3-isobutylglutaric acid
- CAS No.
- 75143-89-4
- Chemical Name:
- 3-isobutylglutaric acid
- Synonyms
- 3-Isobutylpentanedioic acid;Pregabalin IMpurity I;Pregabalin Diacid-Imp;3-Isobutylglutaricaci;Isobutyl Glutaric Acid;3-isobutylglutaric acid;Pregabalin Impurity B(EP);3-ISOBUTYLPENTANEDIOC ACID;Pregabalin Impurity (IBGA);3-Isobutylglutaric acid 99%
- CBNumber:
- CB51458214
- Molecular Formula:
- C9H16O4
- Molecular Weight:
- 188.22
- MDL Number:
- MFCD15529751
- MOL File:
- 75143-89-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 017343 | 10g | $418 |
| 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 017343 | 25g | $814 |
| 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 017343 | 100g | $1267 |
| 3-Isobutylglutaric acid 97% | OR51987 | 25g | $21 |
| 3-Isobutylglutaric acid 97% | OR51987 | 100g | $44 |
| More product size | |||
| Melting point | 47 °C |
|---|---|
| Boiling point | 326.2±15.0 °C(Predicted) |
| Density | 1.126±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 4.19±0.10(Predicted) |
| color | White to Pale Brown |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1S/C9H16O4/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H,10,11)(H,12,13) |
| InChIKey | UATSLDZQNXAKMA-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CC(CC(C)C)CC(O)=O |
| FDA UNII | EMH1IVR5QH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H361 |
| Precautionary statements | P310-P260-P280-P308+P313 |
| HS Code | 2917198090 |
3-isobutylglutaric acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 017343 | 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 75143-89-4 | 10g | $418 | 2026-06-03 | Buy |
| Usbiological | 017343 | 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 75143-89-4 | 25g | $814 | 2026-06-03 | Buy |
| Usbiological | 017343 | 3-(2-Methylpropyl)pentanedioic Acid ≥98%(HPLC) | 75143-89-4 | 100g | $1267 | 2026-06-03 | Buy |
| Apolloscientific | OR51987 | 3-Isobutylglutaric acid 97% | 75143-89-4 | 25g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR51987 | 3-Isobutylglutaric acid 97% | 75143-89-4 | 100g | $44 | 2026-06-04 | Buy |
3-isobutylglutaric acid Chemical Properties,Uses,Production
Chemical Properties
Pale Brown Solid
Uses
An impurity of Pregabalin (P704800) with anticonvulsant properties.
Application
3-Butylglutaric acid is an intermediate in the synthesis of pregabalin.Pregabalin is approved by the United States Food and Drug Administration (FDA) to treat neuropathic pain associated with diabetic peripheral neuropathy, spinal cord injury, and postherpetic neuralgia. Pregabalin is FDA-approved for the treatment of fibromyalgia. Pregabalin also has FDA approval as adjunctive therapy for partial-onset seizures in adults with epilepsy.
Synthesis
3-isobutylglutaric acid, a potential impurity which is base hydrolyzed product during Hofmann reaction, was synthesized by the reaction of (R)-(-)-3-carbamoylmethyl-5-methylhexanoic acid with excess of sodium hydroxide at elevated temperature[1].
References
[1] Sripathi, S., Somesetti, N. R., Veeramalla, R., Challa, N. R., Peddi, S., Karnati, V. R. (2010). Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin. Arkivoc, 2010 1. https://doi.org/10.3998/ARK.5550190.0011.A22
3-isobutylglutaric acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +86-15383190639 | admin@86-ss.com | China | 999 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 421 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 13734021967 | kaia@neputrading.com | China | 1001 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2430 | 58 |
View Lastest Price from 3-isobutylglutaric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-31 | 3-isobutylglutaric acid
75143-89-4
|
$800.00-990.00 | 1ton | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-06-30 | 3-isobutylglutaric acid
75143-89-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 3-Isobutylglutaric Acid
75143-89-4
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 3-isobutylglutaric acid
75143-89-4
- $800.00-990.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 3-isobutylglutaric acid
75143-89-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Isobutylglutaric Acid
75143-89-4
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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