alpha-Angelica lactone
- CAS No.
- 591-12-8
- Chemical Name:
- alpha-Angelica lactone
- Synonyms
- 2(3H)-Furanone, 5-methyl-;5-METHYL-2(3H)-FURANONE;α-Angelica lactone;5-Methylfuran-2(3H)-one;FEMA 3293;ANGELICALACTONE;3-PENTEN-4-OLIDE;alpha-Angelica lactone 98%;4-HYDROXY-3-PENTENOIC ACID GAMMA-LACTONE;A-ANGELICALACTONE
- CBNumber:
- CB2760151
- Molecular Formula:
- C5H6O2
- Molecular Weight:
- 98.1
- MDL Number:
- MFCD00005375
- MOL File:
- 591-12-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| α-Angelica lactone natural (US), ≥90%, sum of isomers | W329355 | 1 each | $66 |
| α-Angelica lactone natural (US), ≥90%, sum of isomers | W329355 | 100 g | $251 |
| α-Angelica lactone 98%, FG | W329304 | 1 each | $51.4 |
| α-Angelica lactone natural (US), ≥90%, sum of isomers | W329355 | 500 g | $764 |
| α-Angelica lactone 98%, FG | W329304 | 100g | $169 |
| More product size | |||
| Melting point | 13-17 °C(lit.) |
|---|---|
| Boiling point | 55-56 °C12 mm Hg(lit.) |
| Density | 1.092 g/mL at 25 °C(lit.) |
| refractive index |
n |
| FEMA | 3293 | 4-HYDROXY-3-PENTENOIC ACID LACTONE |
| FLAVIS Number | 10.012 | 5-Methylfuran-2(3H)-one |
| Flash point | 155 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate |
| form | Oil |
| pka | pK1:4.3 (25°C) |
| Specific Gravity | 1.101.092 |
| color | Clear Light Yellow |
| Odor | at 10.00 % in dipropylene glycol. sweet solvent nutty tonka coumarin tobacco |
| Odor Type | coconut |
| biological source | synthetic |
| Water Solubility | 5 g/100 mL (25 ºC) |
| Merck | 14,647 |
| JECFA Number | 221 |
| BRN | 108394 |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C5H6O2/c1-4-2-3-5(6)7-4/h2H,3H2,1H3 |
| InChIKey | QOTQFLOTGBBMEX-UHFFFAOYSA-N |
| SMILES | CC1=CCC(=O)O1 |
| LogP | 0.84 |
| CAS DataBase Reference | 591-12-8(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 4-HYDROXY-3-PENTENOIC ACID LACTONE |
| FDA UNII | 29CRF6L9C5 |
| NIST Chemistry Reference | 2(3H)-Furanone, 5-methyl-(591-12-8) |
| EPA Substance Registry System | 5-Methyl-2(3H)-furanone (591-12-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H227 | |||||||||
| Precautionary statements | P210-P280-P403+P235-P501-P210e-P280a-P370+P378a-P501a | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | LU5075000 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Skin Sens. 1 | |||||||||
| Toxicity | LD50 orl-mus: 2800 mg/kg DCTODJ 3,249,80 | |||||||||
| NFPA 704 |
|
alpha-Angelica lactone price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W329355 | α-Angelica lactone natural (US), ≥90%, sum of isomers | 591-12-8 | 1 each | $66 | 2026-04-30 | Buy |
| Sigma-Aldrich | W329355 | α-Angelica lactone natural (US), ≥90%, sum of isomers | 591-12-8 | 100 g | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | W329304 | α-Angelica lactone 98%, FG | 591-12-8 | 1 each | $51.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | W329355 | α-Angelica lactone natural (US), ≥90%, sum of isomers | 591-12-8 | 500 g | $764 | 2026-04-30 | Buy |
| Sigma-Aldrich | W329304 | α-Angelica lactone 98%, FG | 591-12-8 | 100g | $169 | 2026-04-30 | Buy |
alpha-Angelica lactone Chemical Properties,Uses,Production
Chemical Properties
α-Angelica lactone has a sweet, herbaceous odor reminiscent of tobacco.
Chemical Properties
clear colorless to straw yellow liquid
Occurrence
Reported found in grape, white bread, soy bean and licorice.
Uses
alpha-Angelicalactone acts as acancer chemopreventive agent. It is used in the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver. It is used in oral care formulations to round out mint notes and in coffee flavors.
Preparation
By dry distillation of levulinic acid
Application
alpha-Angelica lactone finds occasional use in the reconstitution of essential oils. lts intensely sweet-herbaceous, almost tobacco-like odor makes this chemical interesting for application in new fragrance types. However, it would be wise to investigate its pharmacological and dermatological properties first.
Definition
ChEBI: Alpha-angelica lactone is an angelica lactone and a butenolide. It is functionally related to a but-3-en-4-olide. It is a tautomer of a beta-angelica lactone.
Taste threshold values
Taste characteristics at 100 ppm: sweet, creamy, coconut, vanilla hay and coumarin-like nuances
General Description
α-Angelica lactone, a cyclic lactone that occurs naturally in tobacco, is generally used in tobacco flavoring.
Biochem/physiol Actions
Plant-derived cancer chemopreventive agent. Increases the synthesis of glutathione and the activity of glutathione-S-transferase and UDP-glucunonosyltransferase detoxification enzymes in esophagus, stomach, intestine, and liver.
Safety Profile
Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits acrid smoke and irritating fumes.
alpha-Angelica lactone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from alpha-Angelica lactone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | α-Angelica lactone
591-12-8
|
$29.00 | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | alpha-Angelica lactone
591-12-8
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | alpha-Angelica lactone
591-12-8
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- α-Angelica lactone
591-12-8
- $29.00
- 99.79%
- TargetMol Chemicals Inc.
-
- alpha-Angelica lactone
591-12-8
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- alpha-Angelica lactone
591-12-8
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
