4-Trifluoromethoxyphenylboronic acid
- CAS No.
- 139301-27-2
- Chemical Name:
- 4-Trifluoromethoxyphenylboronic acid
- Synonyms
- 4-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;AKOS BRN-0136;RARECHEM AH PB 0078;4-trifluoromethoxyborate;P-TRIFLUOROMETHOXY BENZOBORIC ACID;4-Trifluoromethoxyphenylboronic aci;4-(Trifluormethoxy)phenylboronic acid;4-(Trifluoromethoxy)phenylboronic aicd;P-(TRIFLUOROMETHOXY)PHENYLBORONIC ACID;4-(TRIFLUOROMETHOXY)PJHENYLBORONICACID
- CBNumber:
- CB4276832
- Molecular Formula:
- C7H6BF3O3
- Molecular Weight:
- 205.93
- MDL Number:
- MFCD01074648
- MOL File:
- 139301-27-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-(Trifluoromethoxy)phenylboronic acid ≥95% | 510130 | 5g | $222 |
| 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | T1773 | 5g | $37 |
| 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | T1773 | 25g | $142 |
| 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | FT61887 | 50g | $900 |
| 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | FT61887 | 500g | $900 |
| More product size | |||
| Melting point | 123-127 °C(lit.) |
|---|---|
| Boiling point | 256.6±50.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 8.29±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to beige |
| BRN | 8548201 |
| InChI | InChI=1S/C7H6BF3O3/c9-7(10,11)14-6-3-1-5(2-4-6)8(12)13/h1-4,12-13H |
| InChIKey | HUOFUOCSQCYFPW-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(OC(F)(F)F)C=C1)(O)O |
| CAS DataBase Reference | 139301-27-2(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Trifluoromethoxyphenylboronic acid price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 510130 | 4-(Trifluoromethoxy)phenylboronic acid ≥95% | 139301-27-2 | 5g | $222 | 2023-01-07 | Buy |
| TCI Chemical | T1773 | 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | 139301-27-2 | 5g | $37 | 2026-04-30 | Buy |
| TCI Chemical | T1773 | 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | 139301-27-2 | 25g | $142 | 2026-04-30 | Buy |
| Biosynth | FT61887 | 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | 139301-27-2 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FT61887 | 4-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | 139301-27-2 | 500g | $900 | 2026-06-04 | Buy |
4-Trifluoromethoxyphenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
white to beige crystalline powder
Uses
B-[4-(Trifluoromethoxy)phenyl]boronic Acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors used against DNA dependant protein kinases.
Application
4-Trifluoromethoxyphenylboronic acid can reactant involved in the synthesis of biologically active molecules including:
Lactate dehydrogenase inhibitors for use against cancer cell proliferation
Nitro-phenoxybenzoic acid derivatives for PAI-1 inhibition
PA-824 analogs for use as antituberculosis drugs
Modulators of survival motor neuron protein
Reactant involved in addition reactions and cross-coupling reactions including Suzuki-Miyaura cross-coupling
Synthesis
5419-55-6
407-14-7
139301-27-2
Example 1E Synthesis of 4-(trifluoromethoxy)phenylboronic acid: 1-bromo-4-(trifluoromethoxy)benzene (1.69 kg) and triisopropyl borate (1.46 kg) were dissolved in THF (6.75 L) at -70 °C. A hexane solution (3.27 L) of 2.25 M butyllithium was slowly added to this solution over a period of 2.3 hours, followed by stirring for 10 minutes. Next, the reaction was quenched with 6 M HCl (1.52 L) and stirred at room temperature for 18 hours. The reaction mixture was poured into a mixture of heptane (8.43 L) and 20% (w/w) aqueous sodium chloride solution (8.44 kg) and stirred for 10 min to separate the aqueous and organic phases. The organic phase was concentrated to give a white paste. The paste was dried in vacuum (100 mmHg) at ambient temperature while nitrogen was passed for 2 days. Subsequently, it was further dried at 40-50 °C for 18 h to give 1.306 kg (90.4% yield) of the target product 4-(trifluoromethoxy)phenylboronic acid as a solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 7.24-7.19 (m, 2H), 8.14-8.10 (m, 2H) and additional absorption peaks were observed at δ 7.19-7.15 (m, 2H) and 8.04-8.00 (m, 2H), which corresponded to the cyclic boronic acid trimer.
References
[1] Patent: US2002/19539, 2002, A1
4-Trifluoromethoxyphenylboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 670 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
View Lastest Price from 4-Trifluoromethoxyphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | 4-Trifluoromethoxyphenylboronic acid
139301-27-2
|
1kg | 99% | 100mt | Jinan Finer Chemical Co., Ltd | ||
 |
2026-07-09 | 4-Trifluoromethoxyphenylboronic acid
139301-27-2
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-18 | 4-Trifluoromethoxyphenylboronic acid
139301-27-2
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd |
-
- 4-Trifluoromethoxyphenylboronic acid
139301-27-2
- $0.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 4-Trifluoromethoxyphenylboronic acid
139301-27-2
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Trifluoromethoxyphenylboronic acid
139301-27-2
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
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