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ChemicalBook >> CAS DataBase List >>DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

CAS No.
1478-53-1
Chemical Name:
DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
Synonyms
DIETHYL (DIFLUOROMETHANE)PHOSPHONATE;diethyl(difluoromethyl)phosphonate;1-[difluoromethyl(ethoxy)phosphoryl]oxyethane;uoromethanephosphonate;Dimethyl(difluoromethyl)phosphonate;DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%;DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER;P-DifluoroMethylphosphonic Acid Diethyl Ester;Phosphonic acid,P-(difluoromethyl)-, diethyl ester;Difluoromethylphosphonicaciddiethylester , Diethyl Difluoromethanephosphonate
CBNumber:
CB4680440
Molecular Formula:
C5H11F2O3P
Molecular Weight:
188.11
MDL Number:
MFCD00192023
MOL File:
1478-53-1.mol
MSDS File:
SDS
Last updated:2026-05-28 01:16:07
Product description Number Pack Size Price
Diethyl (difluoromethyl)phosphonate 97% 751596 5g $71.9
Diethyl Difluoromethanephosphonate TRC-D444220-500MG 500mg $804
Diethyl Difluoromethanephosphonate TRC-D444220-200MG 200mg $370
Diethyl Difluoromethanephosphonate TRC-D444220-100MG 100mg $199
Diethyl Difluoromethanephosphonate 009460 1g $446
More product size

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Properties

Boiling point 96°C 15mm
Density 1.193
refractive index n20/D 1.388(lit.)
Flash point 113 °C
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Oil
Specific Gravity 1.193
color Clear Colourless
InChI InChI=1S/C5H11F2O3P/c1-3-9-11(8,5(6)7)10-4-2/h5H,3-4H2,1-2H3
InChIKey VVFGLBKYBBUTRO-UHFFFAOYSA-N
SMILES P(C(F)F)(=O)(OCC)OCC
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P261-P280
Hazard Codes  Xi
Risk Statements  34
Safety Statements  26-36/37/39
RIDADR  3265
WGK Germany  3
HazardClass  IRRITANT
HS Code  29319090
Storage Class 10 - Combustible liquids

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 751596 Diethyl (difluoromethyl)phosphonate 97% 1478-53-1 5g $71.9 2026-04-30 Buy
TRC TRC-D444220-500MG Diethyl Difluoromethanephosphonate 1478-53-1 500mg $804 2026-06-03 Buy
TRC TRC-D444220-200MG Diethyl Difluoromethanephosphonate 1478-53-1 200mg $370 2026-06-03 Buy
TRC TRC-D444220-100MG Diethyl Difluoromethanephosphonate 1478-53-1 100mg $199 2026-06-03 Buy
Usbiological 009460 Diethyl Difluoromethanephosphonate 1478-53-1 1g $446 2026-06-03 Buy
Product number Packaging Price Buy
751596 5g $71.9 Buy
TRC-D444220-500MG 500mg $804 Buy
TRC-D444220-200MG 200mg $370 Buy
TRC-D444220-100MG 100mg $199 Buy
009460 1g $446 Buy

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties,Uses,Production

Chemical Properties

Colourless Liquid

Uses

Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3

Synthesis

Diethyl Difluoromethylphosphonate is prepared by the reaction of sodium diethyl phosphite with Chlorodifluoromethane in hexane (49% yield) or in THF (77% yield) or generated in situ from diethyl bromodifluoromethylphosphonate and BuLi.

75-45-6
762-04-9
1478-53-1
Synthesis of DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER from Difluorochloromethane and Diethyl phosphite
Global( 110)Suppliers
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XINXIANG RUNYU MATERIAL CO., LTD.
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CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
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Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 17389186172 1077@dideu.com China 4001 58
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View Lastest Price from DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER pictures 2026-06-30 DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
1478-53-1
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Difluoromethylphosphonic acid diethyl ester pictures 2025-12-23 Difluoromethylphosphonic acid diethyl ester
1478-53-1
 1KG 98% 100 XINXIANG RUNYU MATERIAL CO., LTD.
Difluoromethylphosphonic acid diethyl ester pictures 2025-12-12 Difluoromethylphosphonic acid diethyl ester
1478-53-1
 $1.00 1KG 99% 20 tons Shaanxi Dideu Medichem Co. Ltd
DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96% P-DifluoroMethylphosphonic Acid Diethyl Ester Phosphonic acid,P-(difluoromethyl)-, diethyl ester uoromethanephosphonate diethyl(difluoromethyl)phosphonate Difluoromethylphosphonicaciddiethylester , Diethyl Difluoromethanephosphonate Dimethyl(difluoromethyl)phosphonate 1-[difluoromethyl(ethoxy)phosphoryl]oxyethane DIETHYL (DIFLUOROMETHANE)PHOSPHONATE 1478-53-1 C5H11F2O3P F2CHPOOC2H52 Inhibitors Intermediates Phosphorylating and Phosphitylating Agents
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