DIHYDROMETHYSTICIN
- CAS No.
- 19902-91-1
- Chemical Name:
- DIHYDROMETHYSTICIN
- Synonyms
- dhm;Nsc112159;PseudoMethysticin;DIHYDROMETHYSTICIN;DIHYDROMETHYLSTICIN;Dihydromethysticin-RM;7,8-dihydromethysticin;7,8-DIHYDROMETHYLSTICIN;Dihydromethysticin (CRM);Methysticin, 7,8-dihydro-
- CBNumber:
- CB3307966
- Molecular Formula:
- C15H16O5
- Molecular Weight:
- 276.28
- MDL Number:
- MFCD00221731
- MOL File:
- 19902-91-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (+)-Dihydromethysticin analytical standard | 52007 | 5mg | $539 |
| Dihydromethysticin ≥98% | 33880 | 1mg | $95 |
| Dihydromethysticin (CRM) | 41212 | 1mg | $161 |
| Dihydromethysticin ≥98% | 33880 | 5mg | $378 |
| Dihydromethysticin ≥98% | 27644 | 5mg | $197 |
| More product size | |||
| storage temp. | 2-8°C |
|---|---|
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| Boiling point | 476.1±45.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting point | 117-118 °C |
| form | Solid |
| color | White to Off-White |
| BRN | 91699 |
| Stability | Hygroscopic |
| Major Application | food and beverages |
| InChI | InChI=1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1 |
| InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N |
| SMILES | C1(=O)O[C@@H](CCC2=CC=C3OCOC3=C2)CC(OC)=C1 |
| LogP | 1.810 (est) |
| FDA UNII | FZ66MQ73GS |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
DIHYDROMETHYSTICIN price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 52007 | (+)-Dihydromethysticin analytical standard | 19902-91-1 | 5mg | $539 | 2022-05-15 | Buy |
| Cayman Chemical | 33880 | Dihydromethysticin ≥98% | 19902-91-1 | 1mg | $95 | 2026-04-30 | Buy |
| Cayman Chemical | 41212 | Dihydromethysticin (CRM) | 19902-91-1 | 1mg | $161 | 2026-04-30 | Buy |
| Cayman Chemical | 33880 | Dihydromethysticin ≥98% | 19902-91-1 | 5mg | $378 | 2026-04-30 | Buy |
| Cayman Chemical | 27644 | Dihydromethysticin ≥98% | 19902-91-1 | 5mg | $197 | 2026-04-30 | Buy |
DIHYDROMETHYSTICIN Chemical Properties,Uses,Production
Description
Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Pipermethysticum Forst.
Uses
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant.
Definition
ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether.
IC 50
CYP3
References
[1] D. D. JAMIESON P. H D. THE ANTINOCICEPTIVE ACTIONS OF KAVA COMPONENTS IN MICE[J]. Clinical and Experimental Pharmacology and Physiology, 1990, 17 7: 495-507. DOI: 10.1111/j.1440-1681.1990.tb01349.x
[2] CORD BACKHAUΒ Josef K. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents[J]. European journal of pharmacology, 1992, 215 2: Pages 265-269. DOI: 10.1016/0014-2999(92)90037-5
[3] JOHANNA WEISS. Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.[J]. Drug Metabolism and Disposition, 2005, 33 11: 1580-1583. DOI: 10.1124/dmd.105.005892
DIHYDROMETHYSTICIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213306 +8618374838656 | info@staherb.cn | China | 987 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from DIHYDROMETHYSTICIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-25 | DHM; DIHYDROMETHYSTICIN
19902-91-1
|
20MG | >95% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-07-17 | Dihydromethysticin
19902-91-1
|
$64.00-228.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | DIHYDROMETHYSTICIN
19902-91-1
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- DHM; DIHYDROMETHYSTICIN
19902-91-1
- $0.00
- >95% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Dihydromethysticin
19902-91-1
- $64.00-228.00
- 99.88%
- TargetMol Chemicals Inc.
-
- DIHYDROMETHYSTICIN
19902-91-1
- $9.80
- ≥98%
- Career Henan Chemical Co
