Pyrimidine-2-carboxylic acid
- CAS No.
- 31519-62-7
- Chemical Name:
- Pyrimidine-2-carboxylic acid
- Synonyms
- 2-PYRIMIDINECARBOXYLIC ACID;AvafilImpurity60;TIMTEC-BB SBB005602;RARECHEM AL BO 0759;2-CARBOXY-PYRIMIDINE;Avanafil Impurity 60;2-Pyrimidinecarboxylicaci;Pyrimidin-2-carboxylic acid;PYRIMIDINE-2-CARBOXYLIC ACID;2-Pyrimidinecarboxylic ac...
- CBNumber:
- CB4766450
- Molecular Formula:
- C5H4N2O2
- Molecular Weight:
- 124.1
- MDL Number:
- MFCD00856161
- MOL File:
- 31519-62-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pyrimidine-2-carboxylic acid 97% | 754315 | 1g | $57.4 |
| Pyrimidine-2-carboxylic Acid >98.0%(GC)(T) | P2328 | 1g | $81 |
| 2-carboxy-Pyrimidine ≥95% | 10007123 | 500mg | $29 |
| 2-carboxy-Pyrimidine ≥95% | 10007123 | 1g | $51 |
| 2-carboxy-Pyrimidine ≥95% | 10007123 | 500mg | $26 |
| More product size | |||
| Melting point | 182-185°C |
|---|---|
| Boiling point | 362.6±25.0 °C(Predicted) |
| Density | 1.403±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in ethanol, Dimethyl sulfoxide (DMSO), Dimethylformamide (DMF), and solution of Phosphate Buffered Saline (PBS). |
| pka | 3.08±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| λmax | 246nm(H2O (pH 7))(lit.) |
| InChI | 1S/C5H4N2O2/c8-5(9)4-6-2-1-3-7-4/h1-3H,(H,8,9) |
| InChIKey | ZFCHNZDUMIOWFV-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ncccn1 |
| CAS DataBase Reference | 31519-62-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
Pyrimidine-2-carboxylic acid price More Price(107)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 754315 | Pyrimidine-2-carboxylic acid 97% | 31519-62-7 | 1g | $57.4 | 2026-04-30 | Buy |
| TCI Chemical | P2328 | Pyrimidine-2-carboxylic Acid >98.0%(GC)(T) | 31519-62-7 | 1g | $81 | 2023-06-20 | Buy |
| Cayman Chemical | 10007123 | 2-carboxy-Pyrimidine ≥95% | 31519-62-7 | 500mg | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 10007123 | 2-carboxy-Pyrimidine ≥95% | 31519-62-7 | 1g | $51 | 2026-04-30 | Buy |
| Cayman Chemical | 10007123 | 2-carboxy-Pyrimidine ≥95% | 31519-62-7 | 500mg | $26 | 2024-03-01 | Buy |
Pyrimidine-2-carboxylic acid Chemical Properties,Uses,Production
Description
2-
Chemical Properties
White to off-white solid
Uses
2-carboxy-Pyrimidine is a synthetic intermediate.
Synthesis
14080-23-0
31519-62-7
Synthesis of pyrimidine-2-carboxylic acid (11): pyrimidine-2-carbonitrile (10) (201 mg, 1.914 mmol) was dissolved in water (5 mL) under stirring conditions, followed by addition of KOH (214.3 mg, 3.83 mmol). The reaction mixture was heated to reflux for 3 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of raw materials, the reaction mixture was slowly cooled to room temperature. The reaction mixture was neutralized with 2N HCl solution and subsequently the aqueous phase was removed by rotary evaporation to give the crude product. The crude product was extracted with ethyl acetate (EtOAc), the organic phases were combined and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to afford pyrimidine-2-carboxylic acid (11) (84 mg, 35.4% yield), which could be used in subsequent reactions without further purification.TLC conditions: 80% EtOAc/hexane (Rf: 0.05).1H NMR (400 MHz, CD3OD-d4): δ 8.83 (br s, 2H), 7.47 (t, J = 4.8 Hz, 1H).
References
[1] Dalton Transactions, 2011, vol. 40, # 20, p. 5476 - 5482
[2] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2676 - 2699
[3] Chemical Communications, 2016, vol. 52, # 54, p. 8459 - 8462
[4] Patent: WO2013/13238, 2013, A2. Location in patent: Page/Page column 49
[5] Patent: KR2015/128789, 2015, A. Location in patent: Paragraph 0818; 0820; 0821
Pyrimidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from Pyrimidine-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | Pyrimidine-2-carboxylic acid
31519-62-7
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2021-07-13 | 2-Pyrimidinecarboxylic acid
31519-62-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | 2-Pyrimidinecarboxylic acid
31519-62-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Pyrimidine-2-carboxylic acid
31519-62-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Pyrimidinecarboxylic acid
31519-62-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Pyrimidinecarboxylic acid
31519-62-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
