2,3,5,6-Tetrafluoropyridine
- CAS No.
- 2875-18-5
- Chemical Name:
- 2,3,5,6-Tetrafluoropyridine
- Synonyms
- 2,3,5,6-TetrafL;2,3,5,6-TETRAFLUOROPYRIDINE;Pyridine,2,3,5,6-tetrafluoro-;2,3,5,6-Tetrafluoropyridine98%;2,3,5,6-Tetrafluoropyridine,99%;2,3,5,6-Tetrafluoropyridine 98%;N-TERT-BUTYL-ALPHA-(4-NITROPHENYL)- &;2,3,5,6-Tetrafluoropyridine ISO 9001：2015 REACH
- CBNumber:
- CB3444784
- Molecular Formula:
- C5HF4N
- Molecular Weight:
- 151.06
- MDL Number:
- MFCD00011734
- MOL File:
- 2875-18-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2,3,5,6-Tetrafluoropyridine 95% | 316679 | 1g | $65.2 |
| 2,3,5,6-Tetrafluoropyridine >98.0%(GC) | T1778 | 1g | $25 |
| 2,3,5,6-Tetrafluoropyridine >98.0%(GC) | T1778 | 5g | $78 |
| 2,3,5,6-Tetrafluoropyridine 98% | PC9064 | 5g | $36 |
| 2,3,5,6-Tetrafluoropyridine 98% | PC9064 | 10g | $62 |
| More product size | |||
| Boiling point | 102 °C (lit.) |
|---|---|
| Density | 1.499 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 87 °F |
| storage temp. | Inert atmosphere,2-8°C |
| pka | -10.94±0.20(Predicted) |
| form | clear liquid |
| color | Colorless to Light yellow |
| Specific Gravity | 1.52 |
| InChI | InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H |
| InChIKey | HWIPMBCMGVXOKN-UHFFFAOYSA-N |
| SMILES | C1(F)=NC(F)=C(F)C=C1F |
| CAS DataBase Reference | 2875-18-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 2,3,5,6-tetrafluoro-(2875-18-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi,F,C | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 28-36 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Flammable/Irritant | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,3,5,6-Tetrafluoropyridine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 316679 | 2,3,5,6-Tetrafluoropyridine 95% | 2875-18-5 | 1g | $65.2 | 2023-06-20 | Buy |
| TCI Chemical | T1778 | 2,3,5,6-Tetrafluoropyridine >98.0%(GC) | 2875-18-5 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | T1778 | 2,3,5,6-Tetrafluoropyridine >98.0%(GC) | 2875-18-5 | 5g | $78 | 2026-04-30 | Buy |
| Apolloscientific | PC9064 | 2,3,5,6-Tetrafluoropyridine 98% | 2875-18-5 | 5g | $36 | 2026-06-04 | Buy |
| Apolloscientific | PC9064 | 2,3,5,6-Tetrafluoropyridine 98% | 2875-18-5 | 10g | $62 | 2026-06-04 | Buy |
2,3,5,6-Tetrafluoropyridine Chemical Properties,Uses,Production
Synthesis
Catalytic reduction of aryl chlorides, bromides and iodides is well documented,
however, aryl fluorides do not readily react under these conditions, owing to the strong
C-F bond and the high activation barrier to bond breaking. Work in our laboratories showed that at high temperatures, pentafluoropyridine was converted to 2,3,5,6-
tetrafluoropyridine using a palladium catalyst.
Preparation
An autoclave sprayed with PTFE was charged with pentafluoropyridine (20.0 g, 118 mmol), HBr (32.0 g, 400 mmol) and sulpholane (40 cm3) and heated at 200 ℃ for 48 h. The mixture was added to water and extracted into ether. The ether solution was shown to contain pentafluoropyridine (79%) and 2,3,5,6-tetrafluoropyridine (21%) by comparison of their GCMS and fluorine nmr spectra with authentic samples.
Description
Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medicine, pesticides, rubber, dyes and other fields. Since the 1960s, there have been hundreds of medicines, pesticides, dyes, and some special reagents developed with fluorine-containing aromatic compounds as intermediates. In the weakly basic pyridine ring, the nitrogen atom is more negatively charged, and then a fluorine atom with a strong electronegativity is introduced to synthesize a fluorine-containing pyridine intermediate.
Application
2,3,5,6-Tetrafluoropyridine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in organic synthesis processes and chemical and pharmaceutical synthesis processes in laboratory research and development.
Chemical Properties
clear colorless liquid
Uses
2,3,5,6-Tetrafluoropyridine is a fluoropyridine compound. The four fluorine atoms on its pyridine ring structure can be used for substitution reactions or as a fluorine source for preparing products such as battery materials.
2,3,5,6-Tetrafluoropyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Dongfan Chem. Co., Ltd. | 021-34500607 13391355195 | sales@dfanchem.com | CHINA | 61 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Klong Industrial Co., Ltd | 0086-519-68231162 | info@klongchem.com | CHINA | 131 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
Related articles
- Synthesis and Application of Tetrafluoropyridine
- Pyridine and its derivatives have been developed and utilized relatively early at home and abroad. It is widely used in medici....
- Dec 9，2019
View Lastest Price from 2,3,5,6-Tetrafluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-09 | 2,3,5,6-Tetrafluoropyridine
2875-18-5
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-06-25 | 2,3,5,6-Tetrafluoropyridine
2875-18-5
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 2,3,5,6-Tetrafluoropyridine
2875-18-5
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2,3,5,6-Tetrafluoropyridine
2875-18-5
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,3,5,6-Tetrafluoropyridine
2875-18-5
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,3,5,6-Tetrafluoropyridine
2875-18-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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