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Postion:Product Catalog >API>Specialty drugs>Dermatology drugs>Adapalene
Adapalene
  • Adapalene

Adapalene NEW

Price $40 $64 $129
Package 50mg 100mg 500mg
Supply Ability: 10g
Update Time: 2026-05-26

Product Details

Product Name: Adapalene CAS No.: 106685-40-9
Purity: 99.76% Supply Ability: 10g
Release date: 2026/05/26

Product Introduction

Bioactivity

NameAdapalene
DescriptionAdapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
In vitroIn rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes.
In vivoIn colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis.
StorageKeep away from direct sunlight,Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 2.51 mg/mL (6.08 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1 mg/mL (2.42 mM), Sonication is recommended.
Keywordstumor | RXR | RetinoidReceptor | Retinoid X receptors | Retinoid Receptor | retinoid | Retinoic acid receptors | RARγ | RARβ | RARα | RAR/RXR | RAR | Inhibitor | inhibit | GOT1 | CD-271 | CD 271 | Autophagy | Apoptosis | Adapalene | acne
Inhibitors RelatedStavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid
Related Compound LibrariesNuclear Receptor Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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