Carbenoxolone disodium
- CAS No.
- 7421-40-1
- Chemical Name:
- Carbenoxolone disodium
- Synonyms
- CARBENOXOLONE SODIUM;neogel;sanodin;duogastrone;pyrogastrone;20-beta)-3-bet;ulcus-tablinen;sodiumcarbenoxolone;Carbenoxalone Sodium;Carbenoxolone disodi
- CBNumber:
- CB3680281
- Molecular Formula:
- C34H48Na2O7
- Molecular Weight:
- 614.72
- MDL Number:
- MFCD03840711
- MOL File:
- 7421-40-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Carbenoxolone disodium salt ≥98% | C4790 | 1g | $59.6 |
| Carbenoxolone disodium salt ≥98% | C4790 | 5g | $248 |
| Carbenoxolone (sodium salt) ≥98% | 18240 | 1g | $42 |
| Carbenoxolone (sodium salt) ≥98% | 18240 | 5g | $174 |
| Carbenoxolone (sodium salt) ≥98% | 18240 | 10g | $307 |
| Melting point | >275°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | pKa1 4.18; pKa2 5.52(at 25℃) |
| color | White to Off-White |
| Water Solubility | Soluble in water to 100 mM. |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions |
SURFACTANT - CLEANSING SKIN CONDITIONING SURFACTANT - FOAM BOOSTING |
| InChIKey | BQENDLAVTKRQMS-FDPMUVMVSA-L |
| SMILES | [Na].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)[C@]4([H])[C@@]5(C)CC[C@H](OC(=O)CCC(O)=O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O |
| LogP | 7.083 (est) |
| CAS DataBase Reference | 7421-40-1(CAS DataBase Reference) |
| FDA UNII | F1MP7242Z5 |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RK0250000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Toxicity | LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan) | |||||||||
| NFPA 704 |
|
Carbenoxolone disodium price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C4790 | Carbenoxolone disodium salt ≥98% | 7421-40-1 | 1g | $59.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | C4790 | Carbenoxolone disodium salt ≥98% | 7421-40-1 | 5g | $248 | 2026-04-30 | Buy |
| Cayman Chemical | 18240 | Carbenoxolone (sodium salt) ≥98% | 7421-40-1 | 1g | $42 | 2026-04-30 | Buy |
| Cayman Chemical | 18240 | Carbenoxolone (sodium salt) ≥98% | 7421-40-1 | 5g | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 18240 | Carbenoxolone (sodium salt) ≥98% | 7421-40-1 | 10g | $307 | 2026-04-30 | Buy |
Carbenoxolone disodium Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Biogastrone,Winthrop,UK,1963
Uses
Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative
Uses
beta-adrenergic agonist, growth stimulant
Uses
Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
Definition
ChEBI: Carbenoxolone sodium is a triterpenoid.
Manufacturing Process
23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution
of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by
30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry
pyridine. The solution was heated on a boiling water bath for ten hours and
then poured into excess of dilute hydrochloric acid and ice. The fine gray
precipitate formed was filtered off, washed with water, dissolved in chloroform,
and the solution repeatedly extracted with dilute hydrochloric acid and later
with water. It was dried over sodium sulfate and evaporated to dryness.
Crystallization from methanol, using charcoal to effect decolorization, gave the
hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with
previous softening.
One molecular proportion of glycyrrhetinic acid hydrogen succinate was
ground with a dilute (5%) aqueous solution containing two molecular
proportions of sodium hydroxide. The solution was filtered and evaporated in
vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a
creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from
licorice root.
Therapeutic Function
Antiinflammatory (gastric)
General Description
Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.
Biological Activity
Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.
storage
Store at +4°C
References
[1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
[2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.
Carbenoxolone disodium Preparation Products And Raw materials
Carbenoxolone disodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3969 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9612 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24597 | 58 |
View Lastest Price from Carbenoxolone disodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Carbenoxolone disodium
7421-40-1
|
$30.00-97.00 | 99.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Carbenoxolone disodium
7421-40-1
|
$30.00-97.00 | 99.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Carbenoxolone disodium
7421-40-1
|
$30.00-97.00 | 99.69% | 10g | TargetMol Chemicals Inc. |
-
- Carbenoxolone disodium
7421-40-1
- $30.00-97.00
- 99.69%
- TargetMol Chemicals Inc.
-
- Carbenoxolone disodium
7421-40-1
- $30.00-97.00
- 99.69%
- TargetMol Chemicals Inc.
-
- Carbenoxolone disodium
7421-40-1
- $30.00-97.00
- 99.69%
- TargetMol Chemicals Inc.
