GW806742X
- CAS No.
- 579515-63-2
- Chemical Name:
- GW806742X
- Synonyms
- CS-2659;GW806742X;GW806742X ≥95%;GW806742X >=98% (HPLC);GW806742X, 10 mM in DMSO;GW806742X;GW-806742X;GW 806742X;1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea;3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide;3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide;Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-
- CBNumber:
- CB23067556
- Molecular Formula:
- C25H22F3N7O4S
- Molecular Weight:
- 573.55
- MDL Number:
- MFCD29036385
- MOL File:
- 579515-63-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GW806742X ≥98% (HPLC) | SML1990 | 5MG | $152 |
| GW806742X ≥98% (HPLC) | SML1990 | 25MG | $584 |
| GW 806742X ≥98% | 37541 | 5mg | $61 |
| GW 806742X ≥98% | 37541 | 10mg | $115 |
| GW 806742X ≥98% | 37541 | 25mg | $269 |
| More product size | |||
| Density | 1.524±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM) |
| pka | 10.09±0.60(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | SNRUTMWCDZHKKM-UHFFFAOYSA-N |
| SMILES | CN(C1=NC(NC2=CC(S(=O)(N)=O)=CC=C2)=NC=C1)C3=CC=C(NC(NC4=CC=C(OC(F)(F)F)C=C4)=O)C=C3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
GW806742X price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1990 | GW806742X ≥98% (HPLC) | 579515-63-2 | 5MG | $152 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1990 | GW806742X ≥98% (HPLC) | 579515-63-2 | 25MG | $584 | 2026-04-30 | Buy |
| Cayman Chemical | 37541 | GW 806742X ≥98% | 579515-63-2 | 5mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 37541 | GW 806742X ≥98% | 579515-63-2 | 10mg | $115 | 2026-04-30 | Buy |
| Cayman Chemical | 37541 | GW 806742X ≥98% | 579515-63-2 | 25mg | $269 | 2026-04-30 | Buy |
GW806742X Chemical Properties,Uses,Production
Uses
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2].
Biological Activity
GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis.
in vitro
GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
target
| MLKL 9.3 μM (Kd) | VEGFR2 2 nM (IC 50 < /sub> ) |
IC 50
MLKL: 9.3 μM (Kd); VEGFR2: 2 nM (IC50)
References
[1] Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. DOI:10.1073/pnas.1408987111
[2] Sammond DM, et al. Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase. Bioorg Med Chem Lett. 2005;15(15):3519-3523. DOI:10.1016/j.bmcl.2005.05.096
GW806742X Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +86-18051384581 | sales@chemhifuture.com | China | 3123 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9937 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3999 | 55 |
