a tetrahydrofuran (THF) solution (400 mL) of 2-amino-3-hydroxypyridine (26.0 g, 236.1 mmol, purchased from Aldrich) as described in Step 4-i of Scheme 4. The resulting reaction mixture was stirred at 70 °C for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The concentrated residue was dissolved in dichloromethane (DCM) (500 mL) and subsequently washed with 2N sodium hydroxide (NaOH) solution (3 x 100 mL). The aqueous phases were combined, cooled to 0 °C, and the pH was adjusted to 6 with 6 N hydrochloric acid (HCl).At this point, the product precipitated as a precipitate, which was collected through a sintered funnel and washed with cold water (100 mL). Finally, the product was dried under vacuum to afford 2,3-dihydropyrido[2,3-d][1,3]oxazol-2-one (compound 1011, 26.0 g, 81% yield). The product was characterized by the following data: electrospray mass spectrometry (ESMS) (M + H) + m/z 137; 1H NMR (DMSO-d6) δ 12.4 (br, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 7.1 (dd, 1H).

References

[1] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 56; 91
[2] Patent: WO2010/96389, 2010, A1. Location in patent: Page/Page column 42; 44
[3] Patent: WO2010/135014, 2010, A1. Location in patent: Page/Page column 50-51
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 8066 - 8096
[5] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 120

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View Lastest Price from 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one pictures 2026-03-20 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
60832-72-6
 $10.00 100KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one pictures 2025-06-27 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
60832-72-6
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one pictures 2025-06-20 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one
60832-72-6
 $10.00-50.00 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one Spectrum

2,3-Dihydropyrido[2 2,3-Dihydropyrido[2,3-d]oxazol-2-one 2H,3H-[1,3]oxazolo[4,5-b]pyridin-2-one (1,3) OXAZOLO (4,5-B) PYRIDINE-2(3H)-ONE 3H-OXAZOLO[4,5-B]PYRIDIN-2-ONE 2,3-DIHYDROPYRIDO[2,3-D][1,3]OXAZOL-2-ONE [1,3]Oxazolo[4,5-b]pyridin-2-ol oxazolo[4,5-6]pyridine-2(3h)-one Oxazolo[4,5-b]pyridine-2(3H)one Oxazolophridinon 2,3-Dihydropyrido[2,3-d]oxazol-2-one,97% 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one ISO 9001：2015 REACH 2,3-dihydro[1,3]oxazolo[4,5-b]pyridin-2-one Oxazolo[4,5-b]pyridin-2-ol Crizotinib Intermediates 3 Oxazolo[4,5-b]pyridin-2(3H)-one (9CI, ACI) 3H-Oxazolo[4,5-b]pyridin-2(3H)-one 3H-Oxazolo[4,5-b]pyridin-2-one (100gx1,25gx3, 10gx5, 5gx6, 3.7gx1) 2.3-Dihydropyrido[2,3-d][1,3]oxazo1-2-one 3H-[1,3]oxazolo[4,5-b]pyridin-2-one 3H-azolebenzo[4,5-b]pyridine-2-one (1,3 )oxazolo( 4,5-b) pyridin-2(3H)-one oxazolo[4,5-b]pyridin-2(3H)-one 60832-72-6 Aromatics Heterocycles
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