3-Bromo-2-hydroxypyridine
- CAS No.
- 13466-43-8
- Chemical Name:
- 3-Bromo-2-hydroxypyridine
- Synonyms
- 3-bromo-1,2-dihydropyridin-2-one;3-BROMO-2-PYRIDONE;3-BROMO-2-PYRIDINOL;IFLAB-BB F1371-0174;3-BROMO-PYRIDIN-2-OL;3-Bromo-2(1H)-pyridone;3-bromo pyridin-2H -one;3-BROMO-2(1H)-PYRIDINONE;3-bromo-1H-pyridin-2-one;2-hydro-3-bromo pyridine
- CBNumber:
- CB4747158
- Molecular Formula:
- C5H4BrNO
- Molecular Weight:
- 174
- MDL Number:
- MFCD03411569
- MOL File:
- 13466-43-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Bromo-2-hydroxypyridine 97% | 686387 | 1g | $124 |
| 3-Bromo-2-hydroxypyridine >97.0%(GC) | B2330 | 5g | $58 |
| 3-Bromo-2-hydroxypyridine >97.0%(GC) | B2330 | 25g | $201 |
| 3-Bromo-2-hydroxypyridine Asreported | 261813 | 1g | $297 |
| 3-Bromo-2-hydroxypyridine Asreported | 261813 | 2g | $409 |
| More product size | |||
| Melting point | 179-183 °C |
|---|---|
| Boiling point | 336.6±42.0 °C(Predicted) |
| Density | 1.776±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 10.53±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| Water Solubility | Slightly soluble in water. |
| BRN | 109846 |
| InChI | InChI=1S/C5H4BrNO/c6-4-2-1-3-7-5(4)8/h1-3H,(H,7,8) |
| InChIKey | YDUGVOUXNSWQSW-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC=C1Br |
| CAS DataBase Reference | 13466-43-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Bromo-2-hydroxypyridine price More Price(104)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 686387 | 3-Bromo-2-hydroxypyridine 97% | 13466-43-8 | 1g | $124 | 2023-06-20 | Buy |
| TCI Chemical | B2330 | 3-Bromo-2-hydroxypyridine >97.0%(GC) | 13466-43-8 | 5g | $58 | 2026-04-30 | Buy |
| TCI Chemical | B2330 | 3-Bromo-2-hydroxypyridine >97.0%(GC) | 13466-43-8 | 25g | $201 | 2026-04-30 | Buy |
| Usbiological | 261813 | 3-Bromo-2-hydroxypyridine Asreported | 13466-43-8 | 1g | $297 | 2026-06-03 | Buy |
| Usbiological | 261813 | 3-Bromo-2-hydroxypyridine Asreported | 13466-43-8 | 2g | $409 | 2026-06-03 | Buy |
3-Bromo-2-hydroxypyridine Chemical Properties,Uses,Production
Chemical Properties
Light yellow powder
Uses
3-Bromo-2-hydroxypyridine is sued as an active ingredient pharmaceuticals, in medicine.
Uses
3-Bromo-2-hydroxypyridine is used in the synthesis of pyrazolopyridines as γ-secratase modulators.
Synthesis
13534-99-1
13466-43-8
The general procedure for the synthesis of 3-bromo-2-hydroxypyridine from 2-amino-3-bromopyridine was as follows: sodium nitrite (24.2 g, 0.35 mol, 4.84 eq.) was dissolved in water (175 mL) at 0 °C and slowly added dropwise to a solution containing 2-amino-3-bromopyridine (12.5 g, 72.4 mmol) and sulfuric acid (35 mL, 0.66 mol , 9.10 eq.) in a solution of water (175 mL). The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, the reaction mixture was neutralized with sodium hydroxide solution to pH=7. The neutralized solution was extracted with chloroform (3 x 200 mL), the organic phases were combined and washed with brine (200 mL), dried over magnesium sulfate, filtered and concentrated in vacuum to afford the milky white solid product 3-bromo-2-hydroxypyridine (11.3 g, 90% yield). The product was characterized as follows: melting point 183 °C; IR (pure) νmax 3339, 3105, 2991, 2942, 1776, 1650, 1610, 1464 cm-1; 1H NMR (500 MHz, CDCl3) δ 7.87 (dd, J = 7.3, 1.9 Hz, 1H), 7.49 (dd, J = 6.4, 1.9 Hz, 1H), 6.24 (dd, J = 7.3, 6.4 Hz, 1H) ppm; 13C NMR (125 MHz, CDCl3) δ 161.9, 143.9, 134.4, 115.7, 107.7 ppm; HRMS (ESI) m/z [M + Na]+ Calculated value: 195.9369, measured value: 195.9373 (deviation +2.07 ppm).
References
[1] Organic Letters, 2016, vol. 18, # 13, p. 3106 - 3109
[2] Synthesis (Germany), 2016, vol. 48, # 20, p. 3575 - 3588
3-Bromo-2-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 3-Bromo-2-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 3-Bromo-2-hydroxypyridine
13466-43-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-09-02 | 3-Bromo-2-hydroxypyridine
13466-43-8
|
$1.00 | 1KG | 98% | 1kg; 10kg; 100kg | Career Henan Chemical Co |
-
- 3-Bromo-2-hydroxypyridine
13466-43-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Bromo-2-hydroxypyridine
13466-43-8
- $1.00
- 98%
- Career Henan Chemical Co
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