ChemicalBook >> CAS DataBase List >>(R)-1-Boc-3-Hydroxypiperidine
(R)-1-Boc-3-Hydroxypiperidine
- CAS No.
- 143900-43-0
- Chemical Name:
- (R)-1-Boc-3-Hydroxypiperidine
- Synonyms
- tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate;(R)-1-N-BOC-3-HYDROXYPIPERIDINE;Ibrutinib INT2;Peridine Impurity 2;(R)-1-BOC-3-PIPERIDINOL;(R)-N-BOC-3-HYDROXYPIPERIDINE;(R)-1-BOC-3-HYDROXYPIPERIDINE;(R)-1-Boc-3-hydroxypiperidine 95%;(R)-1-Boc-3-hydroxypiperidine,97%;(R)-1-Boc-3-hydroxypiperidine
- CBNumber:
- CB3125016
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD04115306
- MOL File:
- 143900-43-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-06-04 16:00:12
| Product description | Number | Pack Size | Price |
| (R)-1-Boc-3-hydroxypiperidine 95% | 687278 | 1g | $118 |
| (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | B4199 | 1g | $26 |
| (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | B4199 | 5g | $80 |
| (R)-1-Boc-3-hydroxypiperidine Asreported | 264565 | 500mg | $305 |
| (R)-1-Boc-3-hydroxypiperidine Asreported | 264565 | 1g | $403 |
| More product size | |||
| Melting point | 43-50 °C |
|---|---|
| Boiling point | 292.3±33.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Flash point | 104°C |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | Low Melting Solid |
| pka | 14.74±0.20(Predicted) |
| color | White to tan |
| optical activity | [α]/D 22±3°, c = 5 in methanol |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1 |
| InChIKey | UIJXHKXIOCDSEB-MRVPVSSYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@@H](O)C1 |
| CAS DataBase Reference | 143900-43-0(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 36/37/38-41-37/38-25 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
(R)-1-Boc-3-Hydroxypiperidine price More Price(103)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 687278 | (R)-1-Boc-3-hydroxypiperidine 95% | 143900-43-0 | 1g | $118 | 2026-04-30 | Buy |
| TCI Chemical | B4199 | (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-43-0 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | B4199 | (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-43-0 | 5g | $80 | 2026-04-30 | Buy |
| Usbiological | 264565 | (R)-1-Boc-3-hydroxypiperidine Asreported | 143900-43-0 | 500mg | $305 | 2026-06-03 | Buy |
| Usbiological | 264565 | (R)-1-Boc-3-hydroxypiperidine Asreported | 143900-43-0 | 1g | $403 | 2026-06-03 | Buy |
(R)-1-Boc-3-Hydroxypiperidine Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. It has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.
Synthesis
A suspension of (3R)-piperidin-3-ol hydrochloride (3.17 g, 0.023 mol) in CH2Cl2 (40 mL) was treated with Na2CO3 (5.13 g, 0) dissolved in H2O (80 mL) 0.048 mol) and then treated with diiron dicarbonate/fluorobutyl ester (5.53 g, 0.025 mol) and additional CH2Cl3 (24 mL). The resulting mixture was stirred for 21 hours. The layers were separated and the aqueous phase was extracted with CH2Cl2 (3x50) mL) to extract the aqueous phase. The combined organic layers were dried with Na2SO4, filtered, and concentrated in vacuo. The residue was analyzed by column chromatography (9:1 CH2Cl2:MeOH) purification to give colorless oily (R)-1-Boc-3-hydroxypiperidine (5.07 g, quantitative). Mass spectrum (M+1): 202.0. 1H NMR (400 MHz, chloroform-D) ppm of 1.40-1.56 (M, 2h), 1.44 (s, 9h), 1.67-1.80 (M, 1H), 1.80-1.93 (M, 1 H), 2.95-3.22 (M, 2h), 3.47 (D, J=5.1 Hz, 1H), 3.51 (brs, 1H) and 3.64-3.78 (M, 2 H).
(R)-1-Boc-3-Hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 309)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8741 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
View Lastest Price from (R)-1-Boc-3-Hydroxypiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-04 | (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
|
$63.00-308.00 | 100g | 0.99 | 25kg | Shanghai UCHEM Inc. | |
 |
2025-11-18 | (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
- $63.00-308.00
- 0.99
- Shanghai UCHEM Inc.
-
- (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- (R)-1-Boc-3-Hydroxypiperidine
143900-43-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
143900-43-0((R)-1-Boc-3-Hydroxypiperidine)Related Search:
(R)-1-Boc-3-hydroxypiperidine 95%
tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
tert- butyl (R)-3-hydroxy piperidine-1-carboxylate
(R)-1-Boc-3-hydroxypiperidine,97%
(R)-1-BOC-3-PIPERIDINOL
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(r)-3-hydroxy-piperidine-1-carboxylic acid tert-but
(R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >
(R)-1-Boc-3-Hydroxypiperidine ISO 9001：2015 REACH
(R)-1-N-BOC-3-HYDROXYPIPERIDINE
1,1-Dimethylethyl (3R)-3-hydroxy-1-piperidinecarboxylate
143900-43-0
tert-Butyl (3R)-3-hydroxy-1-piperidinecarboxylate
Peridine Impurity 2
(R)-1-Boc-3-hydroxypiperidine
tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate
143900-43-0
143900-43-00
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