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ChemicalBook >> CAS DataBase List >>SUBSTANCE P

SUBSTANCE P

CAS No.
33507-63-0
Chemical Name:
SUBSTANCE P
Synonyms
Sub;TYR8;RPKPQFFGLM;Aids114081;SUBSTANCE P;P substance;Aids-114081;SUBSTANCE P;SUBSTANCE P;SUBSTANCE P
CBNumber:
CB4114260
Molecular Formula:
C63H98N18O13S
Molecular Weight:
1347.63
MDL Number:
MFCD00076780
MOL File:
33507-63-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-22 15:57:46
Product description Number Pack Size Price
Substance P - CAS 33507-63-0 - Calbiochem Neuropeptidefoundinhighconcentrationsinthegut. 05-23-0600 1mg $76
Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 05-23-0600 5MG $229
Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 05-23-0600 25MG $617
Substance P PurifiedbyProteinAandpeptideaffinitychromatography. 550039 200ul $694
Substance P Purifiedbyimmunoaffinitychromatography. 528725 100ul $736
More product size

SUBSTANCE P Properties

Melting point 148 °C
Density 1.42±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility H2O: 1 mg/mL
pka 13.26±0.46(Predicted)
form powder
color white
Water Solubility Soluble in water, DMSO, and Acetic Acid.
Sequence H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Cosmetics Ingredients Functions SKIN CONDITIONING - EMOLLIENT
SKIN PROTECTING
InChIKey ADNPLDHMAVUMIW-UHFFFAOYSA-N
FDA UNII 675VGV5J1D
UNSPSC Code 12352202
NACRES NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H312-H332-H302
Precautionary statements  P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
WGK Germany  3
F  3-10-21
Storage Class 11 - Combustible Solids

SUBSTANCE P price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptidefoundinhighconcentrationsinthegut. 33507-63-0 1mg $76 2026-04-30 Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 33507-63-0 5MG $229 2026-04-30 Buy
Sigma-Aldrich 05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem Neuropeptide found in high concentrations in the gut. 33507-63-0 25MG $617 2026-04-30 Buy
Usbiological 550039 Substance P PurifiedbyProteinAandpeptideaffinitychromatography. 200ul $694 2026-06-03 Buy
Usbiological 528725 Substance P Purifiedbyimmunoaffinitychromatography. 100ul $736 2026-06-03 Buy
Product number Packaging Price Buy
05-23-0600 1mg $76 Buy
05-23-0600 5MG $229 Buy
05-23-0600 25MG $617 Buy
550039 200ul $694 Buy
528725 100ul $736 Buy

SUBSTANCE P Chemical Properties,Uses,Production

Chemical Properties

White freeze-dried powder, soluble in water, high purity aqueous solution is very easy to inactivate, adding tween 80, gelatin, human plasma albumin or bovine gammaglobulin can increase its stability; pH greater than 8 is not stable, inactivated by pepsin and pancreatic curdling protease; it is advisable to be stored in a low pH, and filled with nitrogen or add antioxidants to avoid its inactivation.

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

General Description

Substance P is a polypeptide consisting of 11 amino acidresidues. It has been implicated in the transmission of“painful” sensory information through the spinal cord tohigher centers in the central nervous system. Substance Pis localized in the primary afferent sensory fibers. Other pharmacologicaleffects are vasodilatation, stimulation of smoothmuscles, stimulation of salivary secretion, and diuresis. In addition,this neuropeptide contributes to some inflammatory responses.Approximately 50% of the known neuropeptides aresynthesized as biologically inactive glycine extended precursorsthat require a carboxy-terminal posttranslational amidationfor biological activity. Amidation enzymes are responsiblefor the conversion of the carboxyl group of the neuropeptide tothe corresponding amide group and include the two amidatingenzymes peptidylglycine α-monooxygenase (PAM) and peptidylamidoglycolatelyase (PGL), which work sequentially toproduce the inflammatory neuropeptide Substance P from aninactive precursor peptide. Much research is being performedto exploit this mechanism of inflammation.

Biological Activity

Cell permeable: no', 'Primary Target
Substance P receptors', 'Product does not compete with ATP.', 'Reversible: no

storage

-20°C

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 225)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Getian Industrial Co., LTD 		+86-15373193816 mike@ge-tian.com China 268 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 995 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9389 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10378 58
Chengdu Youngshe Chemical Co., Ltd. 		+86-18108235634 Cecilia@youngshechem.com China 2345 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58

View Lastest Price from SUBSTANCE P manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Substance P acetate pictures 2026-07-21 Substance P acetate
$48.00-197.00 98.81% 10g TargetMol Chemicals Inc.
SUBSTANCE P pictures 2026-07-02 SUBSTANCE P
33507-63-0
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
SUBSTANCE P pictures 2025-04-04 SUBSTANCE P
33507-63-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • SUBSTANCE P pictures
  • SUBSTANCE P
    33507-63-0
  • $2.00-5.00
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • SUBSTANCE P pictures
  • SUBSTANCE P
    33507-63-0
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

SUBSTANCE P Spectrum

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 SUBSTANCE P, F & D VERSION OF S6883*ACET ATE (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE) SUBSTANCE P BOVINE SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] SUBSTANCE P (TYR8) SUBSTANCE P SUBSTANCE P AMIDE RPKPQFFGLM RPKPQQFFGLM-NH2 substance P (SP) L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-Met-NH2 L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 Neurokinin P P substance Aids114081 Aids-114081 (S)-N1-((5S,8S,14S,17S,20S)-23-aMino-14,17-dibenzyl-5-carbaMoyl-8-isobutyl-7,10,13,16,19,23-hexaoxo-2-thia-6,9,12,15,18-pentaazatricosan-20-yl)-2-((S)-1-((S)-6-aMino-2-((S)-1-((S)-2-aMino-5-guanidinopentanoyl)pyrrolidine-2-carboxaMido)hexanoyl)pyrrolidine H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt Substance P TFA salt Substance P Acetate Substance P,Neurokinin P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2,RPKPQQFFGLM-NH2?, >98% TYR8 SUBSTANCE P USP/EP/BP Substance P，Neurokinin P，Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2，RPKPQQFFGLM-NH2 Substance P (9CI, ACI) NK receptor,Neurokinin Receptor,Endogenous Metabolite,Substance P,inhibit,Tachykinin receptor,Inhibitor 33507-63-0free/12769-48-1 P substance amide, Neurokinin P Amide sh-Oligopeptide-73 (S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide Substance P, Sensory neuropeptide Substance P, 10 mM in DMSO SUBSTANCE P SUBSTANCE P SUBSTANCE P 2-[[2-[[2-[[2-[[2-[[5-Amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]am ino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpr Neurokinin P Amide、Substance P Sub 33507-63-0 C63H98N18O13S C63H98N18O13S1 Tachykinins Peptides Biochemicals and Reagents BioChemical Agonist Amino Acids and Peptides Peptide Tachykinin receptor TPI Peptide Receptors
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