187-1, N-WASP INHIBITOR
- CAS No.
- 380488-27-7
- Chemical Name:
- 187-1, N-WASP INHIBITOR
- Synonyms
- CYCLO(LKDFDPDFLFDPLQ)2;N-WASP-INHIBITOR, 187-1;187-1, N-WASP INHIBITOR;M.W. 1784.13 C96H122N18O16;Cyclo(L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl-L-glutaminyl-L-lysyl-D-phenylalanyl-D-prolyl-D-phenylalanyl-L-phenylalanyl-D-prolyl)
- CBNumber:
- CB3676109
- Molecular Formula:
- C96H122N18O16
- Molecular Weight:
- 1784.11
- MDL Number:
- MFCD04974218
- MOL File:
- 380488-27-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-WASP-Inhibitor, 187-1 The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications. | 681660-M | 1 mg | $405 |
| N-WASP-Inhibitor, 187-1 The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications. | 681660-M | 1 unit | $377 |
| 187-1, N-WASP inhibitor ~99%(HPLC) | 254349 | 1mg | $522 |
| 187-1, N-WASP inhibitor | FQA48827 | 5mg | $1583.55 |
| 187-1, N-WASP inhibitor | FQA48827 | 10mg | $2533.7 |
| storage temp. | -20°C |
|---|---|
| solubility |
DMSO: 1mg/mL acetic acid: 5% |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble to 2 mg/ml in water |
| Sequence | Cyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}] |
| UNSPSC Code | 12352200 |
187-1, N-WASP INHIBITOR price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 681660-M | N-WASP-Inhibitor, 187-1 The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications. | 1 mg | $405 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 681660-M | N-WASP-Inhibitor, 187-1 The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications. | 1 unit | $377 | 2025-07-31 | Buy | |
| Usbiological | 254349 | 187-1, N-WASP inhibitor ~99%(HPLC) | 380488-27-7 | 1mg | $522 | 2026-06-03 | Buy |
| Biosynth | FQA48827 | 187-1, N-WASP inhibitor | 380488-27-7 | 5mg | $1583.55 | 2026-06-04 | Buy |
| Biosynth | FQA48827 | 187-1, N-WASP inhibitor | 380488-27-7 | 10mg | $2533.7 | 2026-06-04 | Buy |
187-1, N-WASP INHIBITOR Chemical Properties,Uses,Production
Uses
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein[1][2].
Biological Activity
Primary Target
Neural Wiskott Aldrich syndrome protein (N-WASP)', 'Target IC50: ~ 2 μM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract
References
[1] Peterson, et al. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. DOI:10.1073/pnas.201393198
[2] S Suetsugu, et al. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J DOI:10.1074/jbc.M102866200
187-1, N-WASP INHIBITOR Preparation Products And Raw materials
Raw materials
Preparation Products
187-1, N-WASP INHIBITOR Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7617 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7189 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | hanfangpharma@126.com; 18616537568 | hanfangpharma@126.com | China | 25801 | 58 |
