jolkinolide B
- CAS No.
- 37905-08-1
- Chemical Name:
- jolkinolide B
- Synonyms
- Ritacin-P;Ritacin P;jolkinolide B;Jolkinolide B, 10 mM in DMSO;2'',3'':3,4]phenanthro[3,2-b]furan-9(7aH)-one;(4aR,6aS,7aR,10aR,11aR,11bR,11cR)-4,4,8,11c-tetramethyl-1,2,...;1,4-dibutyl-N-(2,6-dimethylphenyl)piperazine-2-carboxamide,nitrous acid;(4aR,6aS,7aR,10aR,11aR,11bR,11cR)-4,4,8,11c-Tetramethyl-1,2,3,4,4a,5,6,11a,11b,11c-decahydrobis(oxireno)[2',3':1,10a;(4aR,6aS,7aβ,10aR)-1,2,3,4,4aα,5,6,11aβ,11bα,11c-Decahydro-4,4,8,11cβ-tetramethylbisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one;Bisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one, 1,2,3,4,4a,5,6,11a,11b,11c-decahydro-4,4,8,11c-tetramethyl-, (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-
- CBNumber:
- CB51306403
- Molecular Formula:
- C20H26O4
- Molecular Weight:
- 330.42
- MDL Number:
- MFCD28387432
- MOL File:
- 37905-08-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Jolkinolide B ≥95% (HPLC) | SML3615 | 5 mg | $87.4 |
| Jolkinolide B ≥95% (HPLC) | SML3615 | 25 mg | $352 |
| Jolkinolide B ≥98% | 300515 | 10mg | $468 |
| Jolkinolide B | MBA90508 | 5mg | $221.05 |
| Jolkinolide B | MBA90508 | 10mg | $375.9 |
| More product size | |||
| Melting point | 213-215℃ |
|---|---|
| Boiling point | 497.1±45.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | -10 to -25°C |
| solubility | DMSO: 2mg/mL, clear (Warmed) |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C20H26O4/c1-10-12-14-19(22-14)9-6-11-17(2,3)7-5-8-18(11,4)13(19)15-20(12,23-15)24-16(10)21/h11,13-15H,5-9H2,1-4H3/t11-,13+,14-,15-,18-,19+,20-/m1/s1 |
| InChIKey | SOVOCMGDFRGRKF-MCDHERAVSA-N |
| SMILES | O1[C@@]32OC(=O)C(=C3[C@H]4O[C@]54[C@@H]([C@H]21)[C@]6([C@@H](C(CCC6)(C)C)CC5)C)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
jolkinolide B price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3615 | Jolkinolide B ≥95% (HPLC) | 37905-08-1 | 5 mg | $87.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3615 | Jolkinolide B ≥95% (HPLC) | 37905-08-1 | 25 mg | $352 | 2026-04-30 | Buy |
| Usbiological | 300515 | Jolkinolide B ≥98% | 37905-08-1 | 10mg | $468 | 2026-06-03 | Buy |
| Biosynth | MBA90508 | Jolkinolide B | 37905-08-1 | 5mg | $221.05 | 2026-06-04 | Buy |
| Biosynth | MBA90508 | Jolkinolide B | 37905-08-1 | 10mg | $375.9 | 2026-06-04 | Buy |
jolkinolide B Chemical Properties,Uses,Production
Uses
Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells[1].
Definition
ChEBI: A natural product found in Euphorbia fischeriana.
Biological Activity
Jolkinolide B is a diterpenoid isolated from the dried root of Euphorbia fischeriana steud th at exhibits anticancer, anti-inflammatory and immunomodulatory activities. Jolkinolide B induces apoptosis in numerous human cancer cell lines including breast cancer MDA-MB-231, MCF7, chronic myeloid leukemia K562, leukemic U937 and LNCaP cells. Apparently, it induces apoptosis in mouse melanoma B16F10 cells through downregulation of mRNA expression.
References
[1] Wang, J., Zhou, Y., Bai, X. et al. Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells 32, 451–457 (2011). DOI:10.1007/s10059-011-0137-0
jolkinolide B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 4616 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8613588737631 | chem1022@hengdian-group.com | China | 1478 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
View Lastest Price from jolkinolide B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | jolkinolide B
37905-08-1
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-11 | Jolkinolide B
37905-08-1
|
$60.00-228.00 | 99.99% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Jolkinolide B
37905-08-1
|
20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- jolkinolide B
37905-08-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Jolkinolide B
37905-08-1
- $60.00-228.00
- 99.99%
- TargetMol Chemicals Inc.
-
- Jolkinolide B
37905-08-1
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
