4,6-Dichloro-5-methoxypyrimidine
- CAS No.
- 5018-38-2
- Chemical Name:
- 4,6-Dichloro-5-methoxypyrimidine
- Synonyms
- 2,4-dimethoxy-2-methylmercapyrimidine;6-Dichloro-5-MethoxypyriMidine;4,6-Dichlor-5-methoxypyrimidin;5-methox-4,6-Dichloropyrimidin;4,6-Dichloro-5-methypyrimidine;2,4-Dichloro-5-MetoxyPyriMidine;4,6-DICHLORO-5-METHOXYPYRIMIDINE;5-Methoxy-4,6-dichloropyriMidine;4,6-Dichloro-5-methoxy-1,3-diazine;4,6 -Dicholoro-5 Methoxy Pyrimidine
- CBNumber:
- CB2390639
- Molecular Formula:
- C5H4Cl2N2O
- Molecular Weight:
- 179
- MDL Number:
- MFCD00087680
- MOL File:
- 5018-38-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,6-Dichloro-5-methoxypyrimidine 97% | 706485 | 1g | $80.9 |
| 4,6-Dichloro-5-methoxypyrimidine >98.0%(GC) | D4723 | 5g | $26 |
| 4,6-Dichloro-5-methoxypyrimidine >98.0%(GC) | D4723 | 25g | $83 |
| 4,6-Dichloro-5-methoxypyrimidine Asreported | 295951 | 5g | $345 |
| 4,6-Dichloro-5-methoxypyrimidine Asreported | 295951 | 10g | $473 |
| More product size | |||
| Melting point | 54-58 °C |
|---|---|
| Boiling point | 257.8±35.0 °C(Predicted) |
| Density | 1.446±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly) |
| form | Solid |
| pka | -4.13±0.26(Predicted) |
| color | White |
| InChI | InChI=1S/C5H4Cl2N2O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3 |
| InChIKey | IJQIGKLDBGKSNT-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=C(OC)C(Cl)=N1 |
| CAS DataBase Reference | 5018-38-2(CAS DataBase Reference) |
| FDA UNII | LT6L8EYV2M |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933599590 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 |
|||||||||
| NFPA 704 |
|
4,6-Dichloro-5-methoxypyrimidine price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 706485 | 4,6-Dichloro-5-methoxypyrimidine 97% | 5018-38-2 | 1g | $80.9 | 2023-06-20 | Buy |
| TCI Chemical | D4723 | 4,6-Dichloro-5-methoxypyrimidine >98.0%(GC) | 5018-38-2 | 5g | $26 | 2026-04-30 | Buy |
| TCI Chemical | D4723 | 4,6-Dichloro-5-methoxypyrimidine >98.0%(GC) | 5018-38-2 | 25g | $83 | 2026-04-30 | Buy |
| Usbiological | 295951 | 4,6-Dichloro-5-methoxypyrimidine Asreported | 5018-38-2 | 5g | $345 | 2026-06-03 | Buy |
| Usbiological | 295951 | 4,6-Dichloro-5-methoxypyrimidine Asreported | 5018-38-2 | 10g | $473 | 2026-06-03 | Buy |
4,6-Dichloro-5-methoxypyrimidine Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Uses
4,6-Dichloro-5-methoxypyrimidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
5193-84-0
5018-38-2
Example 3.2 Preparation of 4,6-dichloro-5-methoxypyrimidine: 5-methoxypyrimidine-4,6-diol (96.0 g, 676 mmol) and triethylamine (95.0 mL, 680 mmol) were suspended in anhydrous toluene (1.2 L) and heated to 100-105°C. A solution of anhydrous toluene (200 mL) with trichlorophosphate (140 mL, 1.5 mol) was added slowly and dropwise over 30 min. The reaction mixture was refluxed for 1 hour and cooled to room temperature. The toluene layer was decanted and ice water was added to the residue. The heavier black oil layer was separated, dilution was continued with ice water, and the mixture was extracted with toluene (2 x 200 mL). The toluene extracts were combined and the aqueous layer discarded. The organic phase was washed sequentially with saturated sodium bicarbonate solution (2×300 mL), saturated saline (400 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the title compound 4,6-dichloro-5-methoxypyrimidine (103.4 g, 86% yield) as a white solid.1H NMR (CDCl3) δ 4.00 (s, 3H), 8.55 (s, 1H).
References
[1] Patent: US2009/286816, 2009, A1. Location in patent: Page/Page column 12
[2] Patent: EP714896, 1996, A1
[3] Patent: US2006/52398, 2006, A1. Location in patent: Page/Page column 39
[4] Patent: US5300506, 1994, A
[5] Patent: US5077293, 1991, A
4,6-Dichloro-5-methoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Guiren Medicine Co.,Ltd | +86-13815020719 | guiren_medicine@163.com | China | 212 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +86-18958038633; +86-18958038633 | tony@sdhypharma.com | China | 64 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-17392712779 | 1097@dideu.com | China | 3992 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
View Lastest Price from 4,6-Dichloro-5-methoxypyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-24 | 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
|
1KG | 99.0% | 1000Tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4,6-Dichloro-5-methoxypyrimidine
5018-38-2
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
