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2-Chloro-5-fluoronicotinonitrile

2-Chloro-5-fluoronicotinonitrile structure

CAS No.: 791644-48-9

Chemical Name:: 2-Chloro-5-fluoronicotinonitrile

Synonyms: 2-Chloro-5-fluoropyridine-3-carbonitrile;2-Chloro-5-fluoronicotinonitrile;2-Chloro-5-fluoro-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-chloro-5-fluoro-;2-Chloro-5-fluoronicotinonitrile ISO 9001：2015 REACH

CBNumber:: CB32516238

Molecular Formula:: C6H2ClFN2

Molecular Weight:: 156.54

MDL Number:: MFCD15526908

MOL File:: 791644-48-9.mol

MSDS File:: SDS

Last updated:2026-07-25 07:39:42

Product description	Number	Pack Size	Price
2-Chloro-3-cyano-5-fluoro pyridine Asreported	269046	500mg	$460
2-Chloro-3-cyano-5-fluoro pyridine Asreported	269046	1g	$772
2-Chloro-3-cyano-5-fluoro pyridine Asreported	269046	2g	$1097
2-Chloro-3-cyano-5-fluoro pyridine Asreported	269046	5g	$1805
2-Chloro-3-cyano-5-fluoro pyridine Asreported	269046	10g	$2654
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2-Chloro-5-fluoronicotinonitrile Properties

Boiling point	235℃
Density	1.43
Flash point	96℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-4.51±0.10(Predicted)
form	solid
color	White to off-white
InChI	InChI=1S/C6H2ClFN2/c7-6-4(2-9)1-5(8)3-10-6/h1,3H
InChIKey	SUBZTZVHVGYOPM-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(F)C=C1C#N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
HS Code	2933399990

2-Chloro-5-fluoronicotinonitrile price More Price(80)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	269046	2-Chloro-3-cyano-5-fluoro pyridine Asreported	791644-48-9	500mg	$460	2026-06-03	Buy
Usbiological	269046	2-Chloro-3-cyano-5-fluoro pyridine Asreported	791644-48-9	1g	$772	2026-06-03	Buy
Usbiological	269046	2-Chloro-3-cyano-5-fluoro pyridine Asreported	791644-48-9	2g	$1097	2026-06-03	Buy
Usbiological	269046	2-Chloro-3-cyano-5-fluoro pyridine Asreported	791644-48-9	5g	$1805	2026-06-03	Buy
Usbiological	269046	2-Chloro-3-cyano-5-fluoro pyridine Asreported	791644-48-9	10g	$2654	2026-06-03	Buy

Product number	Packaging	Price	Buy
269046	500mg	$460	Buy
269046	1g	$772	Buy
269046	2g	$1097	Buy
269046	5g	$1805	Buy
269046	10g	$2654	Buy

2-Chloro-5-fluoronicotinonitrile Chemical Properties,Uses,Production

Synthesis

75302-64-6

791644-48-9

Example 3A: Synthesis of 2-chloro-5-fluoronicotinonitrile 81.2 mL (582.25 mmol) of triethylamine was added to a 783 mL dichloromethane suspension containing 46.2 g (264.66 mmol) of 2-chloro-5-fluoronicotinonitrile, and the mixture was subsequently cooled to 0°C. Under continuous stirring, 41.12 mL (291.13 mmol) of trifluoroacetic anhydride was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was kept at 0 °C with continued stirring for 1.5 hours. After completion of the reaction, the reaction mixture was washed twice with saturated aqueous sodium bicarbonate (391 mL each time), and the organic phase was dried and concentrated under reduced pressure to give the crude product. The final product was 2-chloro-5-fluoronicotinonitrile with a yield of 42.1 g and 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 8.66 (dd, 1H), 8.82 (d, 1H).

References

[1] Patent: WO2013/25958, 2013, A1. Location in patent: Page/Page column 57; 58
[2] Patent: TWI609011, 2017, B. Location in patent: Page/Page column 77; 78
[3] Patent: EP2680844, 2016, B1. Location in patent: Paragraph 0134
[4] Patent: EP2744501, 2016, B1. Location in patent: Paragraph 0164; 0166
[5] Patent: TW2018/8946, 2018, A. Location in patent: Page/Page column 67

2-Chloro-5-fluoronicotinonitrile synthesis

Synthesis of 2-Chloro-5-fluoronicotinonitrile from 2-CHLORO-5-FLUORO-PYRIDINE-3-CARBALDEHYDE

2-Chloro-5-fluoronicotinonitrile Preparation Products And Raw materials

Raw materials

2,4-Pentadienoic acid, 2-cyano-5-(dimethylamino)-4-fluoro-, ethyl ester, (2E,4Z)- 2-CHLORO-5-FLUORO-3-PYRIDINECARBONYL CHLORIDE 2-Chloro-5-fluoronicotinic acid 2-chloro-5-fluoronicotinaMide 2,6-Dichloro-5-fluoronicotinic acid

2-CHLORO-5-FLUORO-3-IODOPYRIDINE Ethyl 2-chloro-5-fluoronicotinate 2-CHLORO-5-FLUORO-PYRIDINE-3-CARBALDEHYDE 2,6-Dichloro-5-fluoronicotinamide 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

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Preparation Products

2-Chloro-5-fluoronicotinonitrile Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8828	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-17392587031	1059@dideu.com	China	9996	58
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9539	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52704	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Changzhou Ansciep Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Finetech Industry Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 2-Chloro-5-fluoronicotinonitrile manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-25	2-Chloro-5-fluoronicotinonitrile 791644-48-9		1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
	2025-06-25	2-Chloro-5-fluoronicotinonitrile 791644-48-9	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd

2-Chloro-5-fluoronicotinonitrile
791644-48-9
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-5-fluoronicotinonitrile
791644-48-9
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2-Chloro-5-fluoronicotinonitrile Spectrum

2-Chloro-5-fluoronicotinonitrile(791644-48-9)¹HNMR

791644-48-9(2-Chloro-5-fluoronicotinonitrile)Related Search:

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5-Bromo-2-chloro-3-fluoropyridine 2-Chloro-5-fluoro-3-methylpyridine 2-Chloro-3-nitro-6-methylpyridine 2-Chloro-3-methyl-5-bromopyridine 2-Chloro-3-methyl-5-nitropyridine

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2-Chloro-3-pyridinamine 3-AMINO-2-CHLORO-5-PICOLINE 3-Amino-5-bromo-2-chloropyridine

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2-Chloro-5-fluoro-3-pyridinecarbonitrile 2-Chloro-5-fluoronicotinonitrile 3-Pyridinecarbonitrile, 2-chloro-5-fluoro- 2-Chloro-5-fluoronicotinonitrile ISO 9001：2015 REACH 2-Chloro-5-fluoropyridine-3-carbonitrile 791644-48-9

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