Fmoc-Val-Ala-OH
- CAS No.
- 150114-97-9
- Chemical Name:
- Fmoc-Val-Ala-OH
- Synonyms
- (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine;Fmoc-Val-Ala;(2S)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]propanoic acid;Fmoc-Val-Ala-OH;N-Fmoc-L-valyl-L-alanine;(9H-Fluoren-9-yl)MethOxy]Carbonyl Val-Ala-OH;N-[fluorenylmethoxycarbonyl]-L-valine-L-alanine;N-(9-fluorenylmethoxycarbonyl)-L-valyl-L-alanine;(((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl-L-alanine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine
- CBNumber:
- CB43054763
- Molecular Formula:
- C23H26N2O5
- Molecular Weight:
- 410.46
- MDL Number:
- MFCD28387722
- MOL File:
- 150114-97-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Fmoc-Val-Ala-OH 95% | bp-24076 | 10G | $120 |
| Fmoc-Val-Ala-OH 95% | bp-24076 | 25G | $220 |
| Fmoc-Val-Ala-OH 95% | bp-24076 | 50G | $430 |
| (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine 97% | F88310 | 250mg | $25 |
| (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine 97% | F88310 | 1g | $31 |
| Melting point | 217 - 219°C |
|---|---|
| Boiling point | 676.7±45.0 °C(Predicted) |
| Density | 1.236±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 3.47±0.10(Predicted) |
| color | White to Off-White |
| InChIKey | KQZMZNLKVKGMJS-XOBRGWDASA-N |
| SMILES | C(O)(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
Fmoc-Val-Ala-OH price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | bp-24076 | Fmoc-Val-Ala-OH 95% | 150114-97-9 | 10G | $120 | 2026-05-24 | Buy |
| BroadPharm | bp-24076 | Fmoc-Val-Ala-OH 95% | 150114-97-9 | 25G | $220 | 2026-05-24 | Buy |
| BroadPharm | bp-24076 | Fmoc-Val-Ala-OH 95% | 150114-97-9 | 50G | $430 | 2026-05-24 | Buy |
| Synthonix | F88310 | (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine 97% | 150114-97-9 | 250mg | $25 | 2026-05-06 | Buy |
| Synthonix | F88310 | (((9H-Fluoren-9-yl)methoxy)carbonyl)-L-valyl-L-alanine 97% | 150114-97-9 | 1g | $31 | 2026-05-06 | Buy |
Fmoc-Val-Ala-OH Chemical Properties,Uses,Production
Uses
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine is a reagent used in the synthesis of novel antibody-drug candidates in the improvement of current cancer treatment strategies.
Synthesis
1115-74-8
28920-43-6
150114-97-9
The general procedure for the synthesis of N-[Fmoc]-L-valyl-L-alanine from the compound (CAS:1115-74-8) and 9-fluorenylmethyl chloroformate is as follows: (a) (R)-2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoylpropionic acid (20a, 350 mg, 1.86 mmol) and Na2CO3 (493 mg, 4.65 mmol) were dissolved in distilled water (15 mL) and the mixture was cooled to 0 °C. Dioxane (15 mL) was then added (some precipitation appeared). A solution of Fmoc-Cl (504 mg, 1.95 mmol) in dioxane (15 mL) was added dropwise with vigorous stirring over 10 min. The resulting mixture was stirred at 0°C for 2 hours. After removing the ice bath, stirring was continued for 16 hours. The solvent was removed by rotary evaporation under reduced pressure and the residue was dissolved in water (150 mL). The pH was adjusted from 9 to 2 with aqueous 1N HCl. The aqueous layer was subsequently extracted with EtOAc (3 x 100 mL). The organic layers were combined, washed with brine (100 mL), dried with MgSO4, filtered and the volatiles were removed by rotary evaporation under reduced pressure to give pure HO-Ala-Val-Fmoc (20b, 746 mg, 97% yield). LC/MS analysis: 2.85 min (ES+) m/z (relative intensity) 410.60. 1H-NMR (400 MHz, CDCl3) δ 7.79 (d, J = 7.77 Hz, 2H), 7.60 (d, J = 7.77 Hz, 2H), 7.43 (d, J = 7.5 Hz, 2H), 7.34 (d, J = 7.5 Hz, 2H), 6.30 (bs, 1H), 5.30 (bs, 1H), 4.71- 7.56 (m, 1H), 4.54-4.36 (m, 2H), 4.08-3.91 (m, 1H), 2.21-2.07 (m, 1H), 1.50 (d, J = 1AHz, 3H), 1.06-0.90 (m, 6H).
References
[1] Patent: WO2014/57073, 2014, A1. Location in patent: Page/Page column 123; 124
[2] Patent: WO2014/57072, 2014, A1. Location in patent: Page/Page column 43
[3] Patent: WO2014/96365, 2014, A1. Location in patent: Page/Page column 200-201
[4] Patent: WO2014/130879, 2014, A2. Location in patent: Page/Page column 124; 125
[5] Patent: WO2015/52533, 2015, A1. Location in patent: Page/Page column 47; 48
Fmoc-Val-Ala-OH Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Fmoc-Val-Ala-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 15301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9942 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 | 1924344760@confluore.cn | China | 2997 | 58 |
View Lastest Price from Fmoc-Val-Ala-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Fmoc-Val-Ala-OH
150114-97-9
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-07 | Fmoc-Val-Ala-OH
150114-97-9
|
25g | >95.00% | 25g | Xian confluore Biological Technology Co., Ltd. |
-
- Fmoc-Val-Ala-OH
150114-97-9
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Fmoc-Val-Ala-OH
150114-97-9
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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